共查询到20条相似文献,搜索用时 15 毫秒
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《Current opinion in microbiology》2002,5(5):461
A selection of World Wide Web sites relevant to papers published in this issue of Current Opinion in Microbiology. 相似文献
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Danielle Gerhard 《The Yale journal of biology and medicine》2013,86(2):284-285
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Cowley AW 《American journal of physiology. Regulatory, integrative and comparative physiology》2003,284(3):R611-R627
The Cannon lecture this year illustrates how knowledge of DNA sequences of complex living organisms is beginning to shape the landscape of physiology in the 21st century. Enormous challenges and opportunities now exist for physiologists to relate the galaxy of genes to normal and pathological functions. The first extensive genomic systems biology map for cardiovascular and renal function was completed last year as well as a new hypothesis-generating tool ("physiological profiling") that enables us to hypothesize relationships between specific genes responsible for the regulation of regulatory pathways. Techniques of chromosomal substitution (consomic and congenic rats) are beginning to confirm statistical results from linkage analysis studies, narrow the regions of genetic interest for positional cloning, and provide genetically well-defined control strains for physiological studies. Patterns of gene expression identified by microarray and mapping of expressed genes to chromosomal sites are adding to the understanding of systems physiology. The previously unimaginable goal of connecting approximately 36,000 genes to the complex functions of mammalian systems is indeed well underway. 相似文献
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Antoine Kremer Albert G. Abbott John E. Carlson Paul S. Manos Christophe Plomion Paul Sisco Margaret E. Staton Saneyoshi Ueno Giovanni G. Vendramin 《Tree Genetics & Genomes》2012,8(3):583-610
An overview of recent achievements and development of genomic resources in the Fagaceae is provided, with major emphasis on the genera Castanea and Quercus. The Fagaceae is a large plant family comprising more than 900 species belonging to 8?C10 genera. Using a wide range of molecular markers, population genetics and gene diversity surveys were the focus of many studies during the past 20?years. This work set the stage for investigations in genomics beginning in the early 1990s and facilitated the application of genetic and quantitative trait loci mapping approaches. Transferability of markers across species and comparative mapping have indicated tight macrosynteny between Quercus and Castanea. Omic technologies were more recently developed and the corresponding resources are accessible via electronic and physical repositories (expressed sequence tag sequences, single-nucleotide polymorphisms, candidate genes, cDNA clones, bacterial artificial chromosome (BAC) libraries) that have been installed in North America and Europe. BAC libraries and physical maps were also constructed in Castanea and Quercus and provide the necessary resources for full nuclear genome sequencing projects that are currently under way in Castanea mollissima (Chinese chestnut) and Quercus robur (pedunculate oak). 相似文献
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The use of biological weapons has been recorded throughout history. However, the anthrax-tainted letters of the fall of 2001 caused shock and panic in several countries. Knowledge of the principal bacteriological weapons allows design of novel rapid DNA-based diagnostic tests that should help defuse the impact of future bioterrorist attacks. Less than one-hour real-time PCR identification of bacteria and their associated antibiotic resistance genes will revolutionize the practice of medicine. 相似文献
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