共查询到20条相似文献,搜索用时 31 毫秒
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Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex 总被引:10,自引:0,他引:10
Willis DM Loewy AP Charlton-Kachigian N Shao JS Ornitz DM Towler DA 《The Journal of biological chemistry》2002,277(40):37280-37291
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Dlx3 transcriptional regulation of osteoblast differentiation: temporal recruitment of Msx2, Dlx3, and Dlx5 homeodomain proteins to chromatin of the osteocalcin gene 总被引:5,自引:0,他引:5
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Hassan MQ Javed A Morasso MI Karlin J Montecino M van Wijnen AJ Stein GS Stein JL Lian JB 《Molecular and cellular biology》2004,24(20):9248-9261
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Ectopic Msx2 overexpression inhibits and Msx2 antisense stimulates calvarial osteoblast differentiation. 总被引:4,自引:0,他引:4
M Dodig T Tadic M S Kronenberg S Dacic Y H Liu R Maxson D W Rowe A C Lichtler 《Developmental biology》1999,209(2):298-307
Msx2 is believed to play a role in regulating bone development, particularly in sutures of cranial bone. In this study we investigated the effects of retroviral-mediated overexpression of Msx2 mRNA, in both sense and antisense orientations, on primary cultured chick calvarial osteoblasts. Unregulated overexpression of sense mRNA produced high levels of Msx2 protein throughout the culture period, preventing the expected fall as the cells differentiate. The continued high expression of Msx2 prevented osteoblastic differentiation and mineralization of the extracellular matrix. In contrast, expression of antisense Msx2 RNA decreased proliferation and accelerated differentiation. In other studies, we showed that the Msx2 promoter was widely expressed during the proliferative phase of mouse calvarial osteoblast cultures but was preferentially downregulated in osteoblastic nodules. These results support a model in which Msx2 prevents differentiation and stimulates proliferation of cells at the extreme ends of the osteogenic fronts of the calvariae, facilitating expansion of the skull and closure of the suture. 相似文献
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Bone-specific transcription factor Runx2 interacts with the 1alpha,25-dihydroxyvitamin D3 receptor to up-regulate rat osteocalcin gene expression in osteoblastic cells 总被引:3,自引:0,他引:3
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Paredes R Arriagada G Cruzat F Villagra A Olate J Zaidi K van Wijnen A Lian JB Stein GS Stein JL Montecino M 《Molecular and cellular biology》2004,24(20):8847-8861
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Hodkinson PS Elliott PA Lad Y McHugh BJ MacKinnon AC Haslett C Sethi T 《The Journal of biological chemistry》2007,282(39):28991-29001