共查询到20条相似文献,搜索用时 31 毫秒
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Grégory Effantin Ryosuke Hamasaki Takeru Kawasaki Maria Bacia Christine Moriscot Winfried Weissenhorn Takashi Yamada Guy Schoehn 《Structure (London, England : 1993)》2013,21(2):298-305
Highlights? ?RSL1, a jumbo phage, is almost completely covered by decorating proteins ? The tail structure is reported to be 9 Å, revealing unprecedented structural details ? The tail inner tube shows structural similarities to the bacterial type VI secretion system ? The long fibers can stabilize phiRSL1 once it is bound to the host cell surface 相似文献
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Nina Simon Edwin Lasonder Matthias Scheuermayer Andrea Kuehn Sabrina Tews Rainer Fischer Peter F. Zipfel Christine Skerka Gabriele Pradel 《Cell host & microbe》2013,13(1):29-41
Highlights? Malaria gametes evade human complement by binding factor H ? The plasmodial protein PfGAP50 binds to factor H on the gamete surface ? Binding of factor H results in inactivation of the complement protein C3b ? Functional inhibition of factor H or PfGAP50 reduces parasite transmission to the mosquito 相似文献
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Marco Nardini Nerina Gnesutta Giacomo Donati Raffaella Gatta Claudia Forni Andrea Fossati Clemens Vonrhein Dino Moras Christophe Romier Martino Bolognesi Roberto Mantovani 《Cell》2013,152(1-2):132-143
Highlights? 3D structure of NF-Y/CCAAT shows close relationships to core histones H2A/H2B ? NF-YA displays a sequence-specific DNA minor groove-binding module ? Histone H2B and NF-YB share a functional posttranslational modification ? NF-Y binding and monoubiquitination are early events in gene activation 相似文献
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Jaehoon Kim Jung-Ae Kim Robert K. McGinty Uyen T.T. Nguyen Tom W. Muir C. David Allis Robert G. Roeder 《Molecular cell》2013,49(6):1121-1133
Highlights? H2B ubiquitylation directly stimulates H3K4 methylation by the yeast Set1 complex ? Swd2 is not directly required for the H3K4 methylation activity of the yeast Set1 complex ? The Set1 n-SET domain plays a critical role in H2Bub-dependent H3K4 methylation ? Spp1 is conditionally involved in n-SET- and H2Bub-dependent H3K4 methylation 相似文献
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Rui Fang Fei Chen Zhenghong Dong Di Hu Andrew J. Barbera Erin A. Clark Jian Fang Ying Yang Pinchao Mei Michael Rutenberg Ze Li Ying Zhang Youwei Xu Huirong Yang Ping Wang Matthew D. Simon Qiongjie Zhou Jing Li Yujiang Geno Shi 《Molecular cell》2013,49(3):558-570
Highlights? Identifying NPAC as a novel LSD2 cofactor stimulating H3K4 demethylation ? Structure determination of LSD2 alone or in complex with NPAC and histone H3 peptide ? Defining the key NPAC residues essential for its intrinsic LSD2 cofactor activity ? Establishing a molecular model for how a cofactor regulates histone demethylation 相似文献
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Vérane Sommermeyer Claire Béneut Emmanuel Chaplais Maria Elisabetta Serrentino Valérie Borde 《Molecular cell》2013,49(1):43-54
Highlights? Spp1 and histone H3K4 residue are important for meiotic DSB formation ? Spp1 physically interacts with the DSB protein Mer2 ? Spp1 in meiosis is not with RNA Pol II, but on chromosome axes in DSB-rich domains ? Spp1’s PHD finger tethers H3K4me3 regions to chromosome axes for DSB formation 相似文献
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Eva M. Huber Daniel H. Scharf Peter Hortschansky Michael Groll Axel A. Brakhage 《Structure (London, England : 1993)》2012,20(10):1757-1768
Highlights? CBC binds to the minor groove of the DNA and bends it in a nucleosome-like manner ? Interactions of subunit HapB with DNA explain the sequence specificity of the CBC ? Anchor A of HapB tethers the CBC to the CCAAT box by minor groove widening ? Interactions of the CBC with the histones H3/H4 of the nucleosome are modeled 相似文献
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《Molecular & cellular proteomics : MCP》2019,18(11):2262-2272
Highlights
- •18O/16O labeling N-glycopeptide quantification for 40-kDa band in HCC and LC.
- •MRM verification of aberrant N-glycopeptides in healthy-HBV-LC-HCC cascade.
- •TPLTAN205ITK (H5N5S1F1) and (H5N4S2F1) of IgA2 change in liver diseases.
- •Variation in two N-glycopeptides abundance not caused by protein concentration.
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Highlights? Two structural elements of histone H4 mRNA drive translation initiation ? Ribosome is tethered by an eIF4E-binding site located in the coding region ? A RNA three-way helix junction element positions ribosome on the start codon ? The m7G cap-binding pocket formed by the mRNA controls histone translation 相似文献
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《Current opinion in biotechnology》2013,24(3):369-375
Highlights► Comparing biofuel crops is exceedingly difficult using conventional measurement methods. ► The PETRO approach quantitatively compares biological matter in terms of energy and carbon. ► Tracking carbon flux from air to liquid fuel compares all biofuel crop yields on a common basis. ► Reporting energy yields (GJ ha−1 y−1) and carbon flux (MgC ha−1 y−1) enables regional comparison. 相似文献
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Zimanyi CM Ando N Brignole EJ Asturias FJ Stubbe J Drennan CL 《Structure (London, England : 1993)》2012,20(8):1374-1383
Highlights? Two structures of inactivated RNRs show two concatenated α4β4 rings in the crystal ? Solution scattering shows rings interlock in the presence of crystallization solution ? Electron microscopy shows open and incomplete states of ring formation ? Mechanism of protein ring concatenation by ring opening and closing is proposed 相似文献
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Li X Beeson WT Phillips CM Marletta MA Cate JH 《Structure (London, England : 1993)》2012,20(6):1051-1061
Highlights? 1.1/1.37 Å polysaccharide monooxygenases structures have active-site dioxygen species ? The structures reveal a large variance in substrate binding surfaces ? Proposed electron transport pathways in polysaccharide monooxygenases are conserved ? Polysaccharide monooxygenases and CBM33 enzymes likely bind substrates differently 相似文献
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Tamar Hermesh Bruno Moltedo Thomas M. Moran Carolina B. López 《Cell host & microbe》2010,7(5):343-353
Highlights? Lung-produced type I interferons instruct bone marrow cells during respiratory virus infections ? IFN-exposed bone marrow leukocytes become resistant to virus infection ? Primed and protected bone marrow leukocytes migrate to the infected lung and contribute to virus clearance 相似文献
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Highlights? ESCs with short telomeres do not stably differentiate and can resume proliferation ? Critically short telomeres impair Nanog regulation during ESC differentiation ? Short telomeres elicit genome-wide DNA hypomethylation and altered H3K27me3 levels ? Impaired DNA methylation and differentiation are rescued by Dnmt3b or telomere elongation 相似文献
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Sen GL Boxer LD Webster DE Bussat RT Qu K Zarnegar BJ Johnston D Siprashvili Z Khavari PA 《Developmental cell》2012,22(3):669-677
Highlights? Induction of ZNF750 expression is necessary for terminal epidermal differentiation ? The C2H2 domain of ZNF750 is necessary for its prodifferentiation function ? p63 is necessary for the induction of ZNF750 expression during differentiation ? ZNF750 activates the expression of KLF4 to drive differentiation gene expression 相似文献
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Rebecca A. Oot Li-Shar Huang Edward A. Berry Stephan Wilkens 《Structure (London, England : 1993)》2012,20(11):1881-1892
Highlights? Two conformations of yeast V-ATPase EGChead peripheral stalk complex were solved ? The EG heterodimer of the eukaryotic V-ATPase forms a noncanonical coiled coil ? Subunit G contains a conserved random coiled bulge that interrupts the coiled coil ? The EGChead interaction represents an important target for therapeutic development 相似文献