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Sharma MK Liu RZ Thisse C Thisse B Denovan-Wright EM Wright JM 《The FEBS journal》2006,273(14):3216-3229
Fatty acid-binding protein type 1 (FABP1), commonly termed liver-type fatty acid-binding protein (L-FABP), is encoded by a single gene in mammals. We cloned and sequenced cDNAs for two distinct FABP1s in zebrafish coded by genes designated fabp1a and fabp1b. The zebrafish proteins, FABP1a and FABP1b, show highest sequence identity and similarity to the human protein FABP1. Zebrafish fabp1a and fabp1b genes were assigned to linkage groups 5 and 8, respectively. Both linkage groups show conserved syntenies to a segment of mouse chromosome 6, rat chromosome 4 and human chromosome 2 harboring the FABP1 locus. Phylogenetic analysis further suggests that zebrafish fabp1a and fabp1b genes are orthologs of mammalian FABP1 and most likely arose by a whole-genome duplication event in the ray-finned fish lineage, estimated to have occurred 200-450 million years ago. The paralogous fabp10 gene encoding basic L-FABP, found to date in only nonmammalian vertebrates, was assigned to zebrafish linkage group 16. RT-PCR amplification of mRNA in adults, and in situ hybridization to whole-mount embryos to fabp1a, fabp1b and fapb10 mRNAs, revealed a distinct and differential pattern of expression for the fabp1a, fabp1b and fabp10 genes in zebrafish, suggesting a division of function for these orthogolous and paralogous gene products following their duplication in the vertebrate genome. The differential and complementary expression patterns of the zebrafish fabp1a, fapb1b and fabp10 genes imply a hierarchical subfunctionalization that may account for the retention of both the duplicated fabp1a and fabp1b genes, and the fabp10 gene in the zebrafish genome. 相似文献
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Comparison of the starch synthesis genes between maize and rice: copies, chromosome location and expression divergence 总被引:1,自引:0,他引:1
Hong-Bo Yan Xiao-Xue Pan Hua-Wu Jiang Guo-Jiang Wu 《TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik》2009,119(5):815-825
Gene duplication and divergence are important evolutionary processes. It has been suggested that a whole genome duplication
(WGD) event occurred in the Gramineae, predating its divergence, and a second WGD occurred in maize during its evolution.
In this study we compared the fate of the genes involved in the core pathway of starch biosynthesis following the ancient
and second WGDs in maize and rice. In total, thirty starch synthesis genes were detected in the maize genome, which covered
all the starch synthesis gene families encoded by 27 genes in rice. All of these genes, except ZmGBSSIIb and ZmBEIII, are anchored within large-scale synteny blocks of rice and maize chromosomes. Previous findings and our results indicate
that two of the current copies of many starch synthesis genes (including AGPL, AGPS, GBSS, SSII, SSIII, and BEII) probably arose from the ancient WGD in the Gramineae and are still present in the maize and rice genome. Furthermore, two
copies of at least six genes (AGPS1, SSIIb, SSIIIb, GBSSII, BEI, and ISA3) appear to have been retained in the maize genome after its second WGD, although complete coding regions were only detected
among the duplicate sets of AGPS1, SSIIb, and SSIIIb. The expression patterns of the remaining duplicate sets of starch synthesis genes (AGPL1/2, AGPS1/2, SSIIa/b, SSIIIa/b,
GBSSI/II, and BEIIa/b) differ in their expression and could be classified into two groups in maize. The first group is mainly
expressed in the endosperm, whereas the second is expressed in other organs and the early endosperm development. The four
duplicate sets of ZmGBSSII, ZmSSIIb, ZmSSIIIb and AGPS1, which arose from the second WGD diverged in gene structure and/or expression patterns in maize. These results indicated
that some duplicated starch synthesis genes were remained, whereas others diverged in gene structure and/or expression pattern
in maize. For most of the duplicated genes, one of the copies has disappeared in the maize genome after the WGD and the subsequent
“diploidization”.
Electronic supplementary material The online version of this article (doi:) contains supplementary material, which is available to authorized users. 相似文献