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TargetFinder: a software for antisense oligonucleotide target site selection based on MAST and secondary structures of target mRNA 总被引:2,自引:0,他引:2
SUMMARY: TargetFinder is a PC/Windows program for interactive effective antisense oligonucleotide (AO) selection based on mRNA accessible site tagging (MAST) and secondary structures of target mRNA. To make MAST result intuitive, both the alignment result and tag frequency profile is illustrated. As theoretical reference, secondary structure and single strand probability profile of target mRNA is also represented. All of these sequences and profiles are displayed in aligned mode, which facilitates identification of the accessible sites in target mRNA. Graphical, user-friendly interface makes TargetFinder a useful tool in AO target site selection. AVAILABILITY: The software is freely available at http://www.bioit.org.cn/ao/targetfinder.htm CONTACT: sqwang@nic.bmi.ac.cn. 相似文献
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Proteins that bind to the yeast rDNA enhancer 总被引:21,自引:0,他引:21
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Identification of sparsely distributed clusters of cis-regulatory elements in sets of co-expressed genes 总被引:4,自引:0,他引:4
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Kreiman G 《Nucleic acids research》2004,32(9):2889-2900
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A graph-based approach to systematically reconstruct human transcriptional regulatory modules 总被引:2,自引:0,他引:2
Yan X Mehan MR Huang Y Waterman MS Yu PS Zhou XJ 《Bioinformatics (Oxford, England)》2007,23(13):i577-i586
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