共查询到20条相似文献,搜索用时 381 毫秒
1.
2.
Schwartz-Albiez R 《Journal of biological regulators and homeostatic agents》2000,14(4):286-287
3.
4.
5.
6.
Volume Contents
Contents Volume 76 2004 相似文献8.
9.
10.
11.
12.
13.
14.
15.
16.
17.
《Plant Cell, Tissue and Organ Culture》2004,76(3):299-299
Authors Index
Author Index Volume 76 2004 相似文献18.
19.
20.
Awasthi S Sharma R Yang Y Singhal SS Pikula S Bandorowicz-Pikula J Singh SV Zimniak P Awasthi YC 《Acta biochimica Polonica》2002,49(4):855-867
We have recently demonstrated that a previously known Ral-binding GTPase activating protein, RLIP76, can also catalyze ATP-dependent transport of various structurally unrelated xeno- and endobiotics irrespective of their net charge (Awasthi et al., 2000, Biochemistry, 39: 9327). RLIP76 is a non-ATP binding cassette (ABC) protein but it has two ATP-binding sites and shows basal ATPase activity which is stimulated in the presence of its transport substrates (allocrites) such as doxorubicin (DOX) and S-(2,4-dinitrophenyl) glutathione (DNP-SG). Proteoliposomes reconstituted with purified RLIP76 catalyze ATP-dependent, saturable transport of DOX, as well as of glutathione-conjugates including leukotrienes (LTC4) and the GSH-conjugate of 4-hydroxynonenal (GS-HNE). In erythrocytes the majority of transport activity for DOX, GS-HNE, and LTC4 is accounted for by RLIP76. Cells exposed to mild oxidative stress show a rapid and transient induction of RLIP76 resulting in an increased efflux of GS-HNE and acquire resistance to oxidative stress mediated toxicity and apoptosis. Cells transfected with RLIP76 acquire resistance to DOX through increased efflux of the drug suggesting its possible role in the mechanisms of drug-resistance. In this article, we discuss the significance of transport functions of RLIP76 highlighting its role in the defense mechanisms against oxidative injury, and modulation of signaling mechanisms. 相似文献