共查询到20条相似文献,搜索用时 406 毫秒
1.
Michael A Becker H Ralph Schumacher Luis R Espinoza Alvin F Wells Patricia MacDonald Eric Lloyd Christopher Lademacher 《Arthritis research & therapy》2010,12(2):R63
Introduction
The purpose of this study was to compare urate-lowering (UL) efficacy and safety of daily febuxostat and allopurinol in subjects with gout and serum urate (sUA) ≥ 8.0 mg/dL in a six-month trial. 相似文献2.
Shih-Lu Wu Chia-Cheng Li Jaw-Chyun Chen Yi-Jin Chen Ching-Ting Lin Tin-Yun Ho Chien-Yun Hsiang 《Journal of biomedical science》2009,16(1):6-14
Background
Endonuclease G (EndoG), a member of DNA/RNA nonspecific ββα-Me-finger nucleases, is involved in apoptosis and normal cellular proliferation. In this study, we analyzed the critical amino acid residues of EndoG and proposed the catalytic mechanism of EndoG. 相似文献3.
Yi-Ting Wu Che Yi Lin Ming-Yuan Tsai Yi-Hua Chen Yu-Fen Lu Chang-Jen Huang Chao-Min Cheng Sheng-Ping L Hwang 《Journal of biomedical science》2011,18(1):70
Background
β-Lapachone has antitumor and wound healing-promoting activities. To address the potential influences of various chemicals on heart development of zebrafish embryos, we previously treated zebrafish embryos with chemicals from a Sigma LOPAC1280™ library and found several chemicals including β-lapachone that affected heart morphogenesis. In this study, we further evaluated the effects of β-lapachone on zebrafish embryonic heart development. 相似文献4.
S Jane Millward-Sadler Patrick W Costello Anthony J Freemont Judith A Hoyland 《Arthritis research & therapy》2009,11(3):R65-10
Introduction
The aim of this study was to compare the effects of tumour necrosis factor-alpha (TNF-α) and interleukin-1-beta (IL-1β) on protease and catabolic cytokine and receptor gene expression in normal and degenerate human nucleus pulposus cells in alginate culture. 相似文献5.
Introduction
Epigallocatechin-3-gallate (EGCG) is a bioactive polyphenol of green tea and exerts potent anti-inflammatory effects by inhibiting signaling events and gene expression. Interleukin-1beta (IL-1β) is the principal cytokine linked to cartilage degradation in osteoarthritis (OA). The objective of this study was to evaluate the global effect of EGCG on IL-1β-induced expression of proteins associated with OA pathogenesis in human chondrocytes. 相似文献6.
7.
Background
The mechanism by which duplicate genes originate – whether by duplication of a whole genome or of a genomic segment – influences their genetic fates. To study events that trigger duplicate gene persistence after whole genome duplication in vertebrates, we have analyzed molecular evolution and expression of hundreds of persistent duplicate gene pairs in allopolyploid clawed frogs (Xenopus and Silurana). We collected comparative data that allowed us to tease apart the molecular events that occurred soon after duplication from those that occurred later on. We also quantified expression profile divergence of hundreds of paralogs during development and in different tissues. 相似文献8.
Nygaard V Løland A Holden M Langaas M Rue H Liu F Myklebost O Fodstad Ø Hovig E Smith-Sørensen B 《BMC genomics》2003,4(1):11
Background
A limiting factor of cDNA microarray technology is the need for a substantial amount of RNA per labeling reaction. Thus, 20–200 micro-grams total RNA or 0.5–2 micro-grams poly (A) RNA is typically required for monitoring gene expression. In addition, gene expression profiles from large, heterogeneous cell populations provide complex patterns from which biological data for the target cells may be difficult to extract. In this study, we chose to investigate a widely used mRNA amplification protocol that allows gene expression studies to be performed on samples with limited starting material. We present a quantitative study of the variation and noise present in our data set obtained from experiments with either amplified or non-amplified material. 相似文献9.
Can B. Aktas Melissa M. Bilec 《The International Journal of Life Cycle Assessment》2012,17(3):337-349
Purpose
Many life cycle assessment (LCA) studies do not adequately address the actual lifetime of buildings and building products, but rather assume a typical value. The goal of this study was to determine the impact of lifetime on residential building LCA results. Including accurate lifetime data into LCA allows a better understanding of a product’s environmental impact that would ultimately enhance the accuracy of LCA results. 相似文献10.
Shuyu Wu Eirini Chouliara Lars Bogø Jensen Anders Dalsgaard 《Acta veterinaria Scandinavica》2008,50(1):38
Background
Screening and enumeration of antimicrobial resistant Escherichia coli directly from samples is needed to identify emerging resistant clones and obtain quantitative data for risk assessment. Aim of this study was to evaluate the performance of 3M™ Petrifilm™ Select E. coli Count Plate (SEC plate) supplemented with antimicrobials to discriminate antimicrobial-resistant and non-resistant E. coli. 相似文献11.
Evelien Schurgers Hilde Kelchtermans Tania Mitera Lies Geboes Patrick Matthys 《Arthritis research & therapy》2010,12(1):R31
Introduction
The goal of this study is to analyze the potential immunosuppressive properties of mesenchymal stem cells (MSC) on T cell proliferation and in collagen-induced arthritis (CIA). An additional aim is to investigate the role of interferon-γ (IFN-γ) in these processes. 相似文献12.
Background
Time series microarray experiments are widely used to study dynamical biological processes. Due to the cost of microarray experiments, and also in some cases the limited availability of biological material, about 80% of microarray time series experiments are short (3–8 time points). Previously short time series gene expression data has been mainly analyzed using more general gene expression analysis tools not designed for the unique challenges and opportunities inherent in short time series gene expression data. 相似文献13.
Background
High-throughput genomic research tools are becoming standard in the biologist's toolbox. After processing the genomic data with one of the many available statistical algorithms to identify statistically significant genes, these genes need to be further analyzed for biological significance in light of all the existing knowledge. Literature mining – the process of representing literature data in a fashion that is easy to relate to genomic data – is one solution to this problem. 相似文献14.
Background
The aim of this study was to analyze the cell-specific expression of E- and N-cadherin and β-catenin in developing human lung tissues from 12 to 40 weeks of gestation. 相似文献15.
Cheng-Dean Shih 《Journal of biomedical science》2009,16(1):60-9
Background
Apart from their well-known peripheral cardiovascular effects, emerging evidence indicates that estrogen acts as a modulator in the brain to regulate cardiovascular functions. The underlying mechanisms of estrogen in central cardiovascular regulation, however, are poorly understood. The present study investigated the cardiovascular effects of 17β-estradiol (E2β) in the rostral ventrolateral medulla (RVLM), where sympathetic premotor neurons are located, and delineated the engagement of nitric oxide (NO) in E2β-induced cardiovascular responses. 相似文献16.
Sohrab?P?Shah David?YM?He Jessica?N?Sawkins Jeffrey?C?Druce Gerald?Quon Drew?Lett Grace?XY?Zheng Tao?Xu BF?Francis?Ouellette
Background
We present Pegasys – a flexible, modular and customizable software system that facilitates the execution and data integration from heterogeneous biological sequence analysis tools. 相似文献17.
Srinivas V Seekallu Behzad M Toosi Norman C Rawlings 《Reproductive biology and endocrinology : RB&E》2009,7(1):78
Background
In the ewe, ovarian antral follicles emerge or grow from a pool of 2–3 mm follicles in a wave like pattern, reaching greater than or equal to 5 mm in diameter before regression or ovulation. There are 3 or 4 such follicular waves during each estrous cycle. Each wave is preceded by a peak in serum FSH concentrations. The role of pulsatile LH in ovarian antral follicular emergence and growth is unclear; therefore, the purpose of the present study was to further define this role. 相似文献18.
Görel Nyman Stina Marntell Anna Edner Pia Funkquist Karin Morgan Göran Hedenstierna 《Acta veterinaria Scandinavica》2009,51(1):22
Background
Sedation with α2-agonists in the horse is reported to be accompanied by impairment of arterial oxygenation. The present study was undertaken to investigate pulmonary gas exchange using the Multiple Inert Gas Elimination Technique (MIGET), during sedation with the α2-agonist detomidine alone and in combination with the opioid butorphanol. 相似文献19.
Jonathan Eckard Jisen Dai Jing Wu Jinlong Jian Qing Yang Haobin Chen Max Costa Krystyna Frenkel Xi Huang 《Cancer cell international》2010,10(1):28
Background
Young women diagnosed with breast cancer are known to have a higher mortality rate from the disease than older patients. Specific risk factors leading to this poorer outcome have not been identified. In the present study, we hypothesized that iron deficiency, a common ailment in young women, contributes to the poor outcome by promoting the hypoxia inducible factor-1α (HIF-1α and vascular endothelial growth factor (VEGF) formation. This hypothesis was tested in an in vitro cell culture model system. 相似文献20.
The carbon footprint of bread 总被引:1,自引:0,他引:1
Namy Espinoza-Orias Heinz Stichnothe Adisa Azapagic 《The International Journal of Life Cycle Assessment》2011,16(4):351-365