共查询到20条相似文献,搜索用时 15 毫秒
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M. J. Brown 《BMJ (Clinical research ed.)》1997,314(7089):1258-1261
The abundance of drugs now available for treating hypertension, and evidence that small reductions in blood pressure reverse the associated risk of stroke have shifted clinical concerns away from hypertension. However, we do not understand the cause of hypertension in 95% of patients, fail to achieve a normal blood pressure in 50% of patients, and are unable fully to reverse the cardiac and vascular changes that predate the diagnosis and treatment of hypertension. Consequently, hypertension remains the commonest cause of strokes in Britain and of renal failure in the United States. Essential hypertension is a polygenic disease whose understanding can now be advanced through molecular genetic analyses. Several different syndromes are likely to be recognised; most will be due to interactions between genetic and environmental factors, but there are also likely to be further monogenic syndromes in families with multiple affected members. Recognition of these syndromes will permit accurate genetic prediction of prognosis and optimal treatment and perhaps lead to new and more powerful classes of antihypertensive treatment. 相似文献
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S. Krishna 《BMJ (Clinical research ed.)》1997,315(7110):730-732
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A collection of genetic lines in 8 reproductively isolated Pichia species has been created. The above data have permitted realizing intraspecific hybridization and showing normal meiotic segregation of auxotrophic markers. 相似文献
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S. J. Russell 《BMJ (Clinical research ed.)》1997,315(7118):1289-1292
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J. Wilding 《BMJ (Clinical research ed.)》1997,315(7114):997-1000
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Age, growth, and reproductive biology of the blackbelly rosefish from the Carolinas, U.S.A. 总被引:1,自引:0,他引:1
Otoliths and gonads of blackbelly rosefish Helicolenus dactylopterus dactylopterus were collected from the commercial fishery off the Carolinas in 1994–1997. Opaque bands on transverse sections of otoliths were determined to be annuli by analysis of marginal increments. Opaque zone formation occurs between July and January. Ages ranged from 7 to 30 years. Blackbelly rosefish have intraovarian gestation. Fertilization is internal, as free spermatozoa were found primarily in resting ovaries from July through early December with peak occurrence in September through November. There was a delay of 1–3 months before fertilization, as oocyte development did not begin until December. Occurrence during January through April of early-celled embryos, the most advanced stage observed, and postovulatory follicles indicated that oocyte development was rapid. Egg development occurs in a clear gelatinous matrix secreted into the ovarian cavity. The reproductive mode is a zygoparous form of oviparity, intermediate between oviparity and viviparity. Population sex ratio departed markedly from 1: 1 for most length intervals. Males were more abundant at lengths >250 mm L T and the overall male: female ratio was 1 : 0·60. 相似文献
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D. Gengry Steele 《American journal of physical anthropology》1976,44(1):158-160