共查询到20条相似文献,搜索用时 15 毫秒
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N Ohsawa 《Human cell》1990,3(2):91-98
Polyamines are recognized as cell growth factors in relation to cell proliferation, differentiation, regeneration and malignant transformation. Polyamines play an important role in the growth of normal cells like vascular endothelial cells and also exert various effects on the proliferation and metastasis of malignant cells. The recent studies on the biosynthesis have clearly elucidated its mechanism at the gane levels, which reflects to the development of the inhibitors of the polyamine biosynthesis. One of the main purposes of the studies on the various polyamine synthesis inhibitors is for the development of new anti-cancer agents, based on the characteristics of the polyamine functions. The clinical effects of several inhibitors, however, have not been shown to be satisfactory and the reason is now the most important research subject in this field. The measurement of the polyamine contents in biological fluids including urine and blood has been shown to be useful as the tumor marker. The recent studies have indicated that the mechanism of increased secretion of urinary polyamines is due to the release from the degraded cancer cells. The results now stimulated the research which aims to elucidate the usefulness of the measurement of urinary polyamines as the parameters of the sensitivity to the anticancer drugs in patients with cancer. 相似文献
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Recent progress in brassinosteroid research 总被引:11,自引:0,他引:11
Jenneth M. Sasse 《Physiologia plantarum》1997,100(3):696-701
The progress of investigations in recent years of the occurrence, analysis, structure/activity relationships, physiology, role in stress responses, and applications of brassinosteroids is reviewed. Their inclusion in the category of plant hormones is now widely accepted, and much more research into the effects of brassinosteroids can be expected in future. 相似文献
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Recent progress in poxvirus research 总被引:6,自引:0,他引:6
B Woodson 《Bacteriological reviews》1968,32(2):127-137
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Recent progress in protocadherin research 总被引:10,自引:0,他引:10
Suzuki ST 《Experimental cell research》2000,261(1):13-18
Protocadherins constitute a large family belonging to the cadherin superfamily and function in different tissues of a wide variety of multicellular organisms. Protocadherins have unique features that are not found in classic cadherins. Expression of protocadherins is spatiotemporally regulated and they are localized at synapses in the CNS. Although protocadherins have Ca(2+)-dependent homophilic interaction activity, the activities are relatively weak. Some protocadherins have heterophilic interaction activity and the cytoplasmic domains associate with the unique cytoplasmic proteins, which are essential for their biological functions. Given the characteristic properties, the large size, and the diversity of members of the protocadherin family, protocadherins may participate in various biological processes. In particular, protocadherins seem to play a central role(s) in the CNS as related to synaptic function. 相似文献
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B Woodson 《Microbiological reviews》1968,32(2):127-137
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苔藓植物生态功能研究新进展 总被引:3,自引:1,他引:3
苔藓植物是一种形体微小、结构简单的高等植物,是水生向陆生的一种过渡形式,是高等植物中最原始的类群.随着研究的发展,人们越来越意识到苔藓植物在生态系统结构和功能中具有非常重要的作用,而且对苔藓在生物监测、水土保持、森林更新等方面已有一些研究和综述.本文针对目前环境科学研究中的一些热点问题,从全球气候变化、生态系统C、N、P循环等方面对近年来苔藓植物的生态功能研究方面的新进展进行了综述,以期加深人们对苔藓的认识并促进苔藓植物生态功能的进一步深入研究. 相似文献
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Chikungunya virus (CHIKV) is an arbovirus transmitted by Aedes mosquitos in tropical and subtropical regions across the world. After decades of sporadic outbreaks, it re-emerged in Africa, Asia, India Ocean and America suddenly, causing major regional epidemics recently and becoming a notable global health problem. Infection by CHIKV results in a spectrum of clinical diseases including an acute self-limiting febrile illness in most individuals, a chronic phase of recurrent join pain in a proportion of patients, and long-term arthralgia for months to years for the unfortunate few. No specific anti-viral drugs or licensed vaccines for CHIKV are available so far. A better understanding of virus-host interactions is essential for the development of therapeutics and vaccines. To this end, we reviewed the existing knowledge on CHIKV’s epidemiology, clinical presentation, molecular virology, diagnostic approaches, host immune response, vaccine development, and available animal models. Such a comprehensive overview, we believe, will shed lights on the promises and challenges in CHIKV vaccine development. 相似文献