Encephalitis after administration of live measles vaccine.

In a previously well child with no evidence of pre-existing immunologic defect a fatal encephalitis developed 10 days after administration of measles vaccine. There was pathologic evidence of an early viral encephalitis characterized by perivascular mononulcear infiltrates. Although the virus was not recovered, the diagnosis of a measles virus infection and encephalitis is supported by the postmortem findings of Warthin-Finkeldey cells in lymphoid tissues, an intranuclear inclusion in the brain and histologic changes of encephalitis.     

Live measles vaccine: a 21 year follow up.

21 years after receiving Schwartz strain live measles vaccine 4500 trial participants showed a continuing high level of protection compared with those who were unvaccinated. Over the last seven years of the follow up no cases of measles were reported in vaccinated participants who had had close contact with the disease. Immunity induced by the vaccine seems to survive the challenge of close contact with measles in young children, even after 21 years.     

麻疹疫苗生产工艺的改进研究

对麻疹疫苗生产工艺进行了改进研究,在病毒培养过程中,以病毒生长稳定剂替代白蛋白,减少维持液加量,延长病毒培养时间并缩短病毒释放时间,提高了病毒原液的滴度,由此可使分装量减少,而每一剂量中实际病毒含量并不减少,从而使麻疹疫苗的冻干条件得到改善,采用改进工艺后,麻疹疫苗的质量,中间产品和成品合格率均有较大的提高。