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Aims
Panduratin A isolated from Boesenbergia pandurata (Roxb.) has been reported to have antioxidant, anti-inflammatory, and anti-allergic activities. However, the effect of panduratin A on atopic dermatitis (AD) has not been studied. In the present study, we investigated the efficacy of panduratin A, an activator of peroxisome proliferator-activated receptors (PPAR) α/δ, using oxazolone-induced AD-like model in hairless mice.Main methods
To determine PPARα/δ activation of panduratin A, HaCaT, Hs68, and COS-7 cells were treated with panduratin A, then PPARα/δ and PPAR response element (PPRE) activities were assessed with a reporter gene assay. For the in vivo study, oral administration of panduratin A was performed for 4 weeks, with oxazolone treatment every other day. The efficacy of panduratin A on parameters of oxazolone-induced AD was assessed physiologically, morphologically, and immunologically.Key findings
Panduratin A increased PPARα/δ and PPRE activation both in vitro and in vivo. Panduratin A attenuated dermatitis-associated barrier damage as demonstrated by transepidermal water loss, erythema, and filaggrin expression. Furthermore, infiltration of inflammatory cells and epidermal thickness in the skin were decreased. Panduratin A decreased serum immunoglobulin (Ig) E and interleukin-4 levels but increased IgG2a and interferon-γ levels. In addition, panduratin A decreased inflammation-associated molecules in the skin. Panduratin A also decreased Th2-associated molecules and increased Th1/regulatory T cell (Treg)-associated molecules in the spleen.Significance
Panduratin A showed a beneficial effect on AD by modulating Th1/Th2/Treg-associated immune response and is a potential candidate for treating AD. 相似文献3.
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A photosynthetically competent mutant strain of Rhodopseudomonas spheroides was isolated. In addition to bacteriochlorophyll, this organism produced particle-bound precursor 4-vinylprotochlorophyllide. The spectral characteristics of the pigment complex(es) accumulated in the culture medium were very variable. The spectral form occurring within the bacteria was characterized from fluorescence data. Its particle weight, 130 000, was determined by Sephadex G200 filtration. The main components of the complex were protein, lipid and pigment (6.8 : 6 : 1, w/w). As indicated by qualitative analysis, the lipid components were characteristic constituents of the photosynthetic membrane.Kinetics of pigments synthesis showed that the total pigment synthesis was not affected by the mutation; bacteriochlorophyll content was always lower in the mutant than in the parent strain. The repigmentation process was followed by fluorescence emission. The results indicated that the mutation affected membrane component synthesis required for the bacteriochlorophyll(ide) incorporation.The pigment complex was concluded to be an authentic intermediate in photosynthetic apparatus morphogenesis. The reasons for its excretion are discussed. 相似文献
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Leigh Binford 《The journal of the Royal Anthropological Institute》2020,26(3):669-670
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Corine Vedrine 《The journal of the Royal Anthropological Institute》2020,26(4):886-887
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《Molecular medicine today》1996,2(10):408-409
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James C. Tarr Michael R. Wood Meredith J. Noetzel Bruce J. Melancon Atin Lamsal Vincent B. Luscombe Alice L. Rodriguez Frank W. Byers Sichen Chang Hyekyung P. Cho Darren W. Engers Carrie K. Jones Colleen M. Niswender Michael W. Wood Nicholas J. Brandon Mark E. Duggan P. Jeffrey Conn Thomas M. Bridges Craig W. Lindsley 《Bioorganic & medicinal chemistry letters》2018,28(17):3014
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《Trends in genetics : TIG》1997,13(11):435
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Mario Katić 《The journal of the Royal Anthropological Institute》2019,25(2):407-408