Microbe–microbe interactions in mixed culture food fermentations

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Highlights► Microbial interactions in food fermentations are crucial for product functionality. ► Complex microbial consortia tolerate more variation in the environment. ► Knowledge of communities of fermenting microbes drives diversification of starter cultures. ► Use of complex starter cultures requires new propagation methodologies. ► Immobilised cell technology is a high potential solution for propagating complex cultures.     

Quantitative Proteomics of the 2016 WHO Neisseria gonorrhoeae Reference Strains Surveys Vaccine Candidates and Antimicrobial Resistance Determinants

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Highlights

• •Quantitative proteomes of the 2016 WHO Neisseria gonorrhoeae reference strains.
• •Novel gonorrhea vaccine candidates and potential global proteomic AMR markers.
• •First large-scale proteomic profiling of gonorrhea vaccine candidates and AMR.
• •A reference proteomics databank for gonococcal vaccine and AMR research endeavors.

     

The metabolic profile of tumors depends on both the responsible genetic lesion and tissue type

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Highlights? MYC and MET affect glucose and glutamine metabolism differently in the liver ? Tissue context affects the outcome of metabolic reprogramming by MYC ? MYC overexpression sensitizes cells to inhibition of Gls1 glutaminase     

Evolutionary Shift from Fighting to Foraging in Blind Cavefish through Changes in the Serotonin Network

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Highlights? Astyanax cavefish have lost aggressive behavior during adaptation to life in the dark ? Astyanax raphe serotonergic neurons control social behavior ? Astyanax hypothalamic serotonergic neurons control homeostatic functions ? The development of a neuronal network links to the behaviors it controls     

Fertility and Germline Stem Cell Maintenance under Different Diets Requires nhr-114/HNF4 in C. elegans

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Highlights? C. elegans fertility on different diets requires nuclear receptor nhr-114 activity ? Somatic NHR-114 is necessary to maintain germline stem cells under different diets ? NHR-114 might mediate a detoxification response that preserves the germline ? Bacterial tryptophan metabolites may underlie diet-sensitive nhr-114(?) sterility     

Deep Brain Photoreceptors Control Light-Seeking Behavior in Zebrafish Larvae

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Highlights? Larvae aggregate in the light even after loss of retinal and pineal photoreception ? Dark-driven photokinesis is absent in eyeless otpa mutant larvae ? The melanopsin opn4a is coexpressed with otpa and selectively lost in otp mutants ? otpa neurons of the preoptic area are deep brain photoreceptors for dark photokinesis     

New opportunities by synthetic biology for biopharmaceutical production in Pichia pastoris

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Highlights► The application of Pichia pastoris for biopharmaceutical production is described. ► Synthetic biology approaches and perspectives to improve production are reviewed. ► Glycoengineering efforts to produce humanized, uniform glycoproteins are covered. ► The design and application of synthetic promoter variants are highlighted. ► The molecular toolbox available for synthetic biology in P. pastoris is discussed.     

Functional Insights Into Protein Acetylation in the Hyperthermophilic Archaeon Sulfolobus islandicus,

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Highlights

• •Protein acetylation at Lys residues and the N terminus occurs widely in Sulfolobus.
• •SisPat preferentially acetylates a group of acyl-CoA synthetases.
• •SisArd1 acetylates the majority of the acetylated N termini identified in the cell.
• •SisArd1, but not SisPat, is required for the optimal growth of the organism.

     

RNA helicases in bacteria

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Nanotubes in biological applications

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Metabolic versatility in methanogens

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Mycobacterium tuberculosis activates the DNA-dependent cytosolic surveillance pathway within macrophages

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Highlights? M. tuberculosis permeabilizes phagosomes and activates cytosolic signaling pathways ? Host cytoplasmic DNA receptors sense M. tuberculosis extracellular DNA ? DNA recognition activates the STING/TBK1/IRF3 pathway ? Cytosolic sensing promotes M. tuberculosis infection     

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

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Highlights? Splice-isoform switching favors prosurvival BCL2 family expression in human BC ? BC LSCs are quiescent and TKI-resistant in the marrow niche ? Sabutoclax, a pan-BCL2 inhibitor, enhances TKI sensitivity of bone marrow BC LSCs     

Biotechnological opportunities in biosurfactant production

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Amino acid misincorporation in recombinant biopharmaceutical products

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Mutations in RNA methylating enzymes in disease

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Recent advances in biological production of sugar alcohols

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