安氏Ⅰ类错合拔牙与非拔牙矫治对口唇形态影响的研究

目的：研究安氏Ⅰ类错合拔牙与非拔牙矫治对口唇形态的影响。方法：从直丝弓矫治的AngleⅠ类错合患者治疗前后的X线侧位片中随机选取拔除4个第一前磨牙患者15例（A组）,非拔牙矫治患者15例（B组）,经X线头影软组织测量分析比较矫治前后拔牙组与非拔牙组口唇形态的变化,对所得数据进行统计学处理。结果：拔牙矫治后上下唇的突度有明显改善,平均减少1.42和2.03mm;上下唇的长度也平均增加0.51和1.58mm;非拔牙矫治患者治疗后鼻唇角、下唇突度、上下唇长度均有增加,但矫治前后无统计学差异。结论：拔牙矫治有利于减小上下唇突度从而改善软组织侧貌。     

GMD应用于安氏II类错[牙合]非拔牙矫治的临床分析

目的：探讨安氏11类错[牙合]非拔牙矫治中GMD矫治器的疗效和适应症。方法：选择36例恒牙早期安氏Ⅱ类病例,主要表现为以乳磨牙早失形成的磨牙近移或上牙列轻中度拥挤的的非拔牙患者为研究对象,通过运用GMD推磨牙装置远移磨牙开辟后牙间隙。结果：36倒患者中除1例因上切牙唇倾致患者对面形不满意而改行拔牙矫治外其余患者均取得了较好的疗效。第一磨牙平均远移5．6mm,远移到位平均4—5个月。磨牙建立中性关系。结论：GMD装置是一种快速有效的推磨牙向后的矫治器,但要掌握好适应症才能取得成功。     

GMD 应用于安氏II 类错牙合非拔牙矫治的临床分析

目的:探讨安氏Ⅱ类错非拔牙矫治中GMD矫治器的疗效和适应症。方法:选择36例恒牙早期安氏Ⅱ类病例,主要表现为以乳磨牙早失形成的磨牙近移或上牙列轻中度拥挤的的非拔牙患者为研究对象,通过运用GMD推磨牙装置远移磨牙开辟后牙间隙。结果:36例患者中除1例因上切牙唇倾致患者对面形不满意而改行拔牙矫治外其余患者均取得了较好的疗效。第一磨牙平均远移5.6mm,远移到位平均4-5个月。磨牙建立中性关系。结论:GMD装置是一种快速有效的推磨牙向后的矫治器,但要掌握好适应症才能取得成功。     

钕铁硼永磁体与双阻板矫治器矫治AngleⅢ类错[牙合]

目的：观察双阻板矫治器基础上使用钕铁硼永磁体矫治AngleⅢ类错[牙合]的效果。方法：15例替牙及恒牙早期AngleⅢ类错[牙合]畸形患者,男6例,女9例。年龄9-13岁,平均11.25岁。在双阻板矫治器的上下阻板安放第三代高磁能积稀土永磁体钕铁硼,矫治过程中磁块间距的增加说明疗效,间距加1mm以上考虑加力。治疗前后头颅侧位片及常规头影方法进行分析。结果：与矫治前相比,矫治后ANB角,Ao—Bo距,NA—PA角均增大,差异有统计学意义（P〈0.01）。SNB角减小,差异有统计学意义（P〈0．01）。结论：磁力双阻板矫治器克服了传统矫形装置的缺点,从而能获得持续的矫形力,磁力调整易于控制,便于临床开展。     

钕铁硼永磁体与双阻板矫治器矫治Angle Ⅲ类错(牙合)

目的:观察双阻板矫治器基础上使用钕铁硼永磁体矫治AngleⅢ类错牙合的效果.方法:15例替牙及恒牙早期AngleⅢ类错牙合畸形患者,男6例,女9例.年龄9-13岁,平均11-25岁.在双阻板矫治器的上下阻板安放第三代高磁能积稀土永磁体钕铁硼,矫治过程中磁块间距的增加说明疗效,间距加1mm以上考虑加力.治疗前后头颅侧位片及常规头影方法进行分析.结果:与矫治前相比,矫治后ANB角,Ao-Bo距,NA-PA角均增大,差异有统计学意义(P<0.01).SNB角减小,差异有统计学意义(P<0.01).结论:磁力双阻板矫治器克服了传统矫形装置的缺点,从而能获得持续的矫形力,磁力调整易于控制,便于临床开展.     

Angle Ⅱ^1类错[牙合]畸形牙弓及基骨形态的测量分析

目的 通过比较上海地区Angle Ⅱ1类及个别正常[牙合]青少年牙、牙弓及基骨形态,为正畸临床诊断和治疗提供理论依据.方法 以上海地区个别正常[牙合]青少年50例（男女各25例）为对照组 以Angle Ⅱ^1类50例（男女各25例）为实验组.分别测量牙量,牙弓宽度及长度,基骨宽度及长度.用SPSS.13.0统计软件对测量结果进行统计分析.结果 （1）牙弓形态：实验组上颌中段和后段牙弓宽度显著减小,上颌前段,下颌各段牙弓宽度与对照组无显著差异.上下颌各段牙弓长度显著增加.（2）基骨形态：实验组上颌基骨宽度显著减小,基骨长度显著增加 下颌基骨形态与对照组无显著差异.（3）牙量：实验组上下颌牙量均显著增加.结论 （1）Angle Ⅱ^1类患者未发现尖牙区和下颌牙弓狭窄,提示临床上尽量不要轻易扩展上颌尖牙区和下颌牙弓宽度.（2）Angle Ⅱ^1类患者上颌牙弓和基骨均显狭长.     

口腔正畸MIA技术对青少年安氏Ⅱ类错[牙合]畸形患者对龈沟液MMP-2表达水平的影响

目的:探讨口腔正畸微螺钉种植体支抗(Microscrew implant anchor,MIA)技术对青少年安氏Ⅱ类错[牙合]畸形患者对龈沟液基质金属蛋白酶(Matrix metalloproteinase,MMP)-2表达水平的影响。方法:2016年1月1日至2019年12月31日选择在本院诊治的青少年安氏Ⅱ类错[牙合]畸形患者86例,根据治疗方法把患者分为MIA组与对照组,各43例,对照组给予头帽口外弓支抗技术结合直丝弓矫治器治疗,MIA组给予MIA技术结合直丝弓矫治器治疗,检测龈沟液MMP-2表达水平变化情况。结果:MIA组正畸后6个月的总有效率为97.7%,显著高于对照组的81.4%(P<0.05)。两组正畸后6个月的SNA角、OB与OJ值低于正畸前,MIA组低于对照组(P<0.05),两组正畸前后SNB角在组内与组间对比差异都无统计学意义(P>0.05)。两组正畸后6个月的龈沟液MMP-2值低于正畸前,MIA组低于对照组(P<0.05)。结论:口腔正畸MIA技术在青少年安氏Ⅱ类错[牙合]畸形患者的应用能抑制龈沟液MMP-2的表达,有利于改善患者的头颅与牙齿的X线指标,从而促进提高治疗效果。     

Angle Ⅱ~1类错畸形牙弓及基骨形态的测量分析

目的通过比较上海地区AngleⅡ1类及个别正常青少年牙、牙弓及基骨形态,为正畸临床诊断和治疗提供理论依据。方法以上海地区个别正常青少年50例(男女各25例)为对照组;以AngleⅡ~1类50例(男女各25例)为实验组。分别测量牙量,牙弓宽度及长度,基骨宽度及长度。用SPSS.13.0统计软件对测量结果进行统计分析。结果(1)牙弓形态:实验组上颌中段和后段牙弓宽度显著减小,上颌前段,下颌各段牙弓宽度与对照组无显著差异。上下颌各段牙弓长度显著增加。(2)基骨形态:实验组上颌基骨宽度显著减小,基骨长度显著增加;下颌基骨形态与对照组无显著差异。(3)牙量:实验组上下颌牙量均显著增加。结论(1)AngleⅡ~1类患者未发现尖牙区和下颌牙弓狭窄,提示临床上尽量不要轻易扩展上颌尖牙区和下颌牙弓宽度。(2)AngleⅡ~1类患者上颌牙弓和基骨均显狭长。     

T4K矫治器治疗替牙早期Ⅱ类错合患儿的临床疗效以及预后研究

目的:研究T4K矫治器治疗替牙早期Ⅱ类错合患儿的临床疗效以及预后。方法:选取从2015年2月到2017年3月在我院接受治疗的48例替牙早期Ⅱ类错合患儿进行研究。采用T4K矫治器治疗患儿6个月,对比患儿治疗前及治疗6个月后的模型测量值、X线头影测量数据以及上面高、下面高、下面高比例,随访3年,分析X线头颅侧位片的检测数据。结果:患儿治疗6个月后的前牙覆合值、前牙覆盖值、上牙弓拥挤度、下牙弓拥挤度均较治疗前明显更低,上牙弓宽度和下牙弓宽度较治疗前明显更高,差异均有统计学意义(均P0.05)。治疗6个月后患儿的SNA角、ANB角以及U1-SN角和覆盖均较治疗前明显降低,SNB角、L1-MP角以及U1-L1角和下颌平面角均较治疗前明显升高,差异均有统计学意义(均P0.05)。治疗6个月后患儿的上面高、下面高以及下面高比例均较治疗前明显增加,差异均有统计学意义(均P0.05)。随访3年显示,ANB角和L1-MP角较治疗6个月后明显降低(P0.05),而SNB角、U1-L1角、下颌平面角、上面高、下面高、下面高比例、覆盖均较治疗6个月后明显增高(P0.05)。结论:应用T4K矫治器对替牙早期Ⅱ类错合患儿进行治疗的疗效较好,有利于其康复和预后,值得在临床上给予相应的推广。     

骨性Ⅲ类错合畸形患者正颌术后呼吸道情况随访调查

目的：通过评估骨性Ⅲ错合畸形患者正颌手术后睡眠时期的呼吸功能情况,研究该类患者正颌手术后存在呼吸道梗阻的可能性。为临床治疗提供依据。方法：分析56例接受正颌手术的骨性Ⅲ类错合畸形患者的术前及术后1周、1月、3月和术后6月的多导睡眠图报告。设计问卷调查表评估手术影响日间嗜睡度的变化。从PSG报告上获得的术前术后有代表性的2项参数睡眠呼吸暂停低通气指数与最低氧饱和度分别进行比较。结果：数据显示术前和术后AHI指数及SpO2无显著性差异（统计学上无差异）。54例病人术后均未出现睡眠呼吸障碍症状。2例病人术后出现睡眠时期打鼾,但术后随访6月后打鼾逐渐消失。结论：骨性Ⅲ类错合畸形患者正颌术后无明显呼吸道梗阻症状。但若患者同时具有超重、短颈、舌体大等其他危险因素及仅行下颌骨后退手术可能导致睡眠呼吸暂停低通气综合症的发生。     

Morphological features of Class I,II and III malocclusions of Saudi adolescents

AimsThis cross-sectional study compared and contrasted the morphological characteristics of Class I, II and III malocclusions in an adolescent Saudi population.MethodsAdolescent Saudis with Angle’s Class I, II and III malocclusions were selected from orthodontic patients’ records. Angular and linear measurements were compared between the three groups. Cephalometric analysis was performed using the VistadentOC® software. Multifactorial ANOVA for angular and linear measurements between and within groups.ResultsOrthodontic records of 300 patients were included. There was no significant difference between and within groups in age and distribution of Angle’s classification, p > 0.05. Multifactorial ANOVA showed that there were significant interactions between gender and malocclusions in skeletal, dental and soft tissue measurements, p < 0.05. There were significant differences in the sagittal and vertical skeletal measurements between groups, p < 0.05. The dental measurements were also significantly different in most of the measurements (p < 0.05). Moreover, there were significantly different readings among the groups in the soft tissue analysis.ConclusionMorphological characteristics of adolescent Saudis show unique differences between gender and malocclusions, more so in Class III malocclusions. Class II and III malocclusions also show skeletal differences amongst the groups.     

PKD1基因与抑癌基因P53多态性与非综合征性唇腭裂的关联研究

目的:探讨多囊性肾病基因1(polystic kidney disease,PKD1)多态位点rs8049367与抑癌基因P53(anti-oncogene P53)多态位点rs4791774单核苷酸多态性与中国北方人群非综合征性唇腭裂(NSCL/P)的相关性。方法:运用聚合酶链式反应-连接酶检测反应(PCR-LDR)的检测方法,对602例NSCL/P患者和510例对照人群的PKD1基因的rs8049367位点和抑癌基因P53的rs4791774位点进行基因分型。利用SPSS12.0软件分析PKD1基因,抑癌基因P53多态性与NSCL/P的相关性。结果:rs8049367位点和rs4791774位点基因型及基因频率在两组的分布中差异无统计学意义(P0.05)。结论:PKD1基因的rs8049367位点和抑癌基因P53的rs4791774位点单核苷酸多态性可能与中国北方人群非综合征性唇腭裂的发生无相关性。     

黔北人群TGFα基因多态性与非综合征性唇腭裂的相关性研究

本研究旨在探讨黔北地区人群TGFα基因3个SNP位点的多态性及其与非综合征性唇腭裂的相关性。采用PCR和测序方法对86个对照儿童(其中核心家系41例)和116个NSCL/P儿童(其中核心家系52例)的TGFα基因rs11466297、rs473698和rs115055578 3个SNP位点进行扩增和测序;对样本群体进行Hardy-weinberg平衡检测,对2组人群进行基因型频率、等位基因频率比较及OR分析;对病例组核心家系进行HHRR和TDT检验。对照组与病例组人群rs11466297基因型均为AA野生型,rs473698位点包含GG型、GC型和CC型,rs115055578位点基因型均为GG野生型。对于rs473698位点,对照组和病例组均符合Hardy-Weinberg平衡法则(p>0.05),2组人群的基因型和等位基因频率分布差异均无统计学意义(p<0.05);rs473698位点未发现传递不平衡现象(p>0.05)。黔北地区人群TGFα基因rs11466297和rs115055578位点以野生纯合型为主,rs473698位点具有多态性,但其多态性与黔北地区人群区非综合征性唇腭裂的发生可能没有相关性。     

On the Relative Content of G,C Bases in Codons of Amino Acids Corresponding to Class I and II Aminoacyl-tRNA Synthetases

We have analyzed the relative G,C content from protein coding regions of 530 organisms and found that the ratio of the G,C content of the codons of the amino acids correspondingto Class II and Class I aminoacyl-tRNA synthetases decreases in a statistically significant way from prokaryotes to animals.This can be interpreted assuming that an initial asymmetry between the G,C content of codons of Class I and II amino acids existed and has decreased in the course of evolution.     

Seed treatment with growth regulators and crop productivity. I. 2,4-D as an inducer of salinity-tolerance in wheat (Triticum aestivum L.)

The paper investigates how the apoplastic route of ion transfer is affected by the outermost cortex cell layers of a primary root. Staining of hand-made cross sections with aniline blue in combination with berberine sulfate demonstrated the presence of casparian bands in the endo- and exodermis, potentially being responsible for hindering apoplastic ion movement. The use of the apoplastic dye Evan's Blue allowed viewing under a light microscope of potential sites of uncontrolled solute entry into the apoplast of the root cortex which mainly consisted of injured rhizodermis and/or exodermis cells. The distribution of the dye after staining was highly comparable to EDX analyses on freeze-dried cryosectioned roots. Here, we used Rb+ as a tracer for K+ in a short-time application on selected regions of intact roots from intact plants. After subsequent quench-freezing with liquid propane the distribution of K+ and Rb+ in cell walls was detected on freeze-dried cryosections by their specific X-rays resulting from the incident electrons in a SEM. All such attempts led to a single conclusion, namely, that the walls of the two outermost living cell sheaths of the cortex largely restrict passive solute movements into the apoplast. The ring of turgescent living rhizodermis cells in the root tip region forms the first barrier. With increasing distance to the root tip, in the course of their maturation resp. degradation, this particular function of the rhizodermis cells is replaced by the hypodermis resp. exodermis. Furthermore, the restriction of apoplastic ion flow by the outermost cortex cell layers is rather effective but not complete. Thus, the solute transfer into the stele is mainly restricted by the casparian bands of the endodermis. The overall conclusion is that the resistances of the rhizodermis and exodermis are additive to the endodermis in their role of regulating the apoplastic solute movement across roots. This revised version was published online in August 2006 with corrections to the Cover Date.     

牙周炎患者正畸治疗前后龈沟液中弹性蛋白酶的变化

摘要 目的：探讨牙周炎患者正畸治疗前后龈沟液中弹性蛋白酶的变化价值,希望为早期预测患者预后提供参考。方法：2016年12月到2019年10月选择在本院就诊的牙周炎患者68例作为研究对象,所有患者都给予正畸治疗,检测正畸治疗前后弹性蛋白酶、探诊深度(probing depth,PD)、出血指数(bleeding on probing,BOP)、附着丧失(attachment loss,AL)的变化,记录患者的病情变化、判定预后并进行相关性分析、影响因素分析。结果：所有患者完成治疗,对于正畸治疗的美观、固位、稳定性均满意。治疗后1个月与治疗后3个月患者的PD、BOP、AL都低于治疗前(P<0.05),治疗后3个月也低于治疗后1个月(P<0.05)。治疗后1个月与治疗后3个月患者的龈沟液弹性蛋白酶值都低于治疗前(P<0.05),治疗后3个月也低于治疗后1个月(P<0.05)。Spearman分析显示治疗前与治疗后3个月的龈沟液弹性蛋白酶变化差值与PD、BOP、AL变化差值存在显著正相关性(P<0.05)。多因素Logistic回归显示PD、BOP、AL变化差值作为影响龈沟液弹性蛋白酶变化差值的主要因素(P<0.05)。结论：牙周炎患者正畸治疗前后龈沟液中弹性蛋白酶水平显著下降,与患者的病情变化显著相关,也是反映与预测患者预后的重要指标。     

Changes in plasma oestradiol-17beta, progesterone, testosterone, LH and fertility after treatment with I.C.I. 80, 996.

Fifty heifers were twice injected with I.C.I. 80, 996 and inseminated 72 h and 96 h after the second administration. Twenty eight of them (56%) became pregnant. Changes in plasma oestradiol-17 beta, progesterone and LH concentrations around the oestrus following the second injection were similar to those occurring in spontaneous oestrus. The pattern of testosterone secretion resembled that of oestradiol;-17 beta. The highest testosterone concentration (135 +/- 24 pg/ml) was measured on the third day after treatment with I.C.I. 80, 996.     

Changes in the Mutagenic and Estrogenic Activities of 17β-Estradiol after Treatment with Nitrite

We determined the changes in the mutagenic and estrogenic activities of 17β-estradiol after a nitrite treatment. Nitrite-treated 17β-estradiol showed mutagenic activities toward Salmonella typhimurium strains TA 100 and TA 98. We confirmed that nitrite-treated 17β-estradiol generated radicals from the results of an analysis of electron spin resonance. By applying an instrumental analysis, we identified 2-nitro-17β-estradiol to have been formed in the reaction mixture. 2-Nitro-17β-estradiol did not exhibit mutagenic activities toward Salmonella typhimurium strains, suggesting that other mutagens might have been formed in the reaction mixture. The clastogenic properties of nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol were analyzed by a micronucleus test with male ICR mice. Nitrite-treated 17β-estradiol and 2-nitro-17β-estradiol induced a significantly higher frequency of micronucleated reticulocytes in mice. The estrogenic activity of 2-nitro-17β-estradiol was found to be lower than that of 17β-estradiol. These data suggest that a daily oral intake of 17β-estradiol and nitrite might induce the formation of mutagenic compounds in our body.