共查询到20条相似文献,搜索用时 46 毫秒
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Alternative splicing has an important role in the tissue-specific regulation of gene expression. Here we report that similar to the human NPFF2 receptor, the mouse NPFF2 receptor is alternatively spliced. In human the presence of three alternatively spliced receptor variants were verified, whereas two NPFF2 receptor variants were identified in mouse. The alternative splicing affected the 5′ untranslated region of the mouse receptor and the variants in mouse were differently distributed. The mouse NPFF system may also have species-specific features since the NPFF2 receptor mRNA expression differs from that reported for rat. 相似文献
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T cell receptor-beta mRNA splicing: regulation of unusual splicing intermediates. 总被引:10,自引:3,他引:7 下载免费PDF全文
L Qian L Theodor M Carter M N Vu A W Sasaki M F Wilkinson 《Molecular and cellular biology》1993,13(3):1686-1696
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Avellar MC Honda L Hamil KG Yenugu S Grossman G Petrusz P French FS Hall SH 《Biology of reproduction》2004,71(5):1453-1460
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D S Latchman 《The New biologist》1990,2(4):297-303
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Yatsenko OP Filipenko ML Khrapov EA Voronina EN Kozlov VA Sennikov SV 《Cytokine》2004,28(4-5):190-196
Interleukin-4 and interleukin-6 are multifunctional regulatory proteins, which participate both in haemopoiesis and in immunopoiesis. The alternative splicing of these interleukins in humans is known to proceed in a tissue-specific manner. Additionally, changes in splicing can also be dependent on tissue pathology. In this work, we report on the presence of alternatively spliced mRNA (IL-4delta2mRNA), lacking exon 2, in mouse bone marrow and spleen cells. We find that in unstimulated cells IL-4mRNA levels strongly dominate over IL-4delta2mRNA levels. Both increase in response to stimulation, with the concentration of the alternative variant rising earlier and faster than that of the full-length variant. In all other tissues studied dominance of IL-4delta2mRNA over the full-length variant was not observed. In addition, we find expression of three forms of IL-6 mRNA: the full-length IL-6 mRNA, IL-6Delta3 mRNA, and IL-6Delta5 mRNA in the second and third trimester placenta tissue and in the spleen of mice immunized with a high dose of sheep erythrocytes. It is anticipated that translation of these mRNA variants can generate proteins capable of binding to some subunits of the IL-6 receptor, thus possessing effector function. Alternative splicing is discussed as a source of cytokines with new regulatory properties. 相似文献
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