共查询到20条相似文献,搜索用时 31 毫秒
1.
Sjoerd P Niehof Frank JPM Huygen Rick WP van der Weerd Mirjam Westra Freek J Zijlstra 《Biomedical engineering online》2006,5(1):30
Background
Complex Regional Pain Syndrome type 1 (CRPS1) is a clinical diagnosis based on criteria describing symptoms of the disease. 相似文献2.
Ling-fang He Ting-ting Wang Qian-ying Gao Guang-feng Zhao Ya-hong Huang Li-ke Yu Ya-yi Hou 《Journal of biomedical science》2011,18(1):39
Background
Stanniocalcin-1(STC-1) is up-regulated in several cancers including gastric cancer. Evidences suggest that STC-1 is associated with carcinogenesis and angiogenic process. However, it is unclear on the exact role for STC-1 in inducing angiogenesis and tumorigeneisis. 相似文献3.
Fate of Escherichia coli O145 present naturally in bovine slurry applied to vegetables before harvest,after washing and simulated wholesale and retail distribution
下载免费PDF全文
![点击此处可从《Journal of applied microbiology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
M.L. Hutchison D. Harrison J.F. Heath J.M. Monaghan 《Journal of applied microbiology》2017,123(6):1597-1606
Aims
To determine the fate of Escherichia coli on vegetables that were processed through commercial wash treatments and stored under simulated retail conditions at 4°C or wholesale at fluctuating ambient temperatures (0–25°C, dependent on season).Methods and Results
Bovine slurry that was naturally contaminated with E. coli O145 was applied without dilution or diluted 1:10 using borehole water to growing potatoes, leeks or carrots. Manure was applied 1 week prior to harvest to simulate a near‐harvest contamination event by manure deposition or an application of contaminated water to simulate a flooding event or irrigation from a contaminated water source. At harvest, crops were contaminated at up to 2 log cfu g?1. Washing transferred E. coli into the water of a flotation tank used for potato washing and did not completely remove all traces of contamination from the crop. Manure‐contaminated potatoes were observed to contain 0·72 cfu E. coli O145 g?1 after processing and retail storage. Manure‐contaminated leeks harboured 0·73–1·55 cfu E. coli O145 g?1 after washing and storage. There was no cross‐contamination when leeks were spray washed. Washing in an abrasive drum resulted in less than perfect decontamination for manure‐contaminated carrots. There were five post‐distribution isolations from carrots irrigated with contaminated water 24 h prior to harvest.Conclusions
Standard commercial washing and distribution conditions may be insufficient to reliably control human pathogenic E. coli on fresh produce.Significance and Impact
Previous speculation that the cause of a UK foodborne disease outbreak was soil from imperfectly cleaned vegetables is plausible. 相似文献4.
Background
Prostate cancer progression to androgen independence is the primary cause of mortality by this tumor type. The IGF-1/IGF-1R axis is well known to contribute to prostate cancer initiation, but its contribution to invasiveness and the downstream signalling mechanisms that are involved are unclear at present. 相似文献5.
Yuexing Zhang Yan Lu Hua Zhou Myounghee Lee Zhenqiu Liu Bret A Hassel Anne W Hamburger 《BMC cell biology》2008,9(1):69
Background
The ErbB3 binding protein-1 (Ebp1) belongs to a family of DNA/RNA binding proteins implicated in cell growth, apoptosis and differentiation. However, the physiological role of Ebp1 in the whole organism is not known. Therefore, we generated Ebp1-deficient mice carrying a gene trap insertion in intron 2 of the Ebp1 (pa2g4) gene. 相似文献6.
Michal Amir Shabtai Romano Shlomit Goldman Eliezer Shalev 《Reproductive biology and endocrinology : RB&E》2009,7(1):152-8
Background
To study the expression of Plexin-B1, Glycodelin, and MMP7 during the menstrual cycle in the endometrium and in the fallopian tube. 相似文献7.
Yu-Huei Liu Cheng-Hsu Chen Shih-Yin Chen Ying-Ju Lin Wen-Ling Liao Chang-Hai Tsai Lei Wan Fuu-Jen Tsai 《Journal of biomedical science》2010,17(1):81
Background
Idiopathic membranous nephropathy (IMN) is one of the most common forms of autoimmune nephritic syndrome in adults. The purpose of this study is to evaluate whether polymorphisms of PLA2R1 affect the development of IMN. 相似文献8.
Francesco Ria Romina Penitente Maria De Santis Chiara Nicolò Gabriele Di Sante Massimiliano Orsini Dario Arzani Andrea Fattorossi Alessandra Battaglia Gian Franco Ferraccioli 《Arthritis research & therapy》2008,10(6):R135
Introduction
Type II collagen is a DR4/DR1 restricted target of self-reactive T cells that sustain rheumatoid arthritis. The aim of the present study was to analyze the T-cell receptor repertoire at the onset of and at different phases in rheumatoid arthritis. 相似文献9.
Background
Cerebrotendinous xanthomatosis (CTX) is a rare lipid-storage disease. We investigated the clinic manifestation, histopathology and sterol 27-hydroxylase gene (CYP27A1) in a Chinese family with Cerebrotendinous Xanthomatosis (CTX). 相似文献10.
Background
Stromal derived factor (SDF-1), an alpha chemokine, is a widely known chemoattractant in the immune system. A growing body of evidence now suggests multiple regulatory roles for SDF-1 in the developing nervous system. 相似文献11.
A. Cadiere B. Couturaud J. Boismard P. Le Cann A. Gérard A. Mas C. Faye L. Garrelly B. Roig 《Journal of applied microbiology》2013,115(1):290-297
Aims
Virus detection has often been difficult due to a low concentration in water. In this study, we developed a new procedure based on concentration of virus particles on an innovative support: poly‐l ‐lysine dendrigrafts (DGL), coupled with directed nucleic acid extraction and real‐time PCR quantification.Methods and Results
This method was evaluated using the bacteriophage MS2 as a model virus. This virus exhibited the size and structural properties of human pathogenic enteric viruses and has often been used to assess new supports of concentration. Moreover, this bacteriophage is also a faecal contamination indicator. In this study, many water filtration conditions were tested (volume of water, concentration, etc.), and more than 80% of bacteriophage were recovered after filtration on polymer, in most conditions. We demonstrated that the method was linear (slope = 0·99 ± 0·04 and Y intercept when x = ?0·02 ± 0·28), valid (as manipulators, tested concentrations, volumes of sample and batch of polymer did not have any influence on concentration) and sensitive (allowing to concentrate up to 16 600‐fold 1 l of sample and to detect and quantify down to 750 GC l?1 and 7500 GC l?1, respectively).Conclusions
To conclude, this support exhibits high interest to retain viruses and to allow to detect low concentration of virus in water.Significance and Impact of the Study
This study gives valuable advance in the methods of concentration and diagnosis of virus in water. 相似文献12.
Wang Y Li D Xu N Tao W Zhu R Sun R Fan W Zhang P Dong T Yu L 《Arthritis research & therapy》2011,13(6):R193
Introduction
Follistatin-like protein 1 (FSTL1) is a secreted glycoprotein that has been implicated in arthritis pathogenesis in a mouse model. The aim of this study is to detect FSTL1 expression and to further assess its potential utility as a biomarker of joint damage in osteoarthritis (OA) patients. 相似文献13.
Zhang Z Kakutani K Maeno K Takada T Yurube T Doita M Kurosaka M Nishida K 《Arthritis research & therapy》2011,13(6):R200
Introduction
Intervertebral disc tissue homeostasis is modulated by a variety of molecules. Silent mating type information regulator 2 homolog 1 (SIRT1) plays a key role in various physiological processes. The aim of the present study was to verify the expression of SIRT1 and determine SIRT1 function in human intervertebral disc cell homeostasis. 相似文献14.
Makoto Sasaki Paul Jordan Tomas Welbourne Alireza Minagar Takashi Joh Makoto Itoh John W Elrod J Steven Alexander 《BMC physiology》2005,5(1):3
Background
Cytokine mediated induction of the mucosal addressin cell adhesion molecule-1(MAdCAM-1) expression is associated with the onset and progression of inflammatory bowel disease (IBD). 相似文献15.
Background
Cul1 is a core component of the evolutionarily conserved SCF-type ubiquitin ligases that target specific proteins for destruction. SCF action contributes to cell cycle progression but few of the key targets of its action have been identified. 相似文献16.
Anna Pistocchi Germano Gaudenzi Silvia Carra Erica Bresciani Luca Del Giacco Franco Cotelli 《BMC developmental biology》2008,8(1):27
Background
Prox1, the vertebrate homolog of prospero in Drosophila melanogaster, is a divergent homeogene that regulates cell proliferation, fate determination and differentiation during vertebrate embryonic development. 相似文献17.
Igor A Valouev Gleb V Fominov Elizaveta E Sokolova Vladimir N Smirnov Michael D Ter-Avanesyan 《BMC molecular biology》2009,10(1):60-13
Background
Termination of translation in eukaryotes is controlled by two interacting polypeptide chain release factors, eRF1 and eRF3. While eRF1 recognizes nonsense codons, eRF3 facilitates polypeptide chain release from the ribosome in a GTP-dependent manner. Besides termination, both release factors have essential, but poorly characterized functions outside of translation. 相似文献18.
Chun-Chou Tsai Bor-Show Tzang Szu-Yi Chiang Gwo-Jong Hsu Tsai-Ching Hsu 《Journal of biomedical science》2009,16(1):14-9
Background
Human parvovirus B19 infection has been postulated to the anti-phospholipid syndrome (APS) in autoimmunity. However, the influence of anti-B19-VP1u antibody in autoimmune diseases is still obscure. 相似文献19.
Maik?Grohmann Fabio?Spada Lothar?Schermelleh Natalia?Alenina Michael?Bader M?Cristina?Cardoso Heinrich?Leonhardt
Background
Mouse preimplantation development is characterized by both active and passive genomic demethylation. A short isoform of the prevalent maintenance DNA methyltransferase (Dnmt1S) is found in the cytoplasm of preimplantation embryos and transiently enters the nucleus only at the 8-cell stage. 相似文献20.
Hong Zhao Joy Innes David C Brooks Scott Reierstad Mehmet B Yilmaz Zhihong Lin Serdar E Bulun 《Reproductive biology and endocrinology : RB&E》2009,7(1):37