Hypotheses and causes of body height progressions since mid 19th century--a scientific historical review. I: Discussion of causes since the end of the 19th century to mid 20th century, including references on body height development in the 19th century

This examination is trying to give a scientific historical survey of the hypothesis and the reasons for progression of height since the middle of the 19th century. These progressions of height are not based on a single reason, but were kept going by the addition of consecutive reasons. Physical relief is mainly responsible for the most recent phase of progression of height.     

Sex and gender differences in secular trend of body size and frame indices of Lithuanians

In Lithuania, as in many other European countries, positive secular trend of body size became especially expressed at the middle of XX. century. The analysis showed the evident secular trend in height of adult Lithuanians since the end of XIX. century till 2001 from 163.5 till 181.3 cm in males and from 153.3 cm till 167.5 cm in females. Concerning growth and development of children, during the 1925-2001 period especially obvious acceleration of height was determined at the middle of adolescence due to much earlier sexual maturation at the end of XX. century. Secular trend of body height was more expressed in males of all ages, nevertheless this process stabilized in both sexes during the last decades. While comparing secular changes in BMI of adolescent Lithuanian girls and boys between the 1925-2001 period, the evident sexual differences in secular changes were determined from the middle of pubescence: the course of changes in BMI during the XX. century was nearly the same in both sexes, but at the end of XX. century older adolescent girls became obviously thinner compared with the changes of BMI in boys of the same age. A very similar trend in BMI of adult Lithuanian women since 1980 till 2002 was also detected. This phenomenon could be more related with the changes in life stile, modern-day canons for unrealistically thin female's body and strong social pressure on women today.     

Demographic analysis of the variation in the rates of multiple maternities in Sweden since 1751

To elucidate the causes and mechanisms of twinning and higher multifetal maternities, we have taken advantage of the statistical sources of Sweden, where continuous statistics for the whole population are the oldest available. We found strong secular and regional fluctuations. The rates of multiple maternities were the highest during the last three decades of the 18th century, when the twinning rate was more than 17 per 1,000, the triplet rate was more than 3 per 10,000, and the quadruplet rate was almost 7 per 1 million maternities. During 1849-1873 the twinning rate in Sweden was 14.2 per 1,000, but this rate showed great regional differences, being 18.0 per 1,000 on the island of Gotland and 12.6 per 1,000 in the county of Alvsborg. During this period the twinning rate in the countryside in the county of Stockholm was 20.4, but in the city of Stockholm it was only 14.1 per 1,000. In Sweden after the 1930s there was a marked decrease in the twinning rate, which by the 1960s had fallen to only about half of what it had been two centuries earlier. The corresponding reductions for triplet and quadruplet rates were about 75%. The aim of this paper was to study the temporal and regional variations in multiple maternities in Sweden from 1751 to 1960 based on demographic and some socioeconomic data for the counties. We confirmed our earlier studies that maternal age and parity cannot satisfactorily explain the secular and regional differences in the twinning rates. In contrast to studies in France (1901-1968), we found no unequivocal association between the twinning rates and the crude birth rates. The correlation coefficients between the twinning rate and the crude birth rate showed statistically significant regional and temporal variations. After eliminating the temporal trends, regional differences in the correlation coefficients remained. The twinning rates for the counties seem to converge toward a common low level, 10-12 per 1,000. The observed convergence toward relatively similar levels may be caused by the increased matrimonial migration distances and decreased endogamy of the citizens as a consequence of better communications. The increased urbanization and industrialization that started in the last decades of the 19th century broke up the old static agrarian isolates and caused Sweden, within 2-3 generations, to develop from a poor nation to one of the most prosperous in the world. A more urban and affluent lifestyle, a better diet, and increased stress and sedentary occupations may have reduced the physical capacity of mothers to carry gestations with multiple embryos or fetuses to completion.     

Climate implications of biomass burning since the 19th century in eastern North America

Recent predictions that tropospheric aerosols have counterbalanced greenhouse warming assume aerosol emissions were low before ad 1850 and then increased dramatically with industrialization of the Northern Hemisphere and biomass burning in the Tropics. We assembled the lake sediment record of emissions across northeastern North America, where temperatures are predicted to have been substantially affected by industrial aerosols. Sediment evidence suggests a systematic shift in source and an overall decline in emissions since the 19th century. The geographical shift results from high presettlement emissions from wildfires in the Midwest that collapsed with tillage and fire suppression. Meanwhile, emissions were increasing in the North-east with European settlement. These regional changes produced a shift from the continental interior to the North-east. An overall decline results because decreases in the Midwest more than compensate for increases in the North-east. Results suggest the Central Plains as an important source of emissions in the recent past, consistent with pioneer accounts of dense smoke clouds emanating from prairie in the 19th century. Contrary to recent models that suggest increased 20th century combustion emissions could have offset warming effects of rising greenhouse gases, our data suggest that aerosols could have actually decreased over this interval. Although we cannot directly quantify aerosols from our methods, the emissions of large particles suggest assumptions of 20th century aerosol declines should be reconsidered.     

Average body height of the middle and lower social classes in the middle European Germanic settlement area from the early Middle Ages to modern times

This paper reviews the body height data of middle and low social classes of North and Central European populations from the early Middle Ages until the beginning of the 17th century. It is mainly based on anthropological data from the ancient Germans, but considers also some historical reports. From the data presented here it is seen that the initially rather considerable body heights in these two social groups are decreasing during the Middle Ages. This could be observed on population samples from the Central German Highlands and from Southern Germany as well as on samples from the utmost Western Teutonic settlement: Greenland. The reasons for these variations are most likely to be seen in nutritional changes, in increasing hard physical work due to the transition to predominating agriculture, in biological effects of birthrights, and in deteriorating hygienic conditions.     

Impacts of climate change on natural forest productivity – evidence since the middle of the 20th century

Changes to forest production drivers (light, water, temperature, and site nutrient) over the last 55 years have been documented in peer‐reviewed literature. The main objective of this paper is to review documented evidence of the impacts of climate change trends on forest productivity since the middle of the 20th century. We first present a concise overview of the climate controls of forest production, provide evidence of how the main controls have changed in the last 55 years, followed by a core section outlining our findings of observed and documented impacts on forest productivity and a brief discussion of the complications of interpreting trends in net primary production (NPP). At finer spatial scales, a trend is difficult to decipher, but globally, based on both satellite and ground‐based data, climatic changes seemed to have a generally positive impact on forest productivity when water was not limiting. Of the 49 papers reporting forest production levels we reviewed, 37 showed a positive growth trend, five a negative trend, three reported both a positive and a negative trend for different time periods, one reported a positive and no trend for different geographic areas, and two reported no trend. Forests occupy ≈52% of the Earth's land surface and tend to occupy more temperature and radiation‐limited environments. Less than 7% of forests are in strongly water‐limited systems. The combined and interacting effects of temperature, radiation, and precipitation changes with the positive effect of CO₂, the negative effects of O₃ and other pollutants, and the presently positive effects of N will not be elucidated with experimental manipulation of one or a few factors at a time. Assessments of the greening of the biosphere depend on both accurate measurements of rates (net ecosystem exchange, NPP), how much is stored at the ecosystem level (net ecosystem production) and quantification of disturbances rates on final net biome production.     

Secular trend in age at menarche in China: a case study of two rural counties in Anhui Province.

There is increasing evidence that age at menarche has decreased in Europe and the United States during the last century and in Japan over the last several decades. Data from a community-based survey conducted in two rural counties of Anhui Province in China indicate a similar, downward secular trend in age at menarche for Chinese women. The present study shows the mean age at menarche decreased by 2.8 years, from 16.5 to 13.7, over an approximate 40-year time interval. This rapid decrease in age at menarche may partly be due to better nutrition and living standards reflected by the improved socioeconomic standards experienced in China over the past few decades. To test this hypothesis, a number of determinants of age at menarche were assessed; year of birth, literacy status, county of residence, amount of physical labour, general health status, pesticide exposure before age at menarche, and drinking water source were all found to be associated with age at menarche.     

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

The transforming protein of polyoma virus, middle T antigen, associates with the protein tyrosine kinase pp60c-src, and analysis of mutants of middle T suggests that this complex plays an important role in transformation by polyoma. It has recently been reported that pp60c-src from polyoma virus-transformed cells has enhanced tyrosine kinase activity in vitro. The data presented here confirm these findings and show that the enhanced kinase activity of pp60c-src is due to an increase in the Vmax of the enzyme. Sucrose density gradient analysis demonstrates that only the form of pp60c-src which is bound to middle T antigen is activated. The difference in enzyme activity between pp60c-src from normal and middle T-transformed cells is more marked when the enzyme is prepared from lysates containing the phosphotyrosine protein phosphatase inhibitor, sodium orthovanadate. pp60c-src from middle T transformed cells is unaffected, but pp60c-src from normal cells has reduced kinase activity if dephosphorylation is prevented. The kinase activity of pp60c-src thus appears to be regulated by its degree of phosphorylation at tyrosine, and data are presented which support this hypothesis. pp60c-src is the first example of a protein tyrosine kinase whose activity is inhibited by phosphorylation at tyrosine. Middle T antigen may increase the kinase activity of pp60c-src by preventing phosphorylation at this regulatory site.     

A cephalometric comparison of skulls from different time periods--the Bronze Age, the 19th century and the present

The aim of this study was to evaluate secular trends by means of orthodontic measurements on lateral cephalograms. We use roentgenograms from three populations: 22 Bronze Age skulls from a cemetery near Hainburg/Austria, 140 soldiers who served in the Hapsburg Imperial Army in the late 19th century, and 154 contemporary recruits of the Austrian Federal Army. Using conventional morphometric analysis, no statistically significant differences could be established. But applying geometric morphometrics to the 2D-coordinates of the pentagon composed of the landmarks Sella, Nasion, Articulare, Gonion and Menton, some biologically interpretable differences were detected, the size allometry between the 19th- and 20th-century populations being the only notable one. We conclude that landmarks should be digitized directly (and many more of them) and that conventional methods used in clinical orthodontics are inappropriate for addressing the scientific questions approached here.     

Secular change in long bone length and proportion in the United States, 1800-1970.

We examine secular change in long bone lengths and allometry of Americans dating from the mid-19th century to the 1970s. Skeletal samples were derived from the Huntington Collection, Terry Collection, World War II casualties, and the Forensic Anthropology Data Bank. Regression of bone length on year of birth allowed evaluation of the secular change in bone length. Size was computed as the geometric mean of all bone lengths, and shape as the ratio of each bone to size. These variables were then regressed on year of birth, allowing evaluation of allometric secular change. The results revealed a pattern of change that can be summarized as follows: male secular change is stronger than female, lower limb bone secular change is more pronounced than upper limb bone change, and distal bones change more than proximal bones, particularly in the lower limb. In males, white changes are uniformly higher than black but these differences do not rise to the level of statistical significance. Environmental forces, such as nutrition and disease, are the usual causes of secular changes in overall size. This paper shows that long bone proportions also respond to these same environmental factors. Moreover, the changes in body proportion are likely to be due to allometric consequences of growth changes that occur early in life. Am J Phys Anthropol 110:57-67, 1999.     

Homemakers and heights. Intra-household resource allocation and male stature in the Netherlands, 1860–1930

In this article we test the hypothesis that the secular increase in heights in the course of the second half of the nineteenth century was associated with the rise of the breadwinner-homemaker household. In these ‘modern’ households, women raised the living standards (quality and quantity of food, hygiene and care) for all members, especially the children. We model the assumed contributions to the family budget by age and gender of household members, and find that a strong imbalance between consumers and producers in the household put severe strains on effective resource allocation, leading to lower net nutrition and lower young adult heights. We suggest a carefully calibrated consumer/producer ratio as an indicator to capture these effects. The ratio is not meant to replace others, and we show that sibling rank order as well as gender preferences also played a role in intra-household resource allocation. For our research, we have used a database with reconstructed life histories (including co-residence) of 3003 Dutch army recruits. Our results indicate that the consumer/producer ratio as experienced by recruits in their early life indeed had a strong impact (-1,8 cm) on their heights. However, this effect differed by social class, which can be explained by differences in acceptance of the income pooling model.     

Climatic response of Chinese pine and PDSI variability in the middle Taihang Mountains, north China since 1873

We reconstructed the first Palmer Drought Severity Index (PDSI) in the Taihang Mountains, north China from 1873 to 2008, based on ring width of the Chinese Pine (Pinus tabulaeformis Carr). The reconstruction can explain 43.2 % of the PDSI from instrument record during the calibration period (1955–2005). The PDSI variability was relatively stable before the twentieth century. However, it became more variable and persistent during the twentieth and early twenty-first century. Persistent long dry intervals were found in 1920–1931, 1973–1982 and 1992–2001, and the wet intervals were identified in 1944–1965 and 2004–2008. Comparing with the 1920s, the dryness of the 1970s and 1990s were more intense and the 1990s ranked the most severe drought for the whole reconstructed period in the Taihang Mountains. After a decreasing trend since the 1950s, the PDSI shows increasing tendency after 2000, demonstrating a better moisture condition in recent years in the studied area. Comparisons of our reconstruction with nearby dry/wet index and other tree-ring-based PDSI reconstruction showed high consistency in dry (wet) periods, showing similar dry–wet regimes around the sampled site, which was also further proved by the spatial correlation analysis. This reconstruction is also highly correlated with the East Asian Summer Monsoon (EASM) index, suggesting the reconstructed PDSI could be used to indicate the strength of EASM. Spectral analysis revealed significant peaks at 2.05, 2.07, 2.65, 3.75, 10 and 60 years, implying the influence of larger circulation system (such as ENSO, PDO and NAO) and solar activity on local climate.     

Significance of the gastrin homology and surrounding sequences in polyomavirus middle T antigen for cell transformation.

Deletion of residues 305 to 327 of polyomavirus middle T antigen, including the (Glu)6-Tyr-315 sequence that is a preferred site of phosphorylation in vitro by pp60c-src, markedly altered viral transformation of rat cells. The efficiency of transformation by the deletion mutant depended on how it was introduced into cells, and the resulting transformants displayed limited growth rates in monolayer and in suspension. Substitution of the polyomavirus residues 305 to 327 with a homologous region (containing [Glu]5-Ala-Tyr) from porcine gastrin did not restore wild-type transforming activity. These mutant middle T antigens interacted with pp60c-src and were phosphorylated in vitro. Thus, although a sequence of consecutive glutamic acid residues followed by a tyrosine is a dominant structural element which strongly influences the physical properties of middle T antigen, its presence did not ensure the biological activity of the protein. Other elements in this region of middle T antigen also contributed substantially to the transforming capacity of polyomavirus.     

Genetic therapy, identity and the person-regarding reasons

It has been argued that there can be no person-regarding reasons for practising genetic therapy, since it affects identity and causes to exist an individual who would not otherwise have existed. And there can be no such reasons for causing somebody to exist because existing cannot be better for an individual than never existing. In the present paper, both of these claims are denied. It is contended, first, that in practically all significant cases genetic therapy will not affect the identity of beings of our kind. This is so irrespective of whether, essentially, we are beings with minds or beings of a certain biological species, the human one. Second, it is contended that, even if genetic therapy were to affect our identity, there could be person-regarding reasons for conducting it, for existence can be better than non-existence for the individual.     

Growth variation, final height and secular trend. Proceedings of the 17th Aschauer Soiree, 7th November 2009

Growth and body height have always been topics interesting to the public. In particular, the stupendous increase of some 15-19 cm in final adult height during the last 150 years in most European countries (the “secular trend”), the concomitant changes in body and head proportions, the tendency towards early onset of sexual maturation, the changes in the age when final height is being reached, and the very recent trend in body mass index, have generated much scientific literature. The marked plasticity of growth in height and weight over time causes problems. Child growth references differ between nations, they tend to quickly become out of date, and raise a number of questions regarding fitting methods, effects caused by selective drop-out, etc. New findings contradict common beliefs about the primary importance of nutritional and health related factors for secular changes in growth. There appears to be a broad age span from mid-childhood to early adolescence that is characterised by a peculiar insusceptibility. Environmental factors that are known to influence growth during this age span appear to have only little or no impact on final height. Major re-arrangements in height occur at an age when puberty has almost been completed and final height has almost been reached, implying that factors, which drive the secular trend in height, are limited to early childhood and late adolescence.     

Preliminary studies of an interdisciplinary inquiry of the body height proportions of Germans in the 19th century and of the influence of living conditions. II. Original preliminary studies for Baden, Alsace-Lorraine, Bavaria, the whole German Reich, summarizing evaluation, historical nutritional references, literature

In Part I of this examinations, preliminary original researches about the constitutional situations in Germany from the North to the kingdom Württemberg has been presented. In this part II, such preliminary researches follow for the other southern part of the German settlement. With references to Baden, Alsace-Lorraine, and Bavaria first since the second part of the 19th century, comprehensive anthropological data exist, but these contain valuable and differentiated data material. A first analysis for this German data material does not reveal regular relation-ships between body-height, urban and rural life, and geographical altitude. But there are relation-ships between wealthy and poor social classes and between educated and heavily working people, and there exists a negative trend in the body-height-means from the North and South to the middle of the German settlement with minima in Saxony and in several regions in Southern Germany. As spread for the different means about 160 to more than 170 cm is to estimate. The spread seems to be broader in the second half of the 19th century, presumably because the better life-conditions does not hold for all Germans in the same manner. About of the beginning of the 20th century, the body-height-means show an increase with may by interpreted as an kind of rehabilitation after times of emergency in the early industrialization and of difficulties in food supply.     

Genetic therapy, person-regarding reasons and the determination of identity -- a reply to Robert Elliot

I have outlined two ways of defending the claim that there are so-called person-regarding reasons for practising gene therapy on human conceptuses. One is metaphysical and concerns our nature and identity. The upshot of it is that, in cases of most interest, this therapy does not affect our identity, by bringing into existence anyone of our kind who would not otherwise have existed. The other defence is value theoretical and claims that even if genetic therapy were to affect the identity of beings our kind, there could still be person-regarding reasons for performing it, since we can be benefited and harmed by being caused to exist or not to exist. Robert Elliot has attacked both of these lines, and my present objective is to show how his criticisms can be deflected.     

Evidence that the middle T antigen of polyomavirus interacts with the membrane skeleton.

The transforming protein of polyomavirus, middle T antigen, is associated with cellular membranes. We have examined the subcellular location of the middle T antigen in two different cell types by fractionation and detergent phase partitioning. Middle T antigen expressed in human cells by a recombinant adenovirus was detected primarily in the membrane skeleton. Sucrose gradient fractionation revealed that the middle T antigen was associated with complexes with molecular weights of 500,000 to 1,000,000. Several markers for cytoskeleton cofractionate with these complexes, including actin, tubulin, and vimentin. Electron micrographs of membrane skeleton prepared from cells expressing middle T antigen demonstrated that this material contained primarily fibrous structures and was clearly devoid of bilayer membranes. These structures were distinct from the filamentous structures observed in fractions enriched for cytoskeleton. Consistent with a role for membrane skeleton localization in transformation, middle T antigen was detected exclusively in fractions enriched for membrane skeleton in middle T antigen-transformed Rat-2 cells. Our results may resolve the apparent difference between middle T antigen localization as determined by immunomicroscopy and that determined by subcellular fractionation.