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Hypoxia up-regulates hypoxia-inducible factor-1alpha transcription by involving phosphatidylinositol 3-kinase and nuclear factor kappaB in pulmonary artery smooth muscle cells 总被引:7,自引:0,他引:7
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Belaiba RS Bonello S Zähringer C Schmidt S Hess J Kietzmann T Görlach A 《Molecular biology of the cell》2007,18(12):4691-4697
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Role of ERK and calcium in the hypoxia-induced activation of HIF-1 总被引:17,自引:0,他引:17
Mottet D Michel G Renard P Ninane N Raes M Michiels C 《Journal of cellular physiology》2003,194(1):30-44
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Hsp90 regulates a von Hippel Lindau-independent hypoxia-inducible factor-1 alpha-degradative pathway 总被引:19,自引:0,他引:19
Isaacs JS Jung YJ Mimnaugh EG Martinez A Cuttitta F Neckers LM 《The Journal of biological chemistry》2002,277(33):29936-29944
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Thioredoxin 1 and thioredoxin 2 have opposed regulatory functions on hypoxia-inducible factor-1alpha
Zhou J Damdimopoulos AE Spyrou G Brüne B 《The Journal of biological chemistry》2007,282(10):7482-7490
Hypoxia inducible factor 1 (HIF-1), a key regulator for adaptation to hypoxia, is composed of HIF-1alpha and HIF-1beta. In this study, we present evidence that overexpression of mitochondria-located thioredoxin 2 (Trx2) attenuated hypoxia-evoked HIF-1alpha accumulation, whereas cytosolic thioredoxin 1 (Trx1) enhanced HIF-1alpha protein amount. Transactivation of HIF-1 is decreased by overexpression of Trx2 but stimulated by Trx1. Inhibition of proteasomal degradation of HIF-1alpha in Trx2-overexpressing cells did not fully restore HIF-1alpha protein levels, while HIF-1alpha accumulation was enhanced in Trx1-overexpressing cells. Reporter assays showed that cap-dependent translation is increased by Trx1 and decreased by Trx2, whereas HIF-1alpha mRNA levels remained unaltered. These data suggest that thioredoxins affect the synthesis of HIF-1alpha. Trx1 facilitated synthesis of HIF-1alpha by activating Akt, p70S6K, and eIF-4E, known to control cap-dependent translation. In contrast, Trx2 attenuated activities of Akt, p70S6K, and eIF-4E and provoked an increase in mitochondrial reactive oxygen species production. MitoQ, a mitochondria specific antioxidant, reversed HIF-1alpha accumulation as well as Akt activation under hypoxia in Trx2 cells, supporting the notion of translation control mechanisms in affecting HIF-1alpha protein accumulation. 相似文献
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Niu G Briggs J Deng J Ma Y Lee H Kortylewski M Kujawski M Kay H Cress WD Jove R Yu H 《Molecular cancer research : MCR》2008,6(7):1099-1105
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