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54 patients affected with acute lymphatic leukaemia (ALL) in the period from 1978-1984 were examined concerning the frequency of pre-B-ALL in comparison with other immunological subtypes of ALL. For this purpose the following markers were tested: 1. Cytoplasmatic IgM 2. Rosette formation with sheep erythrocytes 3. T-cell specific antigen 4. C-ALL antigen 5. Surface immunoglobulin By means of these markers the patients were divided into 5 immunological subtypes of ALL, viz. 1. Pre-B-ALL (16.6%) 2. O-ALL (37.1%) 3. C-ALL (27.9%) 4. T-ALL (16.6%) 5. B-ALL (1.8%) The immunological subtypes of ALL were compared by means of clinical parameters (age, initial leukocyte number, mediastinal tumor, initial CNS involvement). No difference could be detected between O-ALL, pre-B-ALL and C-ALL, whereas T-ALL showed a distinctly worse prognosis. 相似文献
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Gowri M Jahan SK Kavitha Prasannakumari Madhumathi Appaji L 《Indian journal of human genetics》2011,17(3):235-237
Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML). 相似文献
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目的:探究格列卫治疗相关毒副反应,总结相关毒副反应的临床表现、实验室特征.提高临床医生对于格列卫相关毒副反应的认识和处理水平.方法:分析1例接受格列卫治疗的慢性粒细胞白血病并骨髓纤维化患者自行停药后出现致死性骨髓坏死的临床表现特征,实验室检查,治疗过程及预后情况.结果:该例慢性粒细胞白血病并骨髓纤维化患者对羟基脲、干扰素和常规HA方案化疗不敏感.患者接受格列卫治疗1月后临床症状、血象明显改善.格列卫治疗2月后出现背痛,下肢疼痛副反应.格列卫不当停药后出现致死性骨髓坏死.结论:格列卫对于慢性粒细胞白血病合并骨髓纤维化患者的疗效尤其优于羟基脲、干扰素和常规化疗.接受格列卫治疗的患者当出现药物副反应考虑停药时应慎重. 相似文献
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A case of therapy-related leukemia is described. Other cases of acute nonlymphocytic leukemia have been associated with the intramuscular administration of thiotepa (an alkylating agent), but this patient received only intravesical instillations of the drug. The interval between the start of chemotherapy and the onset of leukemia was 56 months. 相似文献
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Acute lymphoblastic leukemia with hand-mirror cells (ALL-HMC) was diagnosed in a 20-year old patient. Cytochemical investigations revealed a positive reaction for PAS and acid phosphatase. Lymphoid blast cells were studied with various monoclonal antibodies in order to determine their derivation and differentiation. The data obtained (positivity for Leu 9, OKT 11 and OKT 8) suggest that blast cells were of T lineage with OKT 8 phenotype. This report supports the phenotypic heterogeneity of ALL-HMC. 相似文献
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A Ohsaka Y Miura A Takahashi T Yokoyama 《Virchows Archiv. B, Cell pathology including molecular pathology》1991,60(6):399-405
A morphometric analysis of bone marrow biopsy specimens from patients with myelofibrosis was made to determine the amount of lattice fiber and the number of megakaryocytes, to compare the degree of myelofibrosis in primary and secondary myelofibrosis, and to assess the relationship between the morphometric findings and other parameters. Eight patients with agnogenic myeloid metaplasia (AMM) and six with chronic myelogenous leukemia associated with frank myelofibrosis (CML-MF) were studied. When the main clinical, hematological, and laboratory features of both groups of patients were compared, the only significant difference was in the neutrophil alkaline phosphatase score. Morphometric study showed that the amount of lattice fiber and the number of megakaryocytes in AMM were not statistically different from those in CML-MF, and that neither the number of megakaryocytes nor the platelet count correlated with the amount of lattice fiber. 相似文献
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M. Hussein Khan 《Human genetics》1973,18(1):55-62
Summary Serial cytogenetic studies of bone marrow in a 59-year-old male with a 14-month history of acute myeloid leukemia revealed a Ph1 disomic diploid clone (46, XY, 2Ph1). This clone responded to a cytostatic drug regimen of prednisone, vincristine and daunomycine. A dual population of normal and leukemic cells was observed during the course the disease.
Supported by the Deutsche Forschungsgemeinschaft, Bad Godesberg.
Presented in part at the thirteenth International Congress of Hematology Munich 1970.
Dedicated to Prof. Dr. Sajiro Makino, Faculty of Science, Hokkaido University, Sapporo, Japan. 相似文献
Zusammenfassung Bei einem 59 Jahre alten Mann mit akuter Myeloblastenleukämie, von 14monatigem Verlauf, fand sich im Knochenmark ein Doppel-Ph1 diploider Clone (46, XY, 2Ph1). Dieser Clone war empfindlich gegenüber einer Prednison-, Vincristin- und Daunomycin-Kombination. Eine Dualpopulation normaler und leukämischer Zellen wurde während des Verlaufes beobachtet.
Supported by the Deutsche Forschungsgemeinschaft, Bad Godesberg.
Presented in part at the thirteenth International Congress of Hematology Munich 1970.
Dedicated to Prof. Dr. Sajiro Makino, Faculty of Science, Hokkaido University, Sapporo, Japan. 相似文献