KF-3000脑循环分析仪

KF-3000脑循环分析仪是上海匡复医疗设备发展有限公司和复旦大学联合研究基础上开发的新一代的脑循环动力学检测与分析仪器。它通过无创检测颈动脉的血流速度、血液压力、血管管径和人体血压,以及颅内大脑两侧前、中、后动脉及椎动脉的血流速度．运用脑循环动力学模型和专用计算软件来计算分析反映脑循环功能状况的脑血管动力学参数。     

KF-3000脑循环分析仪

KF-3000脑循环分析仪是上海匡复医疗设备发展有限公司和复旦大学联合研究基础上开发的新一代的脑循环动力学检测与分析仪器。它通过无创检测颈动脉的血流速度、血液压力、血管管径和人体血压,以及颅内大脑两侧前、中、后动脉及椎动脉的血流速度,运用脑循环动力学模型和专用计算软件来计算分析反映脑循环功能状况的脑血管动力学参数。     

KF-3000脑循环分析仪

KF-3000脑循环分析仪是上海匡复医疗设备发展有限公司和复旦大学联合研究基础上开发的新一代的脑循环动力学检测与分析仪器。它通过无创检测颈动脉的血流速度、血液压力、血管管径和人体血压,以及颅内大脑两侧前、中、后动脉及椎动脉的血流速度,运用脑循环动力学模型和专用计算软件来计算分析反映脑循环功能状况的脑血管动力学参数。     

KF-3000脑循环分析仪

KF-3000脑循环分析仪是上海匡复医疗设备发展有限公司和复旦大学联合研究基础上开发的新一代的脑循环动力学检测与分析仪器。它通过无创检测颈动脉的血流速度、血液压力、血管管径和人体血压,以及颅内大脑两侧前、中、后动脉及椎动脉的血流速度,运用脑循环动力学模型和专用计算软件来计算分析反映脑循环功能状况的脑血管动力学参数。     

脑Willis环循环分析专用软件研制Ⅰ．软件功能介绍

脑血管疾病是严重危害人类健康的常见病。大量实验及临床研究表明．许多患者在发病前期．其循环动力学状态已有显著变化,因此为了适应于临床检测和大规模人群普查,有必要编制一套基于Win95／Win98平台上的专用软件,用于实时检测与分析脑血管动力学参数,使它成为早期诊断有价值的指标。本文描述了该软件的流程和各模块的功能,有关临床实际应用将在后续文章中叙述。     

超声大脑中动脉血流参数对脑小血管疾病患者脑白质病变程度的评估价值研究

摘要 目的：分析超声大脑中动脉血流参数对脑小血管疾病（CSVD）患者脑白质病变（WLMs）程度的评估价值。方法：选取2021年1月至2024年1月期间延安大学附属医院收治的98例CSVD患者为研究组,另选取同期60例体检健康者为对照组,按照WLMs严重程度分为轻度组（n=42）、中度组（n=36）及重度组（n=20）,通过超声检查收集受试者超声大脑中动脉收缩期峰值血流速度（Vs）、舒张期峰值血流速度（Vd）、平均血流速度（Vm）、搏动指数（PI）及屏气指数（BHI）,对比研究组与对照组、不同WLMs严重程度的大脑中动脉血流参数。结果：研究组Vs、Vd、Vm及BHI均低于对照组,PI较对照组更高（P<0.05）。3组患者大脑中动脉血流参数对比存在显著差异（P<0.05）;与轻度组对比,中、重度组Vs、Vd、Vm及BHI均下降,PI升高（P<0.05）;重度组Vs、Vd、Vm及BHI均低于中度组,PI高于中度组（P<0.05）。结论：超声大脑中动脉血流参数与CSVD患者WLMs严重程度呈显著相关,可作为早期评估WLMs严重程度的无创指标。     

一种评价脑循环动力学综合功能的新方法

目的通过对与脑循环功能相关的12个血液动力学参数进行分析,得出能够反映脑循环总体功能的一个综合指标。方法采用病例对照方法,获得120例脑血管疾病患者和130例正常者对照的流行病学资料,年龄在20岁至70岁。综合应用主成分分析、logistic回归分析等方法得到四种综合指标计算模型,并将这四种模型在临床上通过ROC曲线进行初步检验评价。结果在对原始计算数据250例人群的检验中,四个综合指标的ROC曲线下面积分别为0．905、0．901、0．942、0．911。在临床上对另外的年龄为20岁至70岁的775例人群的检验中,四个综合指标的ROC曲线下面积分别为0．943、0．940、0．969和0．945;在对年龄为50岁至60岁的144例人群的检验中,四个综合指标的ROC曲线下面积分别为0．866、0．862、0．935和0．847。讨论对12个参数进行主成分回归后选取前三个主成分进行logistic回归分析后得到的评价模型作为反应脑循环总体功能的综合指标具有较佳的评价能力与更好的稳定性。     

脑循环功能检测技术近三十年进展

脑循环功能的异常改变往往早于形态学和影像学改变,这对于脑血管的早期检测以及治疗过程中疗效的评价有显著意义。国内外脑循环功能检测技术的发展已有30年左右的历史,本文综述了脑循环动力学参数的生理背景及脑循环功能检测技术近年来的发展。     

脑循环功能治疗仪的作用机理及临床效果

介绍了脑血管疾病严重危害人类健康,脑循环功能治疗仪通过交变电磁场刺激颅脑、仿真生物电刺激小癌顶核和患肢肌肉神经来达到治疗目的,取得了较好的效果。     

Cerebral venous hemodynamics and the basicranium of Cebus

The study of basicranial foramina has played an important role in primatological investigations. They are often the only clues for deciphering cerebral vascular evolution in fossil forms. This study illustrates the significance of considering foraminal shape when analyzing or describing basicranial anatomy in living and fossil primates. It is suggested that certain hemodynamic properties of cerebral venous drainage in Cebus represent patterns that were most likely present in ancestral catarrhines.     

嵌入式AFP测试仪的设计

介绍了一个嵌入式AFP测试仪的设计。测试仪以嵌入式微处理器LPC2210为核心,主要包括数据采集、步进电机的驱动及人机交互界面等几部分。测试仪可通过RS232与PC机通讯,进行数据处理及报告分析,具有一定的临床辅助诊断价值。     

脑血管病继发癫痫66例临床研究

目的:探讨脑血管病与继发性癫痫的关系。方法:对66例脑血管病继发性癫痫作总结分析。结果:早期型癫痫43例,迟发型癫痫23例。病变部位多侵及脑叶(47/66),癫痫以全面发作居多,治疗效果佳。结论:脑血管病是继发性癫痫的重要原因之一,早期型癫痫多不需长期服抗癫痫药,迟发型癫痫多需长期服抗癫痫药,脑血管病急性期癫痫发作组患者死亡率明显高于非癫痫组,癫痫持续状态提示患者病情危重、预后不良。     

Fate of Cerebrospinal Fluid-Borne Amyloid β-Peptide: Rapid Clearance into Blood and Appreciable Accumulation by Cerebral Arteries

Abstract: In Alzheimer's disease, the neuritic or senile amyloid plaques in hippocampus and association cortex, the diffuse plaques in brain areas such as the cerebellum and sensorimotor cortex, and the amyloid deposits in the walls of pial and parenchymal blood vessels are mainly composed of amyloid β-peptides. In the present study, either soluble 40-residue amyloid β-peptide radiolabeled with ¹²⁵I (I-sAβ) or [¹⁴C]polyethylene glycol ([¹⁴C]-PEG, a reference material) was briefly infused into one lateral ventricle of normal rats. By 3.5 min, 30% of the I-sAβ was cleared from ventricular CSF into blood; another 30% was removed over the next 6.5 min. No [¹⁴C]PEG was lost from the CSF-brain system during the first 5 min, and only 20% was cleared by 10 min. Much of the I-sAβ that reached the subarachnoid space was retained by pial arteries and arterioles. Virtually no I-sAβ was found in brain. The clearance of amyloid β-peptides from the CSF-brain system, reported herein for normal rats, may be reduced in Alzheimer's disease, thus contributing to amyloid deposition in cerebral tissue and blood vessels.     

Isoform-Specific Effects of Apolipoproteins E2, E3, and E4 on Cerebral Capillary Sequestration and Blood-Brain Barrier Transport of Circulating Alzheimer's Amyloid β

Abstract: Cerebral capillary sequestration and blood-brain barrier (BBB) permeability to apolipoproteins E2 (apoE2), E3 (apoE3), and E4 (apoE4) and to their complexes with sAβ_1–40, a peptide homologous to the major form of soluble Alzheimer's amyloid β, were studied in perfused guinea pig brain. Cerebrovascular uptake of three apoE isoforms was low, their blood-to-brain transport undetectable, but uptake by the choroid plexus significant. Binding of all three isoforms to sAβ_1–40 in vitro was similar with a K _D between 11.8 and 12.9 n M . Transport into brain parenchyma and sequestration by BBB and choroid plexus were negligible for sAβ_1–40-apoE2 and sAβ_1–40-apoE3, but significant for sAβ_1–40-apoE4. After 10 min, 85% of sAβ_1–40-apoE4 taken up at the BBB remained as intact complex, whereas free sAβ_1–40 was 51% degraded. Circulating apoE isoforms have contrasting effects on cerebral capillary uptake of and BBB permeability of sAβ. ApoE2 and apoE3 completely prevent cerebral capillary sequestration and blood-to-brain transport of sAβ_1–40. Conversely, apoE4, by entering brain microvessels and parenchyma as a stable complex with sAβ, reduces peptide degradation and may predispose to cerebrovascular and possibly enhance parenchymal amyloid formation under pathological conditions.     

Circadian Variation in the Onset of Acute Cerebral Ischemia: Ethiopathogenetic Correlates in 80 Patients Given Angiography

In a continuous series of 80 acute ischemic hemispheric strokes, the onset of symptoms was between 6:01 a.m. and noon in 45% of cases, between noon and 6:00 p.m. in 22.5%, between 6:Ol p.m. and midnight in 31.25%, and between midnight and 6:00 a.m. in 1.25% (p < 0.0001). By means ofangiography and computerized tomography, and by detection of arterial and cardiac sources of emboli, four stroke subtypes were identified. Embolic and thrombotic strokes had their most frequent onset between 6:01 a.m. and noon (45% and 71%, respectively), whereas strokes of unknown origin and lacunar strokes were randomly distributed between 6:01 p.m. and midnight. The morning activation of the catecholaminergic system can account for this pattern of circadian onset of ischemic stroke.     

脑血管病的康复治疗疗效观察

目的：探讨早期康复治疗在脑血管病康复中的应用及疗效观察早期康复治疗对脑血管病患者功能重建是否有效,是否值得推广。方法：选取本院神经科2009年6月至2010年3月住院40例脑血管病患者,随机分为康复治疗组和对照组（每组20例）,康复治疗组在进行常规治疗的同时,进行早期康复训练,并且在康复治疗前后分别进行Barthel指数（ADL）评分,以量化分析治疗前后的效果。结果：经康复训练后,康复治疗组治疗前与治疗后比较,ADL评分有明显的增高,二者的差异具有显著性（P〈0．01）;康复治疗组与对照组在神经功能恢复方面,有明显的好转,二者的差异具有显著性（P〈0．01）。结论：脑血管病患者早期进行常规治疗,同时行康复训练治疗,有助于神经功能的恢复,提高自理能力及生活质量,此治疗方案对脑血管患者的康复有积极的作用,疗效满意,方法值得在康复相关科室长期应用推广。     

降纤酶对急性脑梗死患者凝血指标的影响

目的 对４０例急性脑梗死患者应用降纤酶治疗,监测治疗前后凝血指标变化。方法 采用美国库尔特公司２００型血凝仪检测凝血指标。结果 降纤酶可以显著降低纤维蛋白原（Ｐ〈０．０５）,对其它凝血指标有影响,但无统计学意义（Ｐ〉０．０５）。结论 降低纤维蛋白原是降纤酶的显著特征。