共查询到20条相似文献,搜索用时 31 毫秒
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TEL, a putative tumor suppressor, modulates cell growth and cell morphology of ras-transformed cells while repressing the transcription of stromelysin-1
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Fenrick R Wang L Nip J Amann JM Rooney RJ Walker-Daniels J Crawford HC Hulboy DL Kinch MS Matrisian LM Hiebert SW 《Molecular and cellular biology》2000,20(16):5828-5839
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TEL is a sequence-specific transcriptional repressor. 总被引:6,自引:0,他引:6
R G Lopez C Carron C Oury P Gardellin O Bernard J Ghysdael 《The Journal of biological chemistry》1999,274(42):30132-30138
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Transformation of hematopoietic cell lines to growth-factor independence and induction of a fatal myelo- and lymphoproliferative disease in mice by retrovirally transduced TEL/JAK2 fusion genes. 总被引:22,自引:0,他引:22
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J Schwaller J Frantsve J Aster I R Williams M H Tomasson T S Ross P Peeters L Van Rompaey R A Van Etten R Ilaria Jr P Marynen D G Gilliland 《The EMBO journal》1998,17(18):5321-5333
Recent reports have demonstrated fusion of the TEL gene on 12p13 to the JAK2 gene on 9p24 in human leukemias. Three variants have been identified that fuse the TEL pointed (PNT) domain to (i) the JAK2 JH1-kinase domain, (ii) part of and (iii) all of the JH2 pseudokinase domain. We report that all of the human TEL/JAK2 variants, and a human/mouse chimeric hTEL/mJAK2(JH1) fusion gene, transform the interleukin-3 (IL-3)-dependent murine hematopoietic cell line Ba/F3 to IL-3-independent growth. Transformation requires both the TEL PNT domain and JAK2 kinase activity. Furthermore, all TEL/JAK2 variants strongly activated STAT 5 by phosphotyrosine Western blots and by electrophoretic mobility shift assays (EMSA). Mice (n = 40) transplanted with bone marrow infected with the MSCV retrovirus containing either the hTEL/mJAK2(JH1) fusion or its human counterpart developed a fatal mixed myeloproliferative and T-cell lymphoproliferative disorder with a latency of 2-10 weeks. In contrast, mice transplanted with a TEL/JAK2 mutant lacking the TEL PNT domain (n = 10) or a kinase-inactive TEL/JAK2(JH1) mutant (n = 10) did not develop the disease. We conclude that all human TEL/JAK2 fusion variants are oncoproteins in vitro that strongly activate STAT 5, and cause lethal myelo- and lymphoproliferative syndromes in murine bone marrow transplant models of leukemia. 相似文献
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TEL,a putative tumor suppressor,induces apoptosis and represses transcription of Bcl-XL 总被引:3,自引:0,他引:3
Irvin BJ Wood LD Wang L Fenrick R Sansam CG Packham G Kinch M Yang E Hiebert SW 《The Journal of biological chemistry》2003,278(47):46378-46386
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Structural analysis of the autoinhibition of Ets-1 and its role in protein partnerships 总被引:3,自引:0,他引:3
Garvie CW Pufall MA Graves BJ Wolberger C 《The Journal of biological chemistry》2002,277(47):45529-45536
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Targeted disruption of the Mn1 oncogene results in severe defects in development of membranous bones of the cranial skeleton
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Meester-Smoor MA Vermeij M van Helmond MJ Molijn AC van Wely KH Hekman AC Vermey-Keers C Riegman PH Zwarthoff EC 《Molecular and cellular biology》2005,25(10):4229-4236