Investigations on the ethnic variability of the ABO blood group polymorphism in Iran

112 Iranian population samples with a total of 600954 individuals are analyzed concerning the ethnic variability of ABO allele frequencies. The genetic heterogeneity within and between these population samples is considerable. This heterogeneity is discussed with regard to the ethnohistory of Iran. The most striking ABO allele frequencies are observed in Assyrians, Armenians and Zoroastrians, which differ extremely from that of all the other hitherto studied ethnic groups of Iran. Obviously varying ABO allele frequencies are seen also in Yazdis as well as in Turkomans and Arabs living in Iran. And finally the Iranian Jews reveal clear frequency differences in comparison with all the other Iranian population groups. It can be assumed that the specific ABO allele frequencies found in the above mentioned ethnic groups are connected with their different geographical origin as well as with their marked endogamy.     

Genetics and rheumatoid arthritis susceptibility in Iran

Rheumatoid arthritis (RA) is an autoimmune disorder with a number of risk factors, including both genetic and environmental. A number of RA risk associated genomic loci has been identified. In this review, we summarize the association of genetic factors with RA reported in population studies in Iran. No significant association was found between the majority of genetic factors identified in other populations and risk for RA in the Iranian subjects. This conflicting result could be due to the ethnic differences and diversity that are present in Iran. We conclude that there is a need to investigate larger groups of Iranian subjects, encompassing different regions of Iran, to either prove or refute these initial findings.     

Review article: Polonia studies and the collapse of Communism

This paper asks to what extent Suriname's consociational democracy still rests on its historically shaped meta-ideology of ethnic essentialism. Based on ethnographic data of the country's national elections in 2010, I suggest that the ‘ethnic taboo’ of ethnic mobilization by politicians was present to a certain extent. However, this taboo was challenged by the nationalist turn of Desi Bouterse's National Democratic Party. Furthermore, when considering voting behaviour and that of ethnically mixed Doglas in particular, we see that Surinamese politics is more complex. I will argue that while we have been thinking about Surinamese politics as being on a par with ethnic groupings, these 2010 elections were not simply about ethnicity. Ethnicity may have informed but did not fully explain people's political choices, because people are too complex to be captured in an exclusively ethnic category, and because the Surinamese political system is too complex to maintain clear ethnic categories.     

Ancient migratory events in the Middle East: new clues from the Y-chromosome variation of modern Iranians

Knowledge of high resolution Y-chromosome haplogroup diversification within Iran provides important geographic context regarding the spread and compartmentalization of male lineages in the Middle East and southwestern Asia. At present, the Iranian population is characterized by an extraordinary mix of different ethnic groups speaking a variety of Indo-Iranian, Semitic and Turkic languages. Despite these features, only few studies have investigated the multiethnic components of the Iranian gene pool. In this survey 938 Iranian male DNAs belonging to 15 ethnic groups from 14 Iranian provinces were analyzed for 84 Y-chromosome biallelic markers and 10 STRs. The results show an autochthonous but non-homogeneous ancient background mainly composed by J2a sub-clades with different external contributions. The phylogeography of the main haplogroups allowed identifying post-glacial and Neolithic expansions toward western Eurasia but also recent movements towards the Iranian region from western Eurasia (R1b-L23), Central Asia (Q-M25), Asia Minor (J2a-M92) and southern Mesopotamia (J1-Page08). In spite of the presence of important geographic barriers (Zagros and Alborz mountain ranges, and the Dasht-e Kavir and Dash-e Lut deserts) which may have limited gene flow, AMOVA analysis revealed that language, in addition to geography, has played an important role in shaping the nowadays Iranian gene pool. Overall, this study provides a portrait of the Y-chromosomal variation in Iran, useful for depicting a more comprehensive history of the peoples of this area as well as for reconstructing ancient migration routes. In addition, our results evidence the important role of the Iranian plateau as source and recipient of gene flow between culturally and genetically distinct populations.     

Experts against precaution: analyzing the process of biosafety regulation in Iran

The process of preparing and enacting a biosafety law in Iran lasted more than a decade. This paper examines the process of biosafety policy-making in Iran in relation to the Cartagena Protocol on Biosafety (CPB) and to domestic Iranian factors. While some scholars argued that the CPB would be influential in developing countries, our findings indicate that it was not particularly important in Iranian biosafety legislation. This paper outlines the internal Iranian political processes, which initially envisaged a very precautionary approach, but which concluded with a biosafety law designed to promote the adoption of these technologies. Reference will be made to the changing influence of expert biotechnologists on policy-making. The dominance of domestic policy considerations, compared to CPB provisions, implies that signing the CPB does not imply that national regimes will converge on a common model, based on the text of the CPB.     

Mitochondrial DNA sequence diversity in three ethnic populations from the South-west Iran: a preliminary study

To investigate the genetic structure of human populations in the South-west region of Iran, mitochondrial first hypervariable DNA sequences were obtained from 50 individuals representing three different ethnic groups from Khuzestan Province. Studied groups were Shushtari Persians and Chahar Lang Bakhtiyaries from Indo-European-speaking populations and Bani Torof Arabs from Semitic-speaking linguistic families. Genetic analysis of mtDNA data showed high similarity of Chahar Lang Bakhtiyaries with other Iranian Indo-European-speaking populations while Shushtaries and Bani Torofs had a closer affinity with Semitic-speaking groups rather than to other Iranian populations. The relationship of Chahar Lang Bakhtiyaries and Bani Torof Arabs with their neighbor populations can be explained by linguistic and geographic proximity. Whereas, the greater similarity of Shushtari Persians with West Asian Arabs is probably according to high gene flow between them. This article represents a preliminary study of three major ethnic groups of South-west Iran which investigates the potential genetic substructure of the region.     

‘Arab invasion’ and decline,or the import of European racial thought by Iranian nationalists

Historical research on western racial theories has grown exponentially in the past few years. A number of scholars have also investigated various cases of ethnic prejudice beyond the western pale, for instance against Koreans in Japan or Muslims in India. Yet, little attention has been given to the modalities in which European nineteenth-century racial thought was adopted in other parts of the world. This article attempts to broach a discussion on this under-analysed aspect of race studies by reviewing one case, that of Arab-hatred in modern Iran. I argue that the intense hatred of Arabs in Iranian nationalist texts derives from a racialized vision of Iranian history born in nineteenth-century European texts. Racialized historiography was selectively imported by the ideologues of Iranian nationalism as it allowed them to explain Iran's weakness in terms of a loss of racial purity.     

UNO … . What happened to autonomy? Politics and ethnicity on Nicaragua's Atlantic Coast

Current debates surrounding the ethnic mobilization of indigenous groups are explored with reference to Nicaragua's Atlantic Coast region. The Autonomy Project, promoted under the revolutionary government of the 1980s, inspired new forms of regional multi‐ethnic forms of mobilization and, in so doing, eschewed nationalistic claims associated with the resurgence of ethnicity elsewhere. The fate of the principle of ethnic autonomy is subsequently examined in the wake of the defeat of the Sandinistas in the elections held in 1990. Evidence suggests that domestic political conditions as well as international political and economic pressure have been crucial in undermining the autonomy process. This, in turn, has had important consequences for ethnic identity formation in the region, since a combination of pressure from international agencies, the United States government and multinational companies in conjunction with the UNO alliance have undermined educational and employment as well as political initiatives built around old and new ethnic groupings. Examples of bilingualism and initiatives to control and protect the region's resources are shown to have suffered directly as a result of the increased activity of multinationals, the privatization programmes of the Chomorro government and efforts to bypass local political structures. A local radio station, which also played a role in promoting multi‐ethnicity in the region, was similarly under threat. In conclusion, and drawing on wider debates, it is argued that Nicaragua's Atlantic Coast provides an important example of the interpenetration of local and global pressures in the development of ethnic politics. The analysis of changes on the Atlantic Coast during the period of the revolution and after the defeat of the Sandinistas in 1990 allows us to assess their impact on changing forms of cultural and ethnic identity in the region. The article argues that the scope for ethnic autonomy, including new and empowering forms of regional multi‐ethnic identity, is seen to be profoundly contingent on political circumstances which themselves cannot be considered independently of wider international and economic conditions.     

Assessment of patrilineal gene pool of the Iranian Azeris

The Iranian Azeris are the largest ethno-linguistic minority in Iran who live mainly in the north-west part of the country. Located in the crossroad of ancient human migrations the Iranian Azeris bear the complicated historical influence of the region in their gene pool. Despite the importance of Iranian Azeris in reconstructing the historical event of the Middle-East, their (genetic) origin still remains heavily disputed. In this study we tried to evaluate the rates of genetic contribution of possible source populations (namely, indigenous Iranian, Caucasian, and Central Asian) in the gene pool of modem Iranian Azeris through paternally inherited Y-chromosomal 6 STR markers. The assessment of genetic distances reveals that the Iranian Azeris are mixed population with substantial North Caucasian genetic contribution being genetically much closer to their immediate neighboring ethnic groups. Based on the results of admixture analysis we can conclude that there are significant Caucasian and no visible Central Asian contribution to the gene pool of modern Iranian Azeris.     

A new phenogroup in the horse D system of red cell alloantigens found in the Caspian pony

A new D blood group phenogroup consisting of the specificities adeo was observed in a stallion family of Caspian ponies from Iran. An additional six undescribed genetic variants were seen in a total of 82 Iranian horses. This result suggests extensive new genetic variation may be present in domestic horses from geographic regions that have not yet received scientific attention.     

"Fewer children, better life" or "as many as God wants"? Family planning among low-income Iranian and Afghan refugee families in Isfahan, Iran

In the West it is often assumed that religion (esp. Islam) and contraception are mutually exclusive. Yet, the Islamic Republic of Iran has one of the most successful family-planning programs in the developing world, and is often looked to as a potential model for other Muslim countries. Although Iran's family-planning program has been extremely successful among Iranians, it has been far less successful among Afghan refugees and other ethnic groups. Afghans and Iranians both seek services in Iran's public health sector for family health care, treatment of infectious disease, and childhood vaccinations. On these occasions, all adult married patients are strongly encouraged to use family planning to reduce the number of offspring. In this article, we explore how Iran's family-planning program is differentially perceived and utilized among low-income Iranian and Afghan refugee families in rural and urban locations. Particular attention is given to how different interpretations of Islam may or may not influence reproductive health-related behaviors and how cultural factors influence reproductive strategies.     

Iranian human genome project: Overview of a research process among Iranian ethnicities

The Human Genome Project (HGP) refers to the international scientific research program, formally begun in October 1990 and completed in 2003, mainly designated to discover all the human genes, analyzing the structure of human DNA and determining the location of all human genes and also making them accessible for further biological and medical investigations. With the appropriate rationale approach, a similar study has been held in Iran. The study of human genome among Iranian ethnicities (IHGP) has been attempted formally in 2000 through a detailed and fully programmed research among all the major ethnic groups by more than 1,900 samples from all over Iran based on the main demographical and anthropological findings and formally known criteria considered for the international HGP. This paper overviewed the process of the research in the terms of program goals, primary data collection, research designation and methodology and also practical aspects and primary findings of the Iranian genome project and its progress during a nearly 5-year period.     

Minority politics in the Middle East and North Africa: the prospects for transformative change

This special issue explores the prospects for what Jacob Mundy calls ‘transformative minority politics’ in the Middle East and North Africa (MENA) region – that is, a form of minority politics that strengthens democratic reform in the region, and that helps deepen a culture of human rights and democratic citizenship. The cases examined in the special issue include the Amazigh in North Africa, the Copts in Egypt, the Kurds in Iraq, the Palestinians in Israel, the ‘minoritarian’ regimes in Syria and Bahrain, and the various ethnic minorities in Iran. In this introduction, we try to situate this debate in a larger historical and international context, identifying some of the factors that might help support a new transformative minority politics in the region, while also emphasizing the factors that have inhibited it in the past, and why they remain powerful.     

Modelling the potential distribution of Mesalina watsonana (Stoliczka, 1872) (Reptilia: Lacertidae) on the Iranian Plateau

The Persian Long-tailed Desert Lizard, Mesalina watsonana, is one of the most common and most widely distributed lizards on the Iranian Plateau extending from Iran to Pakistan and Afghanistan. The species is frequently encountered in various types of habitats. We collected over 600 distributional records from available literature, museum collections, and our own field work and used bioclimatic and land cover characteristics to develop a model of potential distribution for M. watsonana. According to the model, the most important factors limiting the distribution of M. watsonana are: precipitation in wettest quarter exceeding 250–300 mm, precipitation in coldest quarter lower than 40 mm and exceeding 250 mm, altitudes above 2500 m and slopes steeper than 10.5°. The model suggests that most of the Iranian Plateau is suitable for the species except for some isolated areas such as the Dasht-e Kavir and Dasht-e Lut deserts in Iran, Helmand basin in Afghanistan, the Karakum Desert in Turkmenistan, the western Chagai-Kharan deserts of Pakistani Balochistan, and Thar and Cholistan deserts in eastern Pakistan. The most important factor in these regions appears to be the extremely low rainfall during coldest quarter of the year. The outer boundary of the distribution of M. watsonana follows important biogeographic barriers that are also clearly delimited by climatic conditions.     

A Hu sheep genome with the first ovine Y chromosome reveal introgression history after sheep domestication

The Y chromosome plays key roles in male fertility and reflects the evolutionary history of paternal lineages. Here, we present a de novo genome assembly of the Hu sheep with the first draft assembly of ovine Y chromosome(o MSY), using nanopore sequencing and Hi-C technologies. The o MSY that we generated spans 10.6 Mb from which 775 Y-SNPs were identified by applying a large panel of whole genome sequences from worldwide sheep and wild Iranian mouflons. Three major paternal lineages(HY1a, HY1b and HY2) were defined across domestic sheep, of which HY2 was newly detected. Surprisingly, HY2 forms a monophyletic clade with the Iranian mouflons and is highly divergent from both HY1a and HY1b. Demographic analysis of Y chromosomes, mitochondrial and nuclear genomes confirmed that HY2 and the maternal counterpart of lineage C represented a distinct wild mouflon population in Iran that diverge from the direct ancestor of domestic sheep, the wild mouflons in Southeastern Anatolia. Our results suggest that wild Iranian mouflons had introgressed into domestic sheep and thereby introduced this Iranian mouflon specific lineage carrying HY2 to both East Asian and Africa sheep populations.     

Ethnic and Geographic Differentiation of Helicobacter pylori within Iran

The bacterium Helicobacter pylori colonizes the human stomach, with individual infections persisting for decades. The spread of the bacterium has been shown to reflect both ancient and recent human migrations. We have sequenced housekeeping genes from H. pylori isolated from 147 Iranians with well-characterized geographical and ethnic origins sampled throughout Iran and compared them with sequences from strains from other locations. H. pylori from Iran are similar to others isolated from Western Eurasia and can be placed in the previously described HpEurope population. Despite the location of Iran at the crossroads of Eurasia, we found no evidence that the region been a major source of ancestry for strains across the continent. On a smaller scale, we found genetic affinities between the H. pylori isolated from particular Iranian populations and strains from Turks, Uzbeks, Palestinians and Israelis, reflecting documented historical contacts over the past two thousand years.     

Ethnocentrism and ideology*

Ethnic politics is a paradoxical phenomenon in France. While predominant French ideologies and institutional arrangements reinforce a ‘no ethnic politics’ model, there have been substantive challenges to this traditional model, including changes in state practices, and the political emergence of Franco‐Maghrebis and the immigrant association movement. Using the affaire des foulards [headscarves affair] of 1989 as a case‐study, the article seeks to clarify the ethnic politics paradox in France. I argue that the emergence and configuration of ethnic politics in France are being shaped by a series of constraints. These constraints are reflected in the ways in which the headscarves affair was created, defined, and managed. I suggest that the constraints are rooted not only in French ideologies and institutional arrangements, but also in the ‘nationalist logic’ of contemporary French immigration politics, the integrationist strategies of Franco‐Maghrebi groups, and the immigré perspective of the state and political community.     

Researching and teaching in the field of ethnic and racial studies: a view from continental Europe

In the first part of the article, I make a few general comments inspired by the reading of Banton's article. I claim that the field of ethnic and racial studies is often dominated by an "Anglo-Americentric" vision that leads to a negation of the variety of approaches to ethnic and racial studies throughout the world. I claim that a process of "decentration" is necessary in order to foster the diversity in our field. In the second part of the article, I make specific comments inspired by my experience as researcher and teacher in a fragmented society such as Belgium. One conclusion is that our teaching has to be contextualized in order to avoid misunderstandings and the reproduction of inadequate conceptions and confusions about ethnic and racial issues among our students.     

Conservative populist politics and the remaking of the “white working class” in the USA

For decades, scholars and journalists have intricately tied presidential elections to the idea of a struggling “white working class.” They explained the 2016 presidential election by investigating the politics of low- or middle-income white conservative voters. This article instead focuses on the way in which white low-wage and unemployed small town residents question, distrust, and embrace conservative populist politics. The paper first explores how conservative populism and the media response are remaking the white working class along cultural and racial lines. Drawing from research conducted in a predominantly white former manufacturing town in central Maine, I then document that some poor and low-wage white workers distrust conservative populist politicians and are angry about being pushed aside by business-first politics. While populist and neoliberal politics have contributed to a remaking of the white working class around a white worker ideal, the concomitant decline in the social safety net and good jobs has been generating a sense of betrayal among those who are struggling the most. The article thus offers an alternative to the white working class caricature and argues that a contradictory consciousness results from workers living within and reacting against economic precarity and conservative populism.     

Analysis of Coat Protein of Peanut stunt virus Subgroup II Isolates from Alfalfa Fields in West Iran

Alfalfa fields in three western provinces of Iran were surveyed for Peanut stunt virus (PSV) during 2011 and 2012. Forty‐seven of 115 samples tested (41%) were infected with PSV. Phylogenetic analysis using coat protein (CP) gene sequences showed that the Iranian isolates belong to the subgroup II of PSV. Pairwise identity analysis revealed four groups representing four phylogenetic subgroups. PSV strains in subgroups III and IV are closely related to each other, as supported by the lowest nucleotide diversity, high pairwise nucleotide identity and high haplotype diversity as evidence of a recent population expansion after a genetic bottleneck. Using the maximum likelihood method, amino acid 86S in the CP gene of the Iranian PSV isolates was found to be under positive selection, although the likelihood ratio test statistics is not significant. This is the first report of the occurrence and phylogenetic relationships of Iranian PSV isolates in west Iran.