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Codon identity regulates mRNA stability and translation efficiency during the maternal‐to‐zygotic transition 下载免费PDF全文
Ariel A Bazzini Florencia del Viso Miguel A Moreno‐Mateos Timothy G Johnstone Charles E Vejnar Yidan Qin Jun Yao Mustafa K Khokha Antonio J Giraldez 《The EMBO journal》2016,35(19):2087-2103
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Targeted mRNA translation is emerging as a critical mechanism to control gene expression during developmental processes. Exciting new findings have revealed a critical role for regulatory elements within the mRNA untranslated regions to direct the timing of mRNA translation. Regulatory elements can be targeted by sequence‐specific binding proteins to direct either repression or activation of mRNA translation in response to developmental signals. As new regulatory elements continue to be identified it has become clear that targeted mRNAs can contain multiple regulatory elements, directing apparently contradictory translational patterns. How is this complex regulatory input integrated? In this review, we focus on a new challenge area—how sequence‐specific RNA binding proteins respond to developmental signals and functionally integrate to regulate the extent and timing of target mRNA translation. We discuss current understanding with a particular emphasis on the control of cell cycle progression that is mediated through a complex interplay of distinct mRNA regulatory elements during Xenopus oocyte maturation. Mol. Reprod. Dev. 77: 662–669, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
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Yongjian Zhang Xiangyu Wu Lixing Yuan 《The Plant journal : for cell and molecular biology》2020,102(4):823-837
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