Engaging with the past: how #BlackLivesMatter points us to our predecessors and calls us to hope

This paper focuses on the contributions of Chris Lebron's book The Making of Black Lives Matter: The History of an Idea. Specifically, I examine his discussion of James Baldwin, Martin Luther King, Jr., and Audre Lorde and their opinions about love for their community, black self-actualization, and black liberation. I consider whether or not rage should play a role in our opinions about the #BlackLivesMatter movement and discuss whether or not it hurts the pursuit of freedom. I agree with the importance to look to the past in order to inform our political behaviour moving forward. Nonetheless, if we are to align with the #BlackLivesMatter movement, we must be willing to challenge what is often considered to be “proper” dissent. The review concludes with hypotheses about what black Americans should do as we work to reimagine a society where oppression is not integral to the maintenance of the American project.     

The Fate of Utopia: Adaptive Tactics in Four Japanese Groups

Utopian groups, like other kinds of revitalization movements, work to create a new "cultural end-state." This implies, at the very least, a mild rejection of some of the present norms and institutions of the ambient society. To be allowed to continue its work, a utopian community must adopt to the demands of its cultural milieu, but at the same time it must do so in ways consonant with the group self-image. This essay reports on the adaptive tactics used by four Japanese utopian groups in dealing with present-day state institutions and with the public at large. It argues that in the study of utopian groups—and by extension revitalizations and revolutions—we must examine adaptive tactics as carefully as group goals if we hope to understand the fate of purposeful action in complex civilizations.     

WILL BIOMEDICAL ENHANCEMENTS UNDERMINE SOLIDARITY,RESPONSIBILITY, EQUALITY AND AUTONOMY?

Prominent thinkers such as Jurgen Habermas and Michael Sandel are warning that biomedical enhancements will undermine fundamental political values. Yet whether biomedical enhancements will undermine such values depends on how biomedical enhancements will function, how they will be administered and to whom. Since only few enhancements are obtainable, it is difficult to tell whether these predictions are sound. Nevertheless, such warnings are extremely valuable. As a society we must, at the very least, be aware of developments that could have harmful consequences. Indeed, if important values were to be jeopardized, we should take appropriate measures to protect them. This paper focuses on four central values: solidarity, personal responsibility, equality and autonomy. It delineates the conditions under which biomedical enhancements would undermine these values. It also details the circumstances under which these values would be unaffected by enhancements as well as those under which they would be promoted. Specifying these conditions is valuable; it would enable society to prepare appropriate ethical guidelines and policy responses in advance.     

Human welfare and its connection to nature: What have we learned from crop pollination studies?

Human welfare depends on the function of natural systems. This idea is paradigmatic to ecologists and has been the theme of a growing branch of applied ecology. I examine the narrative of human dependence on nature by considering the literature on crop pollination by animals and its importance for food production. Making the connections between human welfare and natural systems is seen as a way to better motivate society to make better decisions, but the debate around crop pollination has been surprisingly contentious. There have been confusing messages, disagreements on the facts, an unfortunate focus on dire projections for the future and a lesser focus on solutions. Most of these problems arise not from poor science but instead from poor communication of complex ideas and differences in perspective, such as the deep disciplinary gap between agricultural scientists and ecologists. By understanding these problems, we can improve the way we do our science and communicate our ideas. I argue that ecologists should continue to communicate the principle that human welfare depends on the function of natural systems and discuss how we can do so in a way that is more genuinely connected to society's needs, such as growing food. If we succeed, we will be changing an intellectually interesting conversation into a dialogue that influences how society interacts with nature.     

WHO ARE THE BENEFICIARIES?

Is it defensible that society spends money on medical or research projects intended to help people solve their fertility problems? Suppose that we want to answer this question from the point of view of a utilitarian cost-benefit analysis. The answer to the question then depends, of course, on how expensive these projects turn out to be, relative to the costs of other possible projects. But it depends also on how we assess the benefits of these projects. To whom do they accrue? Who are the beneficiaries of these projects?     

When should potentially false research findings be considered acceptable?

Ioannidis estimated that most published research findings are false, but he did not indicate when, if at all, potentially false research results may be considered as acceptable to society. We combined our two previously published models to calculate the probability above which research findings may become acceptable. A new model indicates that the probability above which research results should be accepted depends on the expected payback from the research (the benefits) and the inadvertent consequences (the harms). This probability may dramatically change depending on our willingness to tolerate error in accepting false research findings. Our acceptance of research findings changes as a function of what we call "acceptable regret," i.e., our tolerance of making a wrong decision in accepting the research hypothesis. We illustrate our findings by providing a new framework for early stopping rules in clinical research (i.e., when should we accept early findings from a clinical trial indicating the benefits as true?). Obtaining absolute "truth" in research is impossible, and so society has to decide when less-than-perfect results may become acceptable.     

The aged: medical and social aspects

Physical health is affected by physiological aging that impacts on all tissues and organs, notably sensorial systems (hearing, sight), the locomotory and the immunological systems (lowering of resistance to infections). There is an increase with age in the incidence of many cancers (particularly breast, prostate, and colon cancers) and cardiovascular diseases. Regular check-ups are useful in order to take appropriate measures in time. It is important that people maintain regular physical activity and a balanced diet even up to an advanced age and the elderly must learn to adapt themselves to the ever-changing abilities of their organism. It is possible to slow down the aging process through good hygiene and often to maintain autonomy until the end of life. Mental health is threatened by impairment of mental functions, depressive tendencies, and the risk of senile dementia that cannot be foreseen or avoided. It appears that keeping intellectually active and having a good level of education impact favorably on mental aging. Social health depends, for a large part, on the way society accepts and treats the elderly. They must be kept integrated into society and allowed to live at home for as long as possible. Any measures of rejection, discrimination, and exclusion should be opposed. The dignity of the elderly must be respected and activities giving them a feeling of usefulness should be encouraged. It is important to help families who care for their parents at home, to develop and evaluate healthcare networks, and encourage medical professionals and social services to work together. The change in the demographic structure of France is a considerable phenomenon requiring a long-term strategy and not only superficial and cosmetic measures.     

Plant and Soil Nematodes: Societal Impact and Focus for the Future.

Plant and soil nematodes significandy impact our lives. Therefore, we must understand and manage these complex organisms so that we may continue to develop and sustain our food production systems, our natural resources, our environment, and our quality of life. This publication looks specifically at soil and plant nematology. First, the societal impact of nematodes and benefits of nematology research are briefly presented. Next, the opportunities facing nematology in the next decade are outlined, as well as the resources needed to address these priorities. The safety and sustainability of U.S. food and fiber production depends on public and administrative understanding of the importance of nematodes, the drastic effects of nematodes on many agricultural and horticultural crops, and the current research priorities of nematology.     

Synthesis and evaluation of the structural elements in alkylated tetrahydroisoquinolines for binding to CNS receptors

Diseases of the CNS are often complex and involve multiple receptor systems and thus, the treatment options for these diseases must focus on targeting the multiple receptors implicated in the various disorders. Schizophrenia and depression are examples of such diseases and their pharmacotherapy thus depends on agents which target multiple receptors including the dopamine, serotonin and even cholinergic receptors at the same time. In our previous campaign to find multi-receptor ligands, we have identified the benzothiazole 1a as an initial lead molecule. In the current work, we have expanded the structure affinity relationship (SAFIR) of 1a resulting in the identification of a partially restrained butyrophenone 3j as a potent and selective dual 5-HT_1A and 5-HT₇ receptor ligand. It is expected that compound 3j may serve as a new lead for further development in our search for newer and novel ligands with the potential to treat diseases of CNS origin.     

THE PROBLEM OF LUPUS ERYTHEMATOSUS

Lupus erythematosus is a challenging disease. Progress in our knowledge of it will come only from intensive research, but in the meantime the practicing dermatologist must be on the alert to make his own observations, to follow current literature carefully and welcome new discoveries from any reliable source. The disease is not the sole property of dermatology; we should rejoice at the interest of pathologists and internists in this condition and work closely with them.     

“The Simulacra of Morality”: Islamic Veiling, Religious Politics and the Limits of Liberalism

On December 17, 2003, French President Jaques Chirac went on television to explain the immediate necessity of passing a law recently proposed by the Stasi commission. This commission had been empowered to explore the failures of the last thirty years of French immigration policy in terms of integration. It had also been specifically instructed to investigate threats to the concept of laicite, the rigorous French version of secularism and the separation of the Church and the State. Chirac explained that, following the commission’s advice as well as that of numerous experts, he had centered on a policy to deal with these issues: We shall do so by bringing to life the principle of secularism, which is a pillar of our constitution. It expresses our wish to live together in respect, dialogue and tolerance. Secularism guarantees freedom of conscience. It protects the freedom to believe or not to believe. He then expanded upon what this freedom requires: It is the neutrality of the public sphere which enables the harmonious existence side by side of different religions. Like all freedoms, the freedom to express one’s faith can only have limits in the freedom of others, and in the compliance with rules of life in society. Religious freedom, which our country respects and protects, must not be abused, it must not call general rules into question, and it must not infringe the freedom of belief of others. Finally, Chirac, building to a rhetorical climax, came to the essence of the new law which had provoked so much commentary around the world: In all conscience, it is my view that the wearing of clothes or of symbols which conspicuously demonstrate religious affiliations must be banned in state schools. The hypothesis which I wish to advance is that in the actual world in which we inhabit the language of morality is in the same state of grave disorder as the language of natural science is in the imaginary world which I described. What we possess are the fragments of a conceptual scheme... we posses indeed simulacra of morality... but we have lost our comprehension, both theoretical and practical, of morality.     

Optimal Information Transfer in the Cortex through Synchronization

In recent experimental work it has been shown that neuronal interactions are modulated by neuronal synchronization and that this modulation depends on phase shifts in neuronal oscillations. This result suggests that connections in a network can be shaped through synchronization. Here, we test and expand this hypothesis using a model network. We use transfer entropy, an information theoretical measure, to quantify the exchanged information. We show that transferred information depends on the phase relation of the signal, that the amount of exchanged information increases as a function of oscillations in the signal and that the speed of the information transfer increases as a function of synchronization. This implies that synchronization makes information transport more efficient. In summary, our results reinforce the hypothesis that synchronization modulates neuronal interactions and provide further evidence that gamma band synchronization has behavioral relevance.     

One Conservation: the integrated view of biodiversity conservation

The current global situation requires urgent decision-making to reverse processes of mass extinction of thousands of species. As a way of showing the importance of joint actions in this process, we aim to present the concept of One Conservation as a new proposal for the integration of sustainability, in situ and ex situ conservation for the restoration of ecosystems. According to the United Nations, we are beginning the decade of ecosystem restoration and in association with the International Union for Conservation of Nature guidelines, we can join efforts in the conservation of the planet. The survival of many species of wild animals depends on the management of populations currently maintained in ex situ conditions (under human care). To facilitate the exchange of genetic material between in situ and ex situ populations, reproductive biotechniques have become a great tool, making it possible to restore species in their natural environments. For effective conservation to occur, there must be an integrated view of the problem as a whole, and action for solutions must take place jointly by different spheres of society. Even more, conservation must be carried out by the public sector, the private sector, the third sector, and not less importantly, the agricultural sector. Therefore, One Conservation is defined as an interconnection between ex situ and in situ conservation plans, anthropic actions in the environment, and research in different areas that encompass conservation.     

Continuous optimization algorithms for tuning real and integer parameters of swarm intelligence algorithms

The performance of optimization algorithms, including those based on swarm intelligence, depends on the values assigned to their parameters. To obtain high performance, these parameters must be fine-tuned. Since many parameters can take real values or integer values from a large domain, it is often possible to treat the tuning problem as a continuous optimization problem. In this article, we study the performance of a number of prominent continuous optimization algorithms for parameter tuning using various case studies from the swarm intelligence literature. The continuous optimization algorithms that we study are enhanced to handle the stochastic nature of the tuning problem. In particular, we introduce a new post-selection mechanism that uses F-Race in the final phase of the tuning process to select the best among elite parameter configurations. We also examine the parameter space of the swarm intelligence algorithms that we consider in our study, and we show that by fine-tuning their parameters one can obtain substantial improvements over default configurations.     

Understanding how nature works: Five pathways towards a more ecologically literate world – A perspective

The sustainability of human life on Earth depends upon the integrity of the relationship between humanity and nature. Natural systems support humanity, and knowledge and understanding of how nature works form the foundation of ecological literacy. It is ecological literacy, and science literacy in general, that underpins our capacity as humans to make well‐informed decisions about how to live in sustainable ways. It is of concern that levels of ecological knowledge and understanding within many contemporary human communities may be too low to enable effective decision‐making in support of sustainable human settlements. Our concern led to an exploration of the concept of ecological literacy and the assessment of a sample of South Australian adults. We found that while ecological literacy can vary significantly in correlation with a range of socio‐demographic and psychographic characteristics, no one factor is necessarily more critical than another. Based on this work, we have identified five pathways for growing eco‐literate communities. While the patterns and drivers of ecological knowledge and understanding naturally vary between cultures and communities, our findings certainly invite serious consideration for a society, and indeed a world, that aspires to cultivate informed citizenry, leadership and governance with capacity for building sustainable human settlements.     

Current trends and future directions in flower development research

Flowers, the reproductive structures of the approximately 400 000 extant species of flowering plants, exist in a tremendous range of forms and sizes, mainly due to developmental differences involving the number, arrangement, size and form of the floral organs of which they consist. However, this tremendous diversity is underpinned by a surprisingly robust basic floral structure in which a central group of carpels forms on an axis of determinate growth, almost invariably surrounded by two successive zones containing stamens and perianth organs, respectively. Over the last 25 years, remarkable progress has been achieved in describing the molecular mechanisms that control almost all aspects of flower development, from the phase change that initiates flowering to the final production of fruits and seeds. However, this work has been performed almost exclusively in a small number of eudicot model species, chief among which is Arabidopsis thaliana. Studies of flower development must now be extended to a much wider phylogenetic range of flowering plants and, indeed, to their closest living relatives, the gymnosperms. Studies of further, more wide-ranging models should provide insights that, for various reasons, cannot be obtained by studying the major existing models alone. The use of further models should also help to explain how the first flowering plants evolved from an unknown, although presumably gymnosperm-like ancestor, and rapidly diversified to become the largest major plant group and to dominate the terrestrial flora. The benefits for society of a thorough understanding of flower development are self-evident, as human life depends to a large extent on flowering plants and on the fruits and seeds they produce. In this preface to the Special Issue, we introduce eleven articles on flower development, representing work in both established and further models, including gymnosperms. We also present some of our own views on current trends and future directions of the flower development field.     

The Invisibility of Disability: Using Dance to Shake from Bioethics the Idea of ‘Broken Bodies’

Complex social and ethical problems are often most effectively solved by engaging them at the messy and uncomfortable intersections of disciplines and practices, a notion that grounds the InVisible Difference project, which seeks to extend thinking and alter practice around the making, status, ownership, and value of work by contemporary dance choreographers by examining choreographic work through the lenses of law, bioethics, dance scholarship, and the practice of dance by differently‐abled dancers. This article offers a critical thesis on how bioethics has come to occupy a marginal and marginalizing role in questions about the differently‐abled body. In doing so, it has rendered the disabled community largely invisible to and in bioethics. It then defends the claim that bioethics – as a social undertaking pursued collaboratively by individuals from different disciplines – must take much better notice of the body and the embodied individual if it is to better achieve its ends, which include constructing a moral and just society. Finally, this article considers how the arts, and specifically dance (and here dance by differently‐abled dancers), provides us with rich evidence about the body and our ability to respond positively to normally ‘othered’ bodies. It concludes that greater attention to empirical evidence like that being generated in InVisible Difference will help to expand the reach and significance of bioethics, and thereby its relevance to (and consciousness of) important questions about the status of bodies and bodily differences, which must be considered as central to its ambitions.     

The rhythm of rest and excess

There is a stark contrast between our attitudes to sleep and those of the pre-industrial age. In Shakespeare's Julius Caesar we are told to "Enjoy the honey-heavy dew of slumber". There seems little chance of this today, as we crave more, work more and expect more, and, in the process, abandon sleep. Our occupation of the night is having unanticipated costs for both our physical and mental health, which, if continued, might condemn whole sectors of our society to a dismal future.     

The network structure affects the fixation probability when it couples to the birth-death dynamics in finite population

The study of evolutionary dynamics on graphs is an interesting topic for researchers in various fields of science and mathematics. In systems with finite population, different model dynamics are distinguished by their effects on two important quantities: fixation probability and fixation time. The isothermal theorem declares that the fixation probability is the same for a wide range of graphs and it only depends on the population size. This has also been proved for more complex graphs that are called complex networks. In this work, we propose a model that couples the population dynamics to the network structure and show that in this case, the isothermal theorem is being violated. In our model the death rate of a mutant depends on its number of neighbors, and neutral drift holds only in the average. We investigate the fixation probability behavior in terms of the complexity parameter, such as the scale-free exponent for the scale-free network and the rewiring probability for the small-world network.