共查询到18条相似文献,搜索用时 109 毫秒
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菊三七属植物化学成分及药理作用的研究进展 总被引:1,自引:0,他引:1
菊科菊三七属植物中含有生物碱类、黄酮类、香豆素类、三萜类、甾体类及其皂苷、倍半萜类、酚酸类、脑苷脂类等化学成分,具有良好的止血、降血糖、降血压、抗肿瘤、抗炎、抗凝血等药理活性。可见,该属植物化学成分丰富,药理活性多样,极具药用及食用保健价值。本文就近年来菊三七属植物的化学成分和药理作用研究进展作一综述。 相似文献
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《天然产物研究与开发》2018,(11)
延胡索的化学成分及药理活性经过持续研究取得了系统的成果。本文以化学结构分类为线索重点对原小檗碱类、阿朴菲类、原阿片类、异喹啉类等69个生物碱和甾体、有机酸、黏液质、氨基酸和挥发油27个已确认结构的化合物进行归类整理。结合最新研究文献,阐述了延胡索在镇痛镇静、心血管系统作用、消化系统作用、抗肿瘤、抗炎领域的药理活性研究进展,以期为药材的进一步开发提供参考。 相似文献
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结合国内外文献综述了山橙属植物化学成分的研究进展,并对该属药用植物的抗肿瘤活性进行了总结。山橙属植物含有多种化学成分,主要有生物碱类以及少量三萜类、甾体类、木脂素类等。该属植物中的生物碱类成分具有显著的抗肿瘤活性。 相似文献
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结合国内外文献综述了山橙属植物化学成分的研究进展,并对该属药用植物的抗肿瘤活性进行了总结。山橙属植物含有多种化学成分,主要有生物碱类以及少量三萜类、甾体类、木脂素类等。该属植物中的生物碱类成分具有显著的抗肿瘤活性。 相似文献
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全球紫堇属Corydalis约400余种,广泛分布于北温带和非洲南部地区。在我国,该属多种物种作为民间用药具有上千年历史。紫堇属植物富含异喹啉生物碱,对该类成分通常以回流、超声加热、湿法超微粉碎法和酶解辅助技术等方法提取,并使用溶剂分离法、硅胶柱色谱法、反向填料柱色谱法、HPLC法、离子交换树脂法、高效逆流色谱法和活性引导技术等方法进行分离纯化法。紫堇属生物碱有效部位或单体成分都具有较强药理活性,现代药理学表明,该属所含生物碱类成分对心脑血管、抗肿瘤、镇痛、消炎、保肝和抗血小板凝集等均具有显著的药理作用。本文对已报道的紫堇属植物生物碱类成分的结构类型、特征、药理作用以及提取分离方法研究进行综述,为植物药用化学成分富集和安全用药提供借鉴。 相似文献
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石蒜属植物生物碱成分研究进展 总被引:4,自引:0,他引:4
石蒜属为东亚特有属。该属植物富含生物碱,且此类次生代谢产物具有细胞毒、抗疟疾、抗病毒以及对乙酰胆碱酯酶的抑制作用等活性。本文概述了该属中生物碱类成分的化学结构、药理活性及其生源途径。 相似文献
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萝Mo科马利筋族植物化学成分研究进展(Ⅱ) 总被引:1,自引:0,他引:1
综述了到目前为止,从马利筋族植物中发现的黄酮、强心甙、生物碱、萜类、苯衍生物类等成分的种类及其分布,并介绍了一些化合物的药理作用以及黄酮类和C21甾体化合物 鹅绒藤属化学分类中的作用。 相似文献
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The plant chemotaxonomical marker of Fritillaria L. is discussed in this
paper according to the information on chemical components. Plenty of evidence
shows that 5α-cevanine isosteroidal alkaloids are the characteristic constituents of
this genus. In the light of the biogensis of this kind of alkaloids, the C-13 and
C- 17 of the molecular structures may be rational positions uniting a nitrogenous
group in their biosyntheses which make two kinds of 5α-cevanine isosteroidal
alkaloids, the dihydrogen of C- 13 and C- 17 being at the state of
trans-configuration (e. g. verticine, verticinone) and at the state of cisconfiguration (e.g. delavine, chuanbeinone and songbeinine). Meanwhile, this
paper reports the existence and content of some 5α-cevanine isosteroidal alkaloids
in main Chinese fritillarias. This result reveals that there may be a relationship
between the formation of characteristic constituents on one hand and other
morphological characters and distribution of the plants concerned on the other,which encourages further investigation. 相似文献
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Nehir Unver 《Phytochemistry Reviews》2007,6(1):125-135
The Amaryllidaceae alkaloids, represent a group of isoquinoline alkaloids, which are produced almost solely by members of
the Amaryllidaceae family. The alkaloids of this family have attracted considerable amount of interest due to some important
pharmacological activities they were shown to possess. In the last decade, our phytochemical studies on four Galanthus (Amaryllidaceae) species of Turkish origin have yielded quite a number of new alkaloids with diverse structures. Among these
alkaloids, gracilines and plicamines constitute two new subgroups for the Amaryllidaceae alkaloids. The gracilines contain
an incorporated 10b,4a-ethanoiminodibenzo[b,d]pyrane skeleton. The plicamines are dinitrogenous compounds, where the oxygen atom in position 7 of a tazettine skeleton
is replaced by a nitrogen atom substituted by a pendant 4-hydroxyphenethyl moiety. One of the new alkaloids, galanthindole,
which possesses a nonfused indole ring, unlike the already known subgroups of Amaryllidaceae alkaloids, may be considered
as the prototype of a third new subgroup of the Amaryllidaceae alkaloids. Additionally, two known isoquinoline alkaloids which
do not possess one of the established skeletons of the Amaryllidaceae alkaloids, namely ( − )-capnoidine and (+)-bulbocapnine,
have been isolated from a Turkish Galanthus species. Totally, 21 new, 20 known alkaloids and 2 known lignans have been characterized. In this review, the isolation and
structure elucidation of these compounds with interesting chemical structures are described. 相似文献
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Yuxiang Huang Hexin Tan Zhiying Guo Xunxun Wu Qinglei Zhang Lei Zhang Yong Diao 《Journal of Plant Biology》2016,59(3):203-214
Indole alkaloids are widely distributed secondary metabolites that exhibit a broad range of pharmacological activities. They are synthesized through plant biosynthetic pathways involving complex enzyme activities and regulatory strategies. Since many compounds of indole alkaloids are structurally too complex to be manufactured economically by chemical synthesis, they have to be isolated from naturally grown or cultivated plants. Therefore, the biotechnological production of high-value plant secondary metabolites in cultivated cells or transgenic plants is potentially an attractive alternative. The present review describes the regulation of indole alkaloids biosynthesis, as well as their pharmacological functions in plants such as anti-microbes, anti-inflammatory and anti-tumor. Furthermore, it discusses different strategies by which the genetic engineering of indole alkaloids biosynthesis through the reconstruction of the pathway achieves high production of specific compounds. 相似文献
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Benzophenanthridine alkaloids represent a very interesting and significant group of natural products that exhibit a broad range of biological and pharmacological properties. Among this group of alkaloids, sanguinarine, nitidine, fagaronine, and chelerythrine have the potential to form molecular complexes with DNA structures and have attracted recent attention for their possible clinical and pharmacological utility. This review focuses on the interaction of these alkaloids with polymorphic DNA structures (B-form, Z-form, HL-form, and triple helical form) reported by several research groups employing various physical techniques such as spectrophotometry, spectrofluorimetry, circular dichroism, NMR spectroscopy, thermal melting, viscometry as well as thermodynamic analysis by isothermal titration calorimetry and differential scanning calorimetry to elucidate the mode and mechanism of action at the molecular level to determine the structure-activity relationship. DNA binding properties of these alkaloids are interpreted in relation to their biological activity. 相似文献
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The marine environment produces natural products from a variety of structural classes exhibiting activity against numerous disease targets. Historically marine natural products have largely been explored as anticancer agents. The indole alkaloids are a class of marine natural products that show unique promise in the development of new drug leads. This report reviews the literature on indole alkaloids of marine origin and also highlights our own research. Specific biological activities of indole alkaloids presented here include: cytotoxicity, antiviral, antiparasitic, anti-inflammatory, serotonin antagonism, Ca-releasing, calmodulin antagonism, and other pharmacological activities. 相似文献
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两头毛的化学成分及药理作用研究进展 总被引:1,自引:0,他引:1
本文综述了两头毛的化学成分和药理作用的研究进展。两头毛中主要含有生物碱、黄酮类、甾醇、三萜类和神经酰胺等多种化学成分。药理学方面研究证明:两头毛具有抗炎,抗氧化,抑菌,神经营养等活性,在临床上,两头毛作为治疗肝炎和痢疾的药物。 相似文献
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A compound C was isolated from the dry bulbs of Fritillaria unibracteata Hsiao et K. C: Hsia which belongs to a main resource species of traditional Chinese drug “Chuan Bei-mu” in Chinese Pharmacopoeia (1990 ed.). It was identified as D/E cis(22R, 25S)-20-deoxy-3β-hydroxyl-6-carbonyl-5α, 14α, 17β-cevanine by means of spectroscopic methods. It is a new alkaloid of 5α-cevanine group of isosteroidal alkaloids being attributed to the characteristic constituents of this genus, named as songbeinone. 相似文献