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Karl G. Götz Roland Biesinger 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1985,156(3):319-327
Summary The term centrophobism is introduced to describe a newly discovered modification of search behavior in the walking fruitfly,Drosophila melanogaster: the avoidance of the center of an arena after diethylether narcosis. Evidence for the effect is obtained by comparison of the tracks of etherized and non-etherized flies under the influence of olfactory attractant around the center of the arena (Fig. 3). The tracks can be distinguished by their mean radial distance from the central district of the arena. Centrophobia denotes the relative difference of the distances of etherized flies and non-etherized controls (Fig. 4).Etherized flies avoid the center of the arena in spite of the attraction of olfactory, thermal or visual cues. The avoidance is significant even in the absence of conspicuous sensory cues for the discrimination of center and surround. The centrophobia obtained in the arena can be used to estimate the efficacy of attractants in the non-etherized control flies (Figs. 6, 7).The lowest possible dose of ether sufficient to elicit narcosis is sufficient to induce centrophobia. None of the other prevalent insect anaesthetics, CO2, N2 and cold, substitutes ether in the present experiments (Figs. 8, 9).Centrophobia arises immediately after ether narcosis. Once induced the effect lasts apparently undiminished for the life time of the flies (Fig. 9).Centrophobia has been found in either sex of the 9 strains tested so far (Fig. 5). Four strains including mutants deficient in wing formation (vestigial) or learning (dunce) show either temporal decline or partial suppression of centrophobia. The anomalous properties are actually due to enhanced spontaneous centrophobism in the non-etherized control groups of these strains (Fig. 10). 相似文献
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N. P. Dubinin 《Journal of genetics》1933,27(3):443-464
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A temperature sensitive lethal allele of thewingless locus ofDrosophila melanogaster together with previously studied lethal and viable alleles in this locus, has been used to study some properties of this
locus. These studies show the existence of two lethal phases for thewingless lesion; one during embryogenesis and another during pupation. By growing embryos with temperature sensitivewingless lesion at the permissive temperature and letting the larvae develop at non-permissive temperature, a large-scale cell death
and subsequent regeneration were seen to occur in the mutant wing discs. This cell death followed by regeneration alters the
normal developmental potential of the wing disc. Disc transplantation experiments show that these discs are incapable of differentiating
into wing blade structures. 相似文献
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D. Menne H. -C. Spatz 《Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology》1977,114(3):301-312
Summary Using a fully automatized procedure and a training scheme symmetrical with respect to the visual stimuli as well as to the aversive stimulus,Drosophila could be conditioned to blue and yellow lights. With constant test conditions and variation of the light intensities during the training procedure, it could be shown that the flies respond primarily to the colour of the light.We are grateful to Dr. W. Edrich and K.-F. Fischbach for exchange of ideas. Dr. J. Bammert gave advice for the statistical treatment. 相似文献
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S. S. Prabhu 《Journal of genetics》1939,38(1-2):177-191
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In artificial populations ofDrosophila melanogaster the mutantsvermilion (v) andcinnabar (cn), both interfering with eye pigment formation, appeared to be balanced against wild type, indicating that the heterozygotesv/+ andcn/+ have a selective advantage over the respective homozygotes. In a population homozygous forv, the mutantcn in competition with its wild type allele tended to be eliminated. Ifcn was homozygous,v showed a similar tendency. Thus in competion experiments it was found that the heterozygotes for one of the two recessive genes,v andcn, ceased to be heterotic when the other recessive is homozygous. These findings are considered to be evidence for the existence of overdominance. 相似文献
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Natural variation inDrosophila melanogaster populations for mixed function oxidase activity and organophosphorus resistance was studied by sampling iso-chromosomal lines and laboratory selection. A 20-fold variation in malathion LC50 was found among a sample of 25 third chromosomes from a Raleigh, North Carolina, population. These chromosomes were combined in a population that was selected for malaoxon (a toxic metabolite of malathion) resistance over 12 generations. Response to selection was rapid—within three generations—but small, less than two-fold increase in malathion LC50. Mixed function oxidase activity, as assayed by 7-ethoxycoumarin-O-deethylase, increased in parallel with malathion resistance in the selected population. In spite of the fact that this population was initially formed from strains which were homozygous for chromosome III, after 12 generations of selection for malaoxon resistance only a minority of third chromosomes could be isolated as homozygous combinations. This suggests that selection favoured heterozygous combinations of alleles with decreased fitness in the homozygous state. In a second study, a sample of 39 iso-female lines were collected from a Vineland, Ontario, population. Imidan? (phosmet) LC50 varied 20-fold among these iso-female lines and was strongly correlated with increased 7-ethoxycoumarin-O-deethylase activity. The distribution of 7-ethoxycoumarin-O-deethylase activity was bimodal and estimates of the effective number of segregating factors by Wright’s formula were consistent with a single gene controlling extreme 7-ethoxycoumarin-O-deethylase activity differences. Vineland flies responded rapidly to selection for imidan resistance, but as with malaoxon selection only to a small degree. The 7-ethoxycoumarin-O-deethylase activity increased in imidan-selected flies to the level of the most resistant iso-female line from the sampled population. The major part of selected imidan resistance and all of the increased 7-ethoxycoumarin-O-deethylase activity were attributed to third chromosomal genes. The results suggest that theseDrosophila populations contained a polymorphism for a major factor on chromosome III controlling elevated mixed function oxidase activity together with associated organophosphorus resistance. This polymorphism provided the immediate response to insecticide selection. Other genes have minor effects and combine to give a multifactorial response to selection over longer periods of time. 相似文献
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David R. Mathog 《Development genes and evolution》1991,199(8):449-457
Summary
Drosophila melanogaster normally have six thoracic legs and no abdominal legs. However, one or two legs often appear in the first abdominal segment ofbithoraxoid mutants. The extent to which these extra legs develop is determined both by thecis-regulatory action ofbithoraxoid lesions onUltrabithorax and by the number of copies of the adjacent homeotic geneabdominal-A. Thebithoraxoid region does notcis-regulateabdominal-A. 相似文献
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K. Vijay Raghavan 《Development genes and evolution》1981,190(5):297-300
Summary Electrophoresis of myosin extracts from larvae and adult tissues ofDrosophila melanogaster under non-dissociating conditions indicate that two of the bands seen are myosins. They stain for Ca2+ ATPase activity and when cut and re-run under dissociating conditions are found to contain a myosin heavy chain that co-migrates with rabbit skeletal muscle myosin heavy chain. One of the forms of myosin seen is found primarily in extracts from the leg. The other is common to the adult fibrillar flight muscles and the larval body wall muscles.The electrophoretic evidence for two myosin types is strengthened by the histochemical demonstration of two myofibrillar ATPases on the basis of their lability to acid or alkali preincubation. The myofibrillar ATPase in the leg and the Tergal Depressor of the Trochanter (TDT) are shown to be relatively acid labile and alkali stable. The larval body wall muscles and the adult fibrillar flight muscles have an ATPase which is acid stable and alkali labile. This distribution of the two myofibrillar ATPase coincides with that predicted by electrophoresis of extracts from whole tissue and also locates the two myosins to specific muscle types. 相似文献
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Summary The influence of muscle development on thorax morphogenesis has been investigated inDrosophila melanogaster. The development of an indirect flight muscle, the dorsal longitudinal muscle (DLM), has been thought to be responsible for the formation of the distinct thoracic curvature. Using aDrosophila mutant (sr/Df(3)sr) in which the DLM is completely missing, we have shown that a normally curved thorax still is produced. Such results indicate that an external structure (epidermis) is capable of developing wholly independent of an absent internal structure (muscle). 相似文献
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During gametogenesis, chromosomes may become imprinted with information which facilitates proper expression of the DNA in offspring. We have used a position effect variegation mutant as a reporter system to investigate the possibility of imprinting inDrosophila melanogaster. Genetic crosses were performed in which the variegating gene and a strong modifier of variegation were present either within the same parental genome or in opposite parental genomes in all possible combinations. Our results indicate that the presence of the variegating chromosome and a modifier chromosome in the same parental genome can alter the amount of variegation formed in progeny. The genomic imprinting we observed is not determined by the parental origin of the variegating chromosome but is instead determined by the genetic background the variegating chromosome is subjected to during gametogenesis. 相似文献
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Morphology of transcription units inDrosophila melanogaster 总被引:1,自引:1,他引:0