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Structural Characterisation of Alkaloids in Leaves and Roots of Stephania kwangsiensis by LC‐QTOF‐MS 下载免费PDF全文
Yan Shangguan Jiayong He Yun Kang Yaqin Wang Ping Yang Jixian Guo Jianming Huang 《Phytochemical analysis : PCA》2018,29(1):101-111
Introduction
The tuberous roots of Stephania kwangsiensis, which contain bioactive alkaloids, are used as a traditional Chinese medicine. Overexploitation of the roots has made the plant increasingly rare, and the abundant leaves of the same plant may offer a potential alternative. However, there is insufficient phytochemical information for a comparison of alkaloid compositions in the two parts.Objective
To characterise and compare the alkaloids in the leaves and roots of S. kwangsiensis.Methods
The alkaloids in S. kwangsiensis were characterised using high pressure liquid chromatography coupled with positive electrospray ionisation quadrupole time‐of‐flight tandem mass spectrometry (HPLC‐(+)ESI‐QTOF‐MS/MS). The alkaloid compositions in the leaves and roots were compared by visual inspection combined with principal component analysis (PCA) of the HPLC‐MS data.Results
Seventy‐five alkaloids comprising aporphine‐, proaporphine‐, protoberberine‐, benzylisoquinoline‐, bisbenzylisoquinoline‐ and morphine‐type alkaloids were identified or tentatively identified in the roots and leaves of S. kwangsiensis. Sixty‐three of these alkaloids have not been previously reported in this species, and three have not been previously reported in the literature. The roots and leaves had similarities in alkaloid composition but differences in the peak intensities of most alkaloids. The PCA revealed that the samples were clustered into two distinct groups, which corresponded to leaves and roots.Conclusion
This study further clarified the chemical constituents in the roots of S. kwangsiensis, and revealed that diverse alkaloids were also present in the leaves. The comparative chemical profiling of the two parts provides useful information on their potential medicinal use. Copyright © 2017 John Wiley & Sons, Ltd. 相似文献7.
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LC‐MS‐based metabolite profiling of methanolic extracts from the medicinal and aromatic species Mentha pulegium and Origanum majorana 下载免费PDF全文
Amani Taamalli David Arráez‐Román Leila Abaza Ihsan Iswaldi Alberto Fernández‐Gutiérrez Mokhtar Zarrouk Antonio Segura‐Carretero 《Phytochemical analysis : PCA》2015,26(5):320-330
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Rapid identification of new minor chemical constituents from Smilacis Glabrae Rhizoma by combined use of UHPLC‐Q‐TOF‐MS,preparative HPLC and UHPLC‐SPE‐NMR‐MS techniques 下载免费PDF全文
Wan‐Yi Gu Na Li Elaine Lai‐Han Leung Hua Zhou Xiao‐Jun Yao Liang Liu Jian‐Lin Wu 《Phytochemical analysis : PCA》2015,26(6):428-435