共查询到20条相似文献,搜索用时 125 毫秒
1.
Background
Sequence periodicity with a period close to the DNA helical repeat is a very basic genomic property. This genomic feature was demonstrated for many prokaryotic genomes. The Escherichia coli sequences display the period close to 11 base pairs. 相似文献2.
Neil D Tsutsui Andrew V Suarez Joseph C Spagna J Spencer Johnston 《BMC evolutionary biology》2008,8(1):64
Background
Despite the economic and ecological importance of ants, genomic tools for this family (Formicidae) remain woefully scarce. Knowledge of genome size, for example, is a useful and necessary prerequisite for the development of many genomic resources, yet it has been reported for only one ant species (Solenopsis invicta), and the two published estimates for this species differ by 146.7 Mb (0.15 pg). 相似文献3.
Background
Biological studies involve a growing number of distinct high-throughput experiments to characterize samples of interest. There is a lack of methods to visualize these different genomic datasets in a versatile manner. In addition, genomic data analysis requires integrated visualization of experimental data along with constantly changing genomic annotation and statistical analyses. 相似文献4.
Background
The role of centrioles in mitotic spindle function remains unclear. One approach to investigate mitotic centriole function is to ask whether mutation of centriole-associated proteins can cause genomic instability. 相似文献5.
Maayan Amit Noa Sela Hadas Keren Ze'ev Melamed Inna Muler Noam Shomron Shai Izraeli Gil Ast 《BMC molecular biology》2007,8(1):109
Background
Gene duplication and exonization of intronic transposed elements are two mechanisms that enhance genomic diversity. We examined whether there is less selection against exonization of transposed elements in duplicated genes than in single-copy genes. 相似文献6.
Background
SRY is the pivotal gene initiating male sex determination in most mammals, but how its expression is regulated is still not understood. In this study we derived novel SRY 5' flanking genomic sequence data from bovine and caprine genomic BAC clones. 相似文献7.
Background
Pathogenicity islands (PAIs), distinct genomic segments of pathogens encoding virulence factors, represent a subgroup of genomic islands (GIs) that have been acquired by horizontal gene transfer event. Up to now, computational approaches for identifying PAIs have been focused on the detection of genomic regions which only differ from the rest of the genome in their base composition and codon usage. These approaches often lead to the identification of genomic islands, rather than PAIs. 相似文献8.
Background
Segmental duplications, or low-copy repeats, are common in mammalian genomes. In the human genome, most segmental duplications are mosaics comprised of multiple duplicated fragments. This complex genomic organization complicates analysis of the evolutionary history of these sequences. One model proposed to explain this mosaic patterns is a model of repeated aggregation and subsequent duplication of genomic sequences. 相似文献9.
Background
An important application of microarrays is to discover genomic biomarkers, among tens of thousands of genes assayed, for disease diagnosis and prognosis. Thus it is of interest to develop efficient statistical methods that can simultaneously identify important biomarkers from such high-throughput genomic data and construct appropriate classification rules. It is also of interest to develop methods for evaluation of classification performance and ranking of identified biomarkers. 相似文献10.
Maik?Grohmann Fabio?Spada Lothar?Schermelleh Natalia?Alenina Michael?Bader M?Cristina?Cardoso Heinrich?Leonhardt
Background
Mouse preimplantation development is characterized by both active and passive genomic demethylation. A short isoform of the prevalent maintenance DNA methyltransferase (Dnmt1S) is found in the cytoplasm of preimplantation embryos and transiently enters the nucleus only at the 8-cell stage. 相似文献11.
Background
The empirical frequencies of DNA k-mers in whole genome sequences provide an interesting perspective on genomic complexity, and the availability of large segments of genomic sequence from many organisms means that analysis of k-mers with non-trivial lengths is now possible. 相似文献12.
Chien-Hsing Lin Jen-Kou Lin Shih-Ching Chang Ya-Hui Chang Hwey-May Chang Jin-Hwang Liu Ling-Hui Li Yuan-Tsong Chen Shih-Feng Tsai Wei-Shone Chen 《Journal of biomedical science》2011,18(1):36
Background
Colorectal cancer (CRC) is a major health concern worldwide, and recently becomes the most common cancer in Asia. The case collection of this study is one of the largest sets of CRC in Asia, and serves as representative data for investigating genomic differences between ethnic populations. We took comprehensive and high-resolution approaches to compare the clinicopathologic and genomic profiles of microsatellite instability (MSI) vs. microsatellite stability (MSS) in Taiwanese sporadic CRCs. 相似文献13.
Background
The recent accumulation of closely related genomic sequences provides a valuable resource for the elucidation of the evolutionary histories of various organisms. However, although numerous alignment calculation and visualization tools have been developed to date, the analysis of complex genomic changes, such as large insertions, deletions, inversions, translocations and duplications, still presents certain difficulties. 相似文献14.
Background
Microarray-based comparative genome hybridization experiments generate data that can be mapped onto the genome. These data are interpreted more easily when represented graphically in a genomic context. 相似文献15.
Gregg A Helt John W Nicol Ed Erwin Eric Blossom Steven G Blanchard Stephen A Chervitz Cyrus Harmon Ann E Loraine 《BMC bioinformatics》2009,10(1):266
Background
Visualization software can expose previously undiscovered patterns in genomic data and advance biological science. 相似文献16.
17.
Carol A Edwards Willem Rens Oliver Clarke Andrew J Mungall Timothy Hore Jennifer A Marshall Graves Ian Dunham Anne C Ferguson-Smith Malcolm A Ferguson-Smith 《BMC evolutionary biology》2007,7(1):157
Background
The evolution of genomic imprinting, the parental-origin specific expression of genes, is the subject of much debate. There are several theories to account for how the mechanism evolved including the hypothesis that it was driven by the evolution of X-inactivation, or that it arose from an ancestrally imprinted chromosome. 相似文献18.
Background
Due to recent advances in whole genome shotgun sequencing and assembly technologies, the financial cost of decoding an organism's DNA has been drastically reduced, resulting in a recent explosion of genomic sequencing projects. This increase in related genomic data will allow for in depth studies of evolution in closely related species through multiple whole genome comparisons. 相似文献19.