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1.
Dynamics of binding between calcium and hydrophobic membrane components were investigated in vivo in identified neurons ofHelix pomatia while producing habituation to tactile stimuli using a fluorescent chlortetracycline probe technique. A decline in the concentration of membrane-bound calcium (Ca
b
2+
) and likewise in the intensity of electrophysiological response was found in the "command" neurons of defensive behavior when applying a train of stimuli. An increase in Ca
b
2+
was noted in the sensory neuron studied and in the spiracle motoneurons. It proved difficult to produce habituation in these cells fulfilling standard electrophysiological criteria. Hydrophobe-hydrophil transfer of calciumbinding molecules is thought to accompany production of habituation in nerve cells.P. K. Anokhin Institute of Normal Physiology, Academy of Medical Sciences of the USSR, Moscow. I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 21, No. 5, pp. 605–612, September–October, 1989. 相似文献
2.
A sensitizing treatment with 5–10% quinine solution causes short-term (lasting 50–70 min) and long-term (lasting several hours) changes in the activity of the command neurons for defensive behavior (LPl1 and PPl1) in the snailHelix lucorum. The short-term effects are characterized by a depolarizing shift in membrane potential, increased excitability, and an initial increase in the content of bound calcium (Ca-c) in the neurons. The long-term effects appear as facilitation of synaptic components of neuronal responses to sensory stimuli without any changes in excitability and in membrane potential, and also as a repeated increase of Ca-c content. Treatment with anisomycin or cycloheximide during sensitization acquirement prevents development of long-term sensitization.Translated from Neirofiziologiya, Vol. 25, No. 2, pp. 109–115, March–April, 1993. 相似文献
3.
I. V. Kudrashova 《Neurophysiology》1990,22(6):525-530
This study set out to investigate presynaptic mechanisms underlying reactivity of command neurons inHelix pomatia defensive behavior under the effects of desglycine-arginine vasopressin, a vasopressin analog. Peptide perfusion was found to intensify accumulated EPSP in command neurons during stimulation of the nerve without affecting the monosynaptic connection between primary sensory and command neurons. It was concluded that parallel pathways exist for the spread of excitation from the periphery to command neurons. Properties of such pathways are described and neurons with similar properties are identified. It is in these same cells that long-term changes in spontaneous EPSP induced by application of the peptide were noted.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 22, No. 6, pp. 723–730, November–December, 1990. 相似文献
4.
Neurophysiological effects and the dynamics of the content of bound calcium (Ca-b) in command neurons (LP1 and RP1) of defensive behavior during food aversion conditioning are studied inHelix lucorum. In the case of associative learning, there arises in these cells both a response to the conditioned stimulus and a nonspecific facilitation of the reactions to sensory stimuli that is characteristic for the state of sensitization. A response to the presentation of a conditioned stimulus is detected approximately 30 min after the development of long-term sensitization. The use of three or more paired stimuli reveals the characteristic dynamics of the level of Ca-b, which correlates with the neurophysiological effects and differs from the changes in Ca-b content during the development of "pure" sensitization. It is thought that the command neuron of defense behavior exhibits inHelix differences of the molecular-cellular mechanisms lying at the basis of the development of associative learning and sensitization.P. K. Anokhin Institute of Normal Physiology, Russian Academy of Sciences, Moscow. I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. Translated from Neirofiziologiya, Vol. 24, No. 6, pp. 691–701, November–December, 1992. 相似文献
5.
Spike activity was analyzed in the course of visual testing for directional sensitivity in 177 neuronal populations in different thalamic nuclei and the striopallidal complex in the brain of nine parkinsonian patients, diagnosed and treated using implanted intracerebral electrodes. Directionally selective neurons were discovered in the centrum medianum, the thalamic zona incerta and reticular nucleus, the caudate nucleus, and the central area of the globus pallidus. Proportions and distribution of neurons with different properties were investigated in the thalamic nuclei and striopallidal complex.Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 21, No. 5, pp. 652–660, September–October, 1989. 相似文献
6.
P. M. Balaban 《Neurophysiology》1987,19(3):230-235
The effects of serotonin on the amplitude of summated EPSP in interneurons and on the duration of action potentials in sensory neurons, interneurons, and motoneurons involved in avoidance behavior were investigated in functionally distinct neurons isolated from theHelix pomatia nervous system. The duration of action potentials in sensory neurons was found to increase under the effects of serotonin (and this could underly the rise in EPSP amplitude), although that of interneuron and motoneuron spikes did not change. The functional significance of selective neuronal response to a rise in serotonin concentration is discussed, together with the mechanics underlying such effects.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 19, No. 3, pp. 316–322, May–June, 1987. 相似文献
7.
Responses of single neurons in the lateral lobes of the medulla to stimulation of the electroreceptive system by homogeneous sinusoidal electrical and magnetic fields were investigated in acute experiments on the skateRaja radiata. Thresholds of neuronal responses to electrical stimulation varied from 0.03 to 10 µV/cm. The optimal frequency ranges for electrical and magnetic reception were in the regions of 0.05–5 and 2–3 Hz respectively. The possible mechanisms and functional significance of frequency characteristics of central neurons are discussed.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. All-Union Cardiologic Scientific Center, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 16, No. 4, pp. 464–470, July–August, 1984. 相似文献
8.
A classification was made of neuronal spike activity in the dorso- and ventromedial hypothalamic nuclei. Thermosensitive neurons in which response was accompanied by change in activity pattern could be identified with 0.95 probability by means of an algorithm based on this classification.I. V. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 20, No. 3, pp. 291–301, May–June, 1988. 相似文献
9.
A. G. Rabin 《Neurophysiology》1970,2(4):274-277
Fast fluctuations in the evoked potentials (EP) at a local point of the projection cortex following stimulation of different pathways may reflect the activity of pyramidal neurons of different cortical layers. Analysis shows that the afferent and interarea projections to the somatic sensory cortex terminate on different neurons which can be regarded as relay neurons for a given pathway. Each group of neurons has its own system of inhibition for selective control of impulses coming along this pathway at the cortical level.Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 2, No. 4, pp. 368–372, July–August, 1970. 相似文献
10.
The density of distribution of callosal neurons in the rabbit sensomotor cortex was studied by injecting horseradish peroxidase into the symmetrical region of the cortex. The degree of inequality of distribution of labeled neurons was determined visually and by statistical analysis. Stained callosal neurons were mainly small and medium-sized pyramidal cells, located chiefly in layer III–IV, and substantially less frequently in layers V and VI. Different forms of grouping of labeled neurons were observed in layer III–IV: two cells at a time, five to eight cells arranged vertically, or in concentrations, whose width was usually 120–200µ, and separated by areas with reduced density. The results are regarded as confirmation of those drawn previously from results of electrophysiological investigations on the modular organization of callosal connections in the rabbit sensomotor cortex.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Brain Institute, Academy of Medical Sciences of the USSR, Moscow. I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 16, No. 4, pp. 451–457, July–August, 1984. 相似文献
11.
The possible role of S-100 brain specific proteins and their involvement in the neuronal mechanisms of habituation were investigated in identified neurons of the snail (Helix pomatia). Extracellular application and intracellular injection of antibodies into S-100 proteins caused a rapid and significant reduction of neuronal response to repeated stimulation compared with the control. A considerable reduction in the amplitude of evoked EPSP and an increase in the duration of latency of potentials was produced by the antibodies and numbers of action potentials declined. Meanwhile, membrane potential, membrane input impedance, and neuronal pacemaker potentials remained virtually unchanged. This effect is presumed to occur due to breakdown of synaptic transmission processes. The subject of possible involvement of S-100 proteins in the operation of synaptic structures as a primary apparatus for integrating neuronal activity is considered.P. K. Anokhin Institute of Normal and Pathological Physiology, Academy of Medical Sciences of the USSR, Moscow; Institute of Physiology, University of Novi-Sad, SFRYu. Translated from Neirofiziologiya, Vol. 19, No. 5, pp. 637–645, September–October, 1987. 相似文献
12.
The site of action potential generation in unipolar snail neurons was identified by stimulating neurons isolated together with the initial portion of the process from the neuropile. Stimulation consisted of a sinusoidal from electrical current passed along the soma-axonal axis in saline solution. No low threshold sites of action potential generation were found in 80% of test neurons using this technique. Spontaneous activity was determined by the operation of one dominant site on the neuronal process. Antidromic activation of the soma by axonal action potentials (even with simultaneous hyperpolarization of the soma) induced somatic potentials more successfully than direct somatic depolarization by the current flowing through the solution.Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow. Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 20, No. 1, pp. 90–98, January–February, 1988. 相似文献
13.
Spontaneous and evoked synaptic activity of command neurons for the defensive response of spiracle closing were studied by simultaneous intracellular recording of activity of several identified CNS neurons in snails. Comparison of monosynaptic EPSPs in command neurons evoked by discharges of presynaptic neurons with spontaneous synaptic potentials indicated that the central organization of the defensive reflex is in the form of a two-layered neuron net in which each neuron of the afferent layer possesses a local receptive field, but which overlaps with other afferent neurons. Each neuron of the afferent layer is connected with each neuron of the efferent layer by monosynaptic excitatory connections that differ in efficiency (maximal only with one neuron of the efferent layer). Both receptive fields of neurons of the afferent layer and "fields of efficiency of synaptic connections" are distributed according to the normal law. As a result of this organization the neuron net acquires a new quality: The action of different stimuli leads to the appearance of differently located "spatial excitation profiles" of efferent layer neurons even when this action of the stimulus occurs not at the center of the receptive field.Institute of Higher Nervous Activity and Neurophysiology, Academy of Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 16, No. 1, pp. 26–34, January-February, 1984. 相似文献
14.
A study was made of brain neurite-stimulating proteins separated from lysosomal fractions of mammalian brain tissue. This protein stimulates axonal growth in sensory neurons in organotypic spinal ganglia culture. The physicochemical properties of neurite-stimulating protein differs from nerve growth factor — the familiar neurotrophic factor. Findings showed that nerve growth factor antiserum does not block the action of this protein. Accordingly, brain neuritestimulating protein separated in highly purified form was found to be a low molecular weight protein with the properties of nerve growth promoting factor. It can also be used in the study of conditions promoting sensory neuron ontogenesis and for stimulating regenerative processes within the nervous system.I. P. Kovlov Institute of Physiology, Academy of Sciences of the USSR, Leningrad. O. O. Zhdanov State University, Leningrad. Translated from Neirofiziologiya, Vol. 20, No. 1, pp. 15–20, January–February, 1988. 相似文献
15.
L. P. Dymnikova 《Neurophysiology》1991,23(5):425-429
Neuronal impulse activity in the thermoregulation center in the anterior and posterior sections of the rabbit hypothalamus was studied in chronic experiments and in intravenously injected anesthetics (urethane and chloralose). Anesthesia decreased the neuronal firing rate, changed the impulse activity pattern, and decreased the number of neurons responding to skin thermal stimulation. These changes were most pronounced in the posterior hypothalamic section.I. P. Pavlov Institute of Physiology, Academy of Sciences of the USSR, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 23, No. 5, pp. 574–579, September–October, 1991. 相似文献
16.
Neuronal activity was investigated in different thalamic nuclei and the striopallidal complex in parkinsonian patients with long-term implantation of intracerebral electrodes in the structures concerned for diagnostic and therapeutic purposes. Directionally selective neurons were found with consistent response to presentation of visual stimuli oriented at the same angle in a variety of (spatial) head positions differing by 90°.Institute of Experimental Medicine, Academy of Medical Sciences of the USSR, Leningrad. Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 21, No. 1, pp. 93–101, January–February, 1989. 相似文献
17.
It was found during experiments on rat sensory neurons that the relationship between high-threshold calcium channels and the system of intracellular cyclic nucleotide metabolism declined in the course of postnatal ontogenesis. Intracellullar administration of the cAMP-ATP-Mg2+ complex led to restoration after dialysis-induced decline in peak amplitude of high-threshold calcium currents in 70% of cells belonging to the first age group of 5–9-day-old animals, as against 26% of those examined in the 2nd (45-day-old) and only 10% of all those investigated in the third (90-day-old) group. Kinetics and voltage-dependence of high-threshold calcium current in the neuronal soma were identical in rats of all three age groups. The effect of recovery in calcium conductivity produced by intracellular application of the cAMP-ATP-Mg2+ complex was different in neurons with different inward current combinations. This recovery did not occur in cells with "fast" sodium and high-threshold calcium currents only. Conventional effects of intracellular cAMP application were seen in neurons mainfesting a "slow" TTX-resistant sodium inward current together with the two main inward currents.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Translated from Neirofiziologiya, Vo.. 18, No. 6, pp. 827–832, November–December, 1986. 相似文献
18.
S. N. Raeva A. O. Lukashev A. L. Kadin N. Ya. Vasin V. A. Shabalov N. P. Grokhovskii 《Neurophysiology》1990,22(4):330-336
Dynamics of neuronal interaction recorded by microelectrodes were examined in 90 arrays of cells of the human thalamic reticular nucleus (Rt) during stereotaxic surgical procedures. Cooperative interaction between adjacent neurons was found to occur in neuronal arrays after presentation of verbal (or sensory-cum-acoustic) functionally significant stimulus (FSS) as well as at stages of initiation and performance of goal-directed movement. Specialized dynamics were noted in the pattern of interaction between neuronal arrays of two types (A and B) with irregular background activity and 2–5 Hz bursting rhythm (types A and B respectively). This dynamic local neuronal interaction correlates with the stage of significant verbal stimulus presentation and that of performing goal-directed movements. The matching transient correlation between activity of A and B cell arrays reflects matching operation of two sequences of regulatory and control processes involved in processing of functionally significant verbal (or sensory) information and performance of goal-directed movement.Institute of Chemical Physics, Academy of Sciences of the USSR, Moscow Institute of Neurosurgery, Academy of Medical Sciences of the USSR, Moscow. Translated from Neirofiziologiya, Vol. 22, No. 4, pp. 451–459, June–July, 1990. 相似文献
19.
I. A. Vartanyan 《Neurophysiology》1975,7(6):466-470
Responses to frequency-modulated stimuli of 118 inferior collicular neurons were compared with quantitative characteristics of the frequency — threshold curves and lateral inhibitory zones during time-varying two-tone stimulation in anesthetized albino rats. In one third of neurons high sensitivity to the direction of frequency modulation does not correspond to their spatial characteristics (the shape, width, and arrangement of the lateral inhibitory zones relative to the frequency — threshold curve). The specificity of response of these neurons to a particular direction of frequency modulation is evidently based on differences in the temporal course of inhibition evoked by high-frequency and low-frequency tones.I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Academy of Sciences of the USSR, Leningrad. Translated from Neirofiziologiya, Vol. 7, No. 6, pp. 603–607, November–December, 1975. 相似文献
20.
The action of purified toxin from the sea anemoneHomostichanthus duerdemi (HTX-1) on the inward sodium current was studied in experiments on isolated neurons from rat spinal ganglia and neuroblastoma cells of clone N-18F1, by an intracellular perfusion and voltage clamp method. HTX-1 was found to delay inactivation of the tetrodotoxin-(TTX-)sensitive inward sodium current and to make it incomplete, but virtually without affecting its activation. The relationship between the fraction of sodium channels modified by the toxin and the HTX-1 concentration is described by a Langmuir isotherm with association constant of (1.1 ± 0.1)·10–7 M (holding potential –100 mV). Under the influence of the toxin the peak inward sodium current was increased by about 80%. Binding of HTX-1 with TTX-sensitive sodium channels is distinguished by strong potential-dependence: at a holding membrane potential of 0 mV the binding constant was an order of magnitude less than at a potential of –100 mV. In the case of brief action of HTX-1 on the nerve cell membrane (under 5 min) the effect of the toxin was completely reversible, but if the time of action of HTX-1 exceeded 30 min, subsequent washing with normal solution for 90 min did not abolish the effect completely.A. A. Bogomolets Institute of Physiology, Academy of Sciences of the Ukrainian SSR, Kiev. Pacific Institute of Bioorganic Chemistry, Far Eastern Scientific Center, Academy of Sciences of the USSR, Vladivostok. Translated from Neirofiziologiya, Vol. 14, No. 4, pp. 402–409, July–August, 1982. 相似文献