Structure of the RAF1-HSP90-CDC37 complex reveals the basis of RAF1 regulation

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Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division

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RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a “Kiss and Run” Mechanism

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Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

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HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

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Citrulline depletion by ASS1 is required for proinflammatory macrophage activation and immune responses

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ARAF protein kinase activates RAS by antagonizing its binding to RASGAP NF1

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Nde1 is a Rab9 effector for loading late endosomes to cytoplasmic dynein motor complex

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Polycomb Ezh1 maintains murine muscle stem cell quiescence through non-canonical regulation of Notch signaling

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The mTORC1-SLC4A7 axis stimulates bicarbonate import to enhance de novo nucleotide synthesis

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Oral feeding of nanoplastics affects brain function of mice by inducing macrophage IL-1 signal in the intestine

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SUMO Conjugation to BZR1 Enables Brassinosteroid Signaling to Integrate Environmental Cues to Shape Plant Growth

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Loss of TJP1 disrupts gastrulation patterning and increases differentiation toward the germ cell lineage in human pluripotent stem cells

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The evolutionarily conserved arginyltransferase 1 mediates a pVHL-independent oxygen-sensing pathway in mammalian cells

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Ubiquitination of phosphatidylethanolamine in organellar membranes

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Reticulon-3 Promotes Endosome Maturation at ER Membrane Contact Sites

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The E protein-TCF1 axis controls γδ T cell development and effector fate

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Gasdermin D maintains bone mass by rewiring the endo-lysosomal pathway of osteoclastic bone resorption

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The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region

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Chk1 promotes non-homologous end joining in G1 through direct phosphorylation of ASF1A

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