The E protein-TCF1 axis controls γδ T cell development and effector fate

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Reconstitution of the destruction complex defines roles of AXIN polymers and APC in β-catenin capture,phosphorylation, and ubiquitylation

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Highly multiplexed bioactivity screening reveals human and microbiota metabolome-GPCRome interactions

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Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration

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How insulin-like growth factor I binds to a hybrid insulin receptor type 1 insulin-like growth factor receptor

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Structural insights into assembly and function of GluN1-2C,GluN1-2A-2C,and GluN1-2D NMDARs

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Neurokinin-1 Receptor Signaling Is Required for Efficient Ca2+ Flux in T-Cell-Receptor-Activated T Cells

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Lyso-PAF,a biologically inactive phospholipid,contributes to RAF1 activation

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IL18 signaling causes islet β cell development and insulin secretion via different receptors on acinar and β cells

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Organ-specific COP1 control of BES1 stability adjusts plant growth patterns under shade or warmth

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Tet2 deficiency drives liver microbiome dysbiosis triggering Tc1 cell autoimmune hepatitis

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Effects on weight loss and glycemic control with SAR441255, a potent unimolecular peptide GLP-1/GIP/GCG receptor triagonist

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Follicular regulatory T cells produce neuritin to regulate B cells

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Ferroptosis surveillance independent of GPX4 and differentially regulated by sex hormones

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Transcriptional modification of host cells harboring Toxoplasma gondii bradyzoites prevents IFN gamma-mediated cell death

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Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

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Captured snapshots of PARP1 in the active state reveal the mechanics of PARP1 allostery

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An mTORC1-GRASP55 signaling axis controls unconventional secretion to reshape the extracellular proteome upon stress

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Divergent Roles for Macrophage C-type Lectin Receptors,Dectin-1 and Mannose Receptors,in the Intestinal Inflammatory Response

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