Systematic comparison of family history and polygenic risk across 24 common diseases

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BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection

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Structural and functional insights into the mechanism by which MutS2 recognizes a DNA junction

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Initiation of fibronectin fibrillogenesis is an enzyme-dependent process

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Sublethal cytochrome c release generates drug-tolerant persister cells

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An Oscillating MinD Protein Determines the Cellular Positioning of the Motility Machinery in Archaea

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Programmed Trade-offs in Protein Folding Networks

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Structural basis for product specificities of MLL family methyltransferases

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Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

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Site-Dependent Cysteine Lipidation Potentiates the Activation of Proapoptotic BAX

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A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing

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BOK controls apoptosis by Ca2+ transfer through ER-mitochondrial contact sites

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IPRO+/−: Computational Protein Design Tool Allowing for Insertions and Deletions

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ER-Golgi-localized proteins TMED2 and TMED10 control the formation of plasma membrane lipid nanodomains

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Structural insights into the functional divergence of WhiB-like proteins in Mycobacterium tuberculosis

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Structural study of the N-terminal domain of human MCM8/9 complex

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Vaccinia Virus Immunomodulator A46: Destructive Interactions with MAL and MyD88 Shown by Negative-Stain Electron Microscopy

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Structure of detergent-activated BAK dimers derived from the inert monomer

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Structures of sperm flagellar doublet microtubules expand the genetic spectrum of male infertility

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Fortuitous somatic mutations during antibody evolution endow broad neutralization against SARS-CoV-2 Omicron variants

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