共查询到20条相似文献,搜索用时 15 毫秒
1.
Jefferson EA Seth PP Robinson DE Winter DK Miyaji A Osgood SA Swayze EE Risen LM 《Bioorganic & medicinal chemistry letters》2004,14(20):5139-5143
A structure-activity relationship analysis was carried out on a high-throughput small molecule screening lead for HCV-IRES translation inhibition. The study led to the identification of a guanidine-based structure with low microM inhibitory activity. 相似文献
2.
Hiroaki Kato Mariko Kobayashi Kousaku Murata Takaaki Nishioka Jun’ichi Oda 《Bioscience, biotechnology, and biochemistry》2013,77(11):3071-3073
Kohamaic acid A is a potent DNA polymerase inhibitor isolated from the Okinawan marine sponge Ircinia sp. A series of structurally simplified analogs of kohamaic acid A were synthesized with the aim of evaluating structure-activity relationships. 相似文献
3.
Lee HY Jung Y Kim W Kim JH Suh MS Shin SK Yoon HJ 《Bioorganic & medicinal chemistry letters》2008,18(16):4670-4674
A series of Incentrom A analogs that inhibit the chromosome segregation process in yeast were synthesized and tested for their effects on chromosome stability and cell proliferation. Pharmacophore and structure-activity relationship of Incentrom A for the anti-yeast activity were established. 相似文献
4.
de Souza RO Barros JC da Silva JF Antunes OA 《Zeitschrift für Naturforschung. C, Journal of biosciences》2011,66(3-4):136-142
A quantitative structure-activity relationship model for Morita-Baylis-Hillman adducts with leishmanicidal activities was developed which correlates molecular orbital energy and dipole with percentage in the promastigote stage. 相似文献
5.
Lee DY He M Kondaveti L Liu-Chen LY Ma Z Wang Y Chen Y Li JG Beguin C Carlezon WA Cohen B 《Bioorganic & medicinal chemistry letters》2005,15(19):4169-4173
Salvinorin A is the most potent naturally occurring opioid agonist with a high selectivity and affinity for kappa-opioid receptor. To explore its structure-activity relationships, modifications at the C(4) position have been studied and a series of salvinorin A derivatives were prepared. These C(4)-modified salvinorin A analogues were screened for binding and functional activities at the human kappa-opioid receptor and several potent new agonists have been identified. 相似文献
6.
Yuhei Kinoshita Fumika Yakushiji Hidehito Matsui Hideaki Hanaki Satoshi Ichikawa 《Bioorganic & medicinal chemistry letters》2018,28(16):2713-2716
A structure-activity relationship study on three classes of polymyxin analogues focusing on hydrophobicity was conducted. 相似文献
7.
The inhibition of alcohol dehydrogenase in vitro and in isolated hepatocytes by 4-substituted pyrazoles 总被引:1,自引:0,他引:1
As a means of comparing the functional properties of an enzyme in dilute solution in vitro with those for the same enzyme acting in its normal cellular environment, a study was conducted with 4-substituted pyrazoles as inhibitors of rat liver alcohol dehydrogenase in vitro and ethanol oxidation in isolated rat hepatocytes. Inhibitor constants (Ki's) for the same set of pyrazole derivatives were also determined for human liver alcohol dehydrogenase. The best-fitting equations were derived to relate the Ki's to the chemical nature of substituents. These quantitative structure-activity relationships show that pyrazoles with stronger electron-withdrawing substituents are weaker inhibitors both for the enzyme in vitro and, to an equal extent, for ethanol oxidation by intact cells. Inhibitor effectiveness is also dependent on substituent hydrophobicity, but, while increasing hydrophobicity makes stronger inhibitors of the enzyme in vitro, it can diminish the effectiveness in vivo by decreasing permeability through the cell membrane. A structure-activity analysis of published Ki's for pyrazoles acting against human pi-ADH indicates that its active site differs from those in other alcohol dehydrogenases. 相似文献
8.
The structure-activity relationships of 63 adenosine analogs as agonists for the A1 adenosine receptors that mediate inhibition of adenylate cyclase activity in rat fat cells and for the A2 adenosine receptors that mediate stimulation of adenylate cyclase in rat pheochromocytoma PC12 cells and human platelets were determined. The lack of correspondence between the structure-activity relationships of these analogs at the A1 and A2 receptors appear definitive in terms of establishing the existence of A1 and A2 subclasses of adenosine receptors. However, significant differences in the agonist profiles at A2 receptors of platelet and PC12 indicate a certain degree of structural heterogeneity within the members of the A2 adenosine receptor subclass. Whether such differences are due to different species or different cell types is not known. A set of adenosine analogs, such as N6-cyclohexyl-, N6-R-, and S-1-phenyl-2- propyladenosines, 5'-N-ethylcarboxamidoadenosine and its N6-cyclohexyl derivative, 2-chloroadenosine, and 2-phenylaminoadenosine, appear to represent a series of analogs useful for pharmacological characterization of A1 and A2 classes of adenosine receptors. 相似文献
9.
Enrique M Arribas Julia Castro Ian R Clemens Juan C Cuevas Jesús Chicharro Ma Teresa Fraile Silvestre García-Ochoa Federico Gómez de las Heras José R Ruiz 《Bioorganic & medicinal chemistry letters》2002,12(2):117-120
A number of novel 3'-O-acyl and alkyl sordarins were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida albicans, Candida pseudotropicalis, Candida tropicalis and Cryptococcus neoformans. 相似文献
10.
Hjelmgaard T Persson T Rasmussen TB Givskov M Nielsen J 《Bioorganic & medicinal chemistry》2003,11(15):3261-3271
The synthesis of 5- and 3-(1'-hydroxyalkyl)-substituted 5H-furan-2-ones 4a-d and 8a-d as well as 5-alkylidene-5H-furan-2-ones 5a-d is described. A study of the structure-activity relationship of these furanone-based natural product analogues towards two different quorum sensing systems is reported. Although the synthesized compounds are not as potent quorum sensing inhibitors as some natural counterparts and a synthetic analogue hereof, interesting structure-activity relationships are seen. 相似文献
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Qiu WW Xu J Liu DZ Li JY Ye Y Zhu XZ Li J Nan FJ 《Bioorganic & medicinal chemistry letters》2006,16(12):3306-3309
A trifunctional probe (binding element-photoreactive group-affinity tag) of natural product paeoniflorin was designed and synthesized based on the previous primary structure-activity relationship. This new probe is a potential tool for labeling, purification, and identification of the target proteins. 相似文献
13.
A series of derivatives of bakuchiol were synthesized and tested in vitro for their cytotoxicity, and inhibition of T cell proliferation and B cell proliferation. The data obtained provided preliminary structure-activity relationships of the compounds as immunosuppressive activity. 相似文献
14.
目的:建立A型肉毒毒素抑制剂的定量构效关系模型。方法:应用分子全息定量构效关系(HQSAR)技术,研究了14种A型肉毒毒素抑制剂的抑制活性与其二维分子结构之间的关系,讨论了碎片区分参数及碎片长度对模型质量的影响。结果:最佳全息条件下产生的模型相关系数r2为0.780,交叉验证相关系数q2LOO为0.583。所建模型具有良好的拟和效果和较高的预测能力,HQSAR模型贡献图显示抑制剂分子中的噻吩环及羟胺对活性有较大贡献。结论:本研究对新抑制剂的设计具有一定的指导作用。 相似文献
15.
Alanine A Anselm L Steward L Thomi S Vifian W Groaning MD 《Bioorganic & medicinal chemistry letters》2004,14(3):817-821
The synthesis and in vitro structure-activity relationships (SAR) of a series of triazoles as A(2A) receptor antagonists is reported. This resulted in the identification of potent, selective and permeable 1,2,4-triazoles such as 42 for further optimization and evaluation in vivo. 相似文献
16.
José M Bueno Juan C Cuevas José M Fiandor Silvestre García-Ochoa Federico Gómez de las Heras 《Bioorganic & medicinal chemistry letters》2002,12(2):121-124
A number of novel 3',4'-fused dioxolane and dioxane sordarin derivatives were synthesised for structure-activity relationship studies. Many of these derivatives exhibit high activity against Candida spp. and Cryptococcus neoformans. 相似文献
17.
Structure-activity relationships of untenone A and its derivatives for inhibition of DNA polymerases
Saito F Takeuchi R Kamino T Kuramochi K Sugawara F Sakaguchi K Kobayashi S 《Bioorganic & medicinal chemistry letters》2004,14(8):1975-1977
We found that untenone A and mannzamenone A inhibit mammalian DNA polymerases alpha and beta, and human terminal deoxynucleotidyl transferase (TdT). The syntheses of both compounds and the structure-activity relationships of untenone A derivatives are described. 相似文献
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Zhang R Wang A DeAngelis A Pelton P Xu J Zhu P Zhou L Demarest K Murray WV Kuo GH 《Bioorganic & medicinal chemistry letters》2007,17(14):3855-3859
A novel series of potent and selective PPARdelta agonists, para-alkylthiophenoxyacetic acids, was identified. The synthesis and structure-activity relationships are described. 相似文献
20.
A variety of synthetic and natural polyphenols protect mammalian cells from hydrogen peroxide (H2O2). Cytotoxicity of H2O2 on Chinese hamster V79 cells was assessed with a colony formation assay, and several polyphenols prevented the decrease in the number of colonies caused by H2O2. A study of the structure-activity relationship revealed that affinity of the polyphenols for the cell membrane and the presence of an ortho-dihydroxy moiety in their structure proved essential to this protection. 相似文献