Acute promyelocytic leukemia with unusual karyotype

Acute myeloid leukemia (AML-M3) is associated with the translocation t(15;17)(q22;q12-21) which disrupts the retinoic acid receptor alpha (RARA) gene on chromosome 17 and the PML gene on chromosome 15. We report a two-year-old patient with AML-M3 without the usual translocation t(15;17). Cytogenetic studies demonstrated normal appearance of chromosome 15 while the abnormal 17 homologue was apparently a derivative 17, der(17)(17qter-cen-q21:), the rearrangement distinctly shows deletion at 17q21 band and the morphology corresponding to an iso chromosome i(17q-). This case report is a rare cytogenetic presentation of acute promyelocytic leukemia (APML).     

Adult T-cell leukemia with an unusual phenotype, Leu-2a positive and Leu-3a negative

A case of adult T-cell leukemia (ATL) with an unusual phenotype is presented. Leukemia cells of this patient reacted with anti-Leu-2a monoclonal antibody, although most of ATL cases are reported to show the phenotype of helper/inducer T-cell. It is indicated that the surface phenotype of ATL is rather heterogeneous.     

髓源性防御素的研究进展

防御素是一组含有6个半胱氨酸的阳离子抗微生物多肽。在中性粒细胞内,防御素含量丰富,具有广谱、高效的抗微生物活性,是机体天然免疫机制的重要组成部分。近年来的临床观察表明,测定血浆及各种体液中髓源性防御素的改变有助于某些炎症性疾患的诊断。此外,提纯或重组防御素作为“超级抗生素”则已成为药学界的研究热点。本文着重对髓源性防御素的生化特性、生物学活性及其与疾病的关系作一概述。     

Myeloid leukemia in male RFM mice following irradiation with fission spectrum neutrons or gamma rays

The induction of myeloid leukemia following fission neutron irradiation was examined over the 0-80 rad dose range. Over this dose range the dose response could be described by the linear regression equation: y = 0.94 + 0.18X. A comparison of these data with data obtained following gamma irradiation from this study and a previous study indicated that the relative biological effectiveness for myeloid leukemia induction was 2.8. These results appear to be compatible with those reported by other investigators.