Pavlov and the Rockefeller Foundation

Despite the tension between the United States and the Soviet Union in the early 1920's, the Rockefeller Foundation and the Rockefeller Institute for Medical Research found ways to assist I.P. Pavlov. In addition to providing scientific literature and financial aid, these institutions and their officers rendered important moral support to the scientific career of Pavlov during his later years. In 1923, as a guest of the Rockefeller Institute, Pavlov visited American scientific laboratories. In 1924, he requested and received a number of books on physiology, and during the 1930's the Foundation helped him to acquire equipment for his Leningrad laboratory.     

Pavlov and integrative physiology

Ivan Petrovich Pavlov was the first physiologist to win the Nobel Prize. The Prize was given in 1904 for his research on the neural control of salivary, gastric, and pancreatic secretion. A major reason for the success and novelty of his research was the use of unanesthetized dogs surgically prepared with chronic fistulas or gastric pouches that permitted repeated experiments in the same animal for months. Pavlov invented this chronic method because of the limitations he perceived in the use of acute anesthetized animals for investigating physiological systems. By introducing the chronic method and by showing its experimental advantages, Pavlov founded modern integrative physiology. This paper reviews Pavlov's journey from his birthplace in a provincial village in Russia to Stockholm to receive the Prize. It begins with childhood influences, describes his training and mentors, summarizes the major points of his research by reviewing his book Lectures on the Work of the Digestive Glands, and discusses his views on the relationship between physiology and medicine.     

Pavlov and the Nobel Prize Award

When Pavlov was first nominated for the Nobel Prize, he was well recognized by physiologists, especially those concerned with digestion. It appears unlikely that psychological interpretations of his conditional reflex findings had begun to penetrate deeply into the discipline of psychology. The selection in 1904 of Pavlov for the award in physiology or medicine attracted the attention of a broader range of scientists. American psychologists, in particular, probably became more aware of the advantages of incorporating his "objective" conditional reflex method into their investigations. General biographical aspects relating to the award and the effect of the award upon the acceptance of the conditional reflex method by American psychologists are developed in this presentation.     

Pavlov, psychoanalysis, and neuroses

Pavlov's discovery of experiment neurosis was serendipitous, yet it was made under the influence of Breuer and Freud's case of Anna O. In 1914, Pavlov's disciple N. R. Shenger-Krestovnikova, exploring the limits of visual discrimination in dogs, noticed that when the discrimination was difficult, the dogs' behavior became disorganized. Pavlov drew an analogy between the condition of Shenger-Krestovnikova's dogs and their disorganized behavior with Anna O.'s situation and her neurotic reaction. Pavlov concluded that he had demonstrated in the laboratory the elements of neurosis in animals and human alike. Schilder's criticism of his position, his later study of human neuroses in clinical settings, and the views of Janet may have induced Pavlov to differentiate between animal and human neuroses.     

Pavlov and psychophysiology in the 21st century]

Psychophysiology, physiological psychology (Sechenov), human physiology of higher nervous activity (Pavlov) is an interdisciplinary field, which appeared at the interface between psychology and neurosciences for exploration of the brain mechanisms of mental functions. The fundamental complementation of subjective and objective, psychological and neurobiological approaches as the facets of investigation of the basically whole process made it possible to fill with a specific content and clearly differentiate the forms of human psyche such as emotion, consciousness, personality, character, and creativity.     

I. P. Pavlov and the development of neuroscience

Ivan Petrovitch Pavlov significantly changed and developed our knowledge of the brain functions and of the behaviour by his fundamental experimental and theoretical work on the physiology and pathophysiology of the higher nervous activity. He was one of the scientists who prepared the development of neuroscience in our century. During the Pavlovian Conference, 1950 in Moscow Stalin and the Communist Party tried to dogmatize his and his pupil's fundamental theories. But his pupils continued to develop Pavlovian ideas in open discussions with representatives of other schools in a very creative way, opening the doors for a system approach to understand the integrative functional systems of brain and behavior. Pavlov emphasized the high plasticity of the central nervous system. He investigated the complex functional systems within the brain and between the organism and its environment, and the designed models for pathology of the higher nervous activity. During his last years, Pavlov freed himself from the strong deterministic view and characterized the organism and its environment as a self-organizing system.     

Assessing the degree of association in groups of animals using the concept of entropy

Nearest-neighbour analysis is commonly used to calculate indices of aggregation in groups of animals. It has several problems, however, including lack of data independence and, when studying groups of animals penned at high densities, the difficulty of determining a given individual's nearest neighbour. We describe an entropy-based method to assess the degree of association (or segregation) of groups of animals. We show that this method gives more information and is more sensitive than the nearest-neighbour technique. An example with a particular experimental situation (mixing groups of lambs) is presented. Copyright 2000 The Association for the Study of Animal Behaviour.     

Definition of the rheological glass transition temperature in association with the concept of iso-free-volume

Small deformation dynamic oscillation was used to develop an index of physical significance for the rationalisation of the mechanical properties of high co-solute/biopolymer systems during vitrification. The index is based on the combined framework of Williams–Landel–Ferry equation with the free volume theory and is called the ‘rheological glass transition temperature, T_g’ thus differentiating it from the empirical calorimetric T_g used in thermal analysis. The rheological T_g is located at the conjunction of two distinct molecular processes, namely: free-volume effects in the glass transition region and the predictions of the reaction-rate theory in the glassy state. The method of reduced variables was used to shift the mechanical spectra of shear moduli to composite curves. The temperature dependence of shift factors for all materials was identical provided that they were normalised at suitably different reference temperatures, which reflect iso-free-volume states. The treatment makes free volume the overriding parameter governing the mechanical relaxation times during vitrification of high co-solute/biopolymer systems regardless of physicochemical characteristics. We believe that potential applications resulting from this fundamental work are numerous for the food and pharmaceutical industries.     

Gantt, Pavlov and Freud: a comparison

Contrasts between classical Pavlovianism and classical psychoanalysis have been emphasized, but there are also significant similarities of which I write. A recent edition of a textbook of psychiatry which is widely used in the United States (Kaplan and Sadock 1985) indexes neither Pavlov nor Gantt, although it provides extensive coverage of psychoanalysis.