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Genetical genomics: the added value from segregation. 总被引:39,自引:0,他引:39
The recent successes of genome-wide expression profiling in biology tend to overlook the power of genetics. We here propose a merger of genomics and genetics into 'genetical genomics'. This involves expression profiling and marker-based fingerprinting of each individual of a segregating population, and exploits all the statistical tools used in the analysis of quantitative trait loci. Genetical genomics will combine the power of two different worlds in a way that is likely to become instrumental in the further unravelling of metabolic, regulatory and developmental pathways. 相似文献
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ABSTRACT: The genome sequence of tomato (Solanum lycopersicum), one of the most important vegetable crops, has recently been decoded. We address implications of the tomato genome for plant breeding, genomics and evolutionary studies, and its potential to fuel future crop biology research. 相似文献
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This comprehensive volume brings together the expertise of internationallyacclaimed experts in the areas of quantitative genetics, genomicsand bioinformatics, applied to improve crops performanceand to further our understanding of the intricacies of the genotypeby environment (G x E) interaction. The complexity of the subjectarea dealt with by the book has been masterfully dissected andskillfully presented in a number of revealing chapters, providingthe 相似文献
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Hughes S 《Plant biotechnology journal》2006,4(1):3-5
Recent report reviews and funding initiatives in the field of plant genomic research are considered in the context of their translation into practical and economic value via plant breeding. It is concluded that there is a deficit in investment and that a change in working styles towards knowledge sharing and connectivity is required. 相似文献
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Romanov Michael N Tuttle Elaina M Houck Marlys L Modi William S Chemnick Leona G Korody Marisa L Mork Emily M Stremel Otten Christie A Renner Tanya Jones Kenneth C Dandekar Sugandha Papp Jeanette C Da Yang Green Eric D Magrini Vincent Hickenbotham Matthew T Glasscock Jarret McGrath Sean Mardis Elaine R Ryder Oliver A 《BMC genomics》2009,10(2):1-4
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Michael N Romanov Elaina M Tuttle Marlys L Houck William S Modi Leona G Chemnick Marisa L Korody Emily M Stremel Mork Christie A Otten Tanya Renner Kenneth C Jones Sugandha Dandekar Jeanette C Papp Yang Da NISC Comparative Sequencing Program Eric D Green Vincent Magrini Matthew T Hickenbotham Jarret Glasscock Sean McGrath Elaine R Mardis Oliver A Ryder 《BMC genomics》2009,10(Z2):S10
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Meyers-Wallen VN 《Theriogenology》2006,66(6-7):1655-1658
The genomic revolution is beginning to facilitate advances in canine and feline medicine, as illustrated in our research. Our studies are focused upon identifying the gene mutation that causes canine Sry-negative XX sex reversal, a disorder of sex determination in which chromosomal females (78,XX) develop testicular tissue, becoming either XX true hermaphrodites with ovotestes, or XX males with bilateral testes. A genome-wide screen, using mapped markers in our pedigree of Sry-negative XX sex reversed dogs founded upon the American cocker spaniel, identified five chromosomal regions in which the causative gene may be located. The canine genome was used to identify the canine homologue of goat Pisrt1 and so determine that canine and caprine Sry-negative XX sex reversal are genetically heterogeneous. A second goal of our research is to determine the molecular mechanism by which the mutation causes testis induction. Thus far, we have reported gonadal Sry and Sox9 expression patterns in normal embryos, which have temporal and spatial patterns similar to those reported in humans, sheep, and pigs. Once gene mutations causing such inherited disorders are identified, DNA tests will become a part of general veterinary practice, advancing both diagnostic techniques and preventative medicine. 相似文献