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Highlights? Constitutively increasing Cdc42 activity causes aging of young HSCs ? Elevated Cdc42 activity correlates with a loss of cell polarity in aged HSCs ? Inhibition of Cdc42 activity rejuvenates aged LT-HSC function ? Cdc42 inhibition restores the level and spatial distribution of AcH4K16  相似文献   

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Highlights? Self-organization is a property of developmental systems and pluripotent stem cells. ? Tissue engineering approaches can be applied to control self-organization in vitro. ? Maturation of pluripotent stem cells in vitro may be promoted by self-organization. ? Subtle, dynamic signals are provided to pluripotent cells through self-organization.  相似文献   

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Reconstructing stem cell niches via droplet microfluidic technology.
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