共查询到20条相似文献,搜索用时 31 毫秒
1.
Involvement of novel human immunodeficiency virus type 1 reverse transcriptase mutations in the regulation of resistance to nucleoside inhibitors 总被引:4,自引:0,他引:4
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Svicher V Sing T Santoro MM Forbici F Rodríguez-Barrios F Bertoli A Beerenwinkel N Bellocchi MC Gago F d'Arminio Monforte A Antinori A Lengauer T Ceccherini-Silberstein F Perno CF 《Journal of virology》2006,80(14):7186-7198
2.
Quantification of the effects on viral DNA synthesis of reverse transcriptase mutations conferring human immunodeficiency virus type 1 resistance to nucleoside analogues
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Bouchonnet F Dam E Mammano F de Soultrait V Henneré G Benech H Clavel F Hance AJ 《Journal of virology》2005,79(2):812-822
3.
4.
Pérez CL Larsen MV Gustafsson R Norström MM Atlas A Nixon DF Nielsen M Lund O Karlsson AC 《Journal of immunology (Baltimore, Md. : 1950)》2008,180(7):5092-5100
The genetic variations of the HIV-1 virus and its human host constitute major obstacles for obtaining potent HIV-1-specific CTL responses in individuals of diverse ethnic backgrounds infected with different HIV-1 variants. In this study, we developed and used a novel algorithm to select 184 predicted epitopes representing seven different HLA class I supertypes that together constitute a broad coverage of the different HIV-1 strains as well as the human HLA alleles. Of the tested 184 HLA class I-restricted epitopes, 114 were recognized by at least one study subject, and 45 were novel epitopes, not previously described in the HIV-1 immunology database. In addition, we identified 21 "elite" epitopes that induced CTL responses in at least 4 of the 31 patients. A majority (27 of 31) of the study population recognized one or more of these highly immunogenic epitopes. We also found a limited set of 9 epitopes that together induced HIV-1-specific CTL responses in all HIV-1-responsive patients in this study. Our results have important implications for the validation of potent CTL responses and show that the goal for a vaccine candidate in inducing broadly reactive CTL immune responses is attainable. 相似文献
5.
Selection of mutations in the connection and RNase H domains of human immunodeficiency virus type 1 reverse transcriptase that increase resistance to 3'-azido-3'-dideoxythymidine 总被引:1,自引:0,他引:1
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Brehm JH Koontz D Meteer JD Pathak V Sluis-Cremer N Mellors JW 《Journal of virology》2007,81(15):7852-7859
6.
Knoepfel SA Salisch NC Huelsmann PM Rauch P Walter H Metzner KJ 《Journal of virology》2008,82(13):6536-6545
7.
8.
Crystal structures of Zidovudine- or Lamivudine-resistant human immunodeficiency virus type 1 reverse transcriptases containing mutations at codons 41, 184, and 215 总被引:6,自引:0,他引:6
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Chamberlain PP Ren J Nichols CE Douglas L Lennerstrand J Larder BA Stuart DI Stammers DK 《Journal of virology》2002,76(19):10015-10019
9.
Resistant variants were selected in vitro against two novel nucleoside analogues, (+) dOTC and (-) dOTFC using the HIV-1 molecular clone HXB2D. The variants obtained displayed 6.5-fold and 10-fold resistance to these compounds, respectively. Cloning and sequencing of the RT genes of the selected viruses identified two mutations, M184I for (+) dOTC and M184V for (-) dOTFC. Results with mutated recombinant clones of HXB2D confirmed the importance of these mutations in MT-4 cells. The resistance profiles of clinical samples with wild-type or 3TC-resistant phenotypes were also studied; low to moderate levels of cross-resistance were observed against the novel compounds. 相似文献
10.
11.
Mason RD Bowmer MI Howley CM Gallant M Myers JC Grant MD 《Journal of immunology (Baltimore, Md. : 1950)》2004,172(11):7212-7219
Antiretroviral drug resistance and escape from CTL are major obstacles to effective control of HIV replication. To investigate the possibility of combining drug and immune-based selective pressures against HIV, we studied the effects of antiretroviral drug resistance mutations on CTL recognition of five HIV-1 Pol epitopes presented by common HLA molecules. We found that these common drug resistance mutations sustain or even enhance the antigenicity and immunogenicity of HIV-1 Pol CTL epitopes. Variable patterns of cross-reactive and selective recognition of wild-type and corresponding variant epitopes demonstrate a relatively diverse population of CD8(+) T cells reactive against these epitopes. Variant peptides with multiple drug resistance mutations still sustained CTL recognition, and some HIV-infected individuals demonstrated strong CD8(+) T cell responses against multiple CTL epitopes incorporating drug resistance mutations. Selective reactivity against variant peptides with drug resistance mutations reflected ongoing or previous exposure to the indicated drug, but was not dependent upon the predominance of the mutated sequence in endogenous virus. The frequency and diversity of CTL reactivity against the variant peptides incorporating drug resistance mutations and the ability of these peptides to activate and expand CTL precursors in vitro indicate a significant functional interface between the immune system and antiretroviral therapy. Thus, drug-resistant variants of HIV are susceptible to immune selective pressure that could be applied to combat transmission or emergence of antiretroviral drug-resistant HIV strains and to enhance the immune response against HIV. 相似文献
12.
13.
Nathalie Richard Horacio Salomon Maureen Oliveira Robert Rando Mark A. Wainberg 《Nucleosides, nucleotides & nucleic acids》2013,32(4-5):773-778
Abstract Resistant variants were selected in vitro against two novel nucleoside analogues, (+) dOTC and (-) dOTFC using the HIV-1 molecular clone HXB2D. The variants obtained displayed 6.5-fold and 10-fold resistance to these compounds, respectively. Cloning and sequencing of the RT genes of the selected viruses identified two mutations, M184I for (+) dOTC and M184V for (-) dOTFC. Results with mutated recombinant clones of HXB2D confirmed the importance of these mutations in MT-4 cells. The resistance profiles of clinical samples with wild-type or 3TC-resistant phenotypes were also studied; low to moderate levels of cross-resistance were observed against the novel compounds. 相似文献
14.
15.
Clustering patterns of cytotoxic T-lymphocyte epitopes in human immunodeficiency virus type 1 (HIV-1) proteins reveal imprints of immune evasion on HIV-1 global variation 总被引:7,自引:0,他引:7
下载免费PDF全文
![点击此处可从《Journal of virology》网站下载免费的PDF全文](/ch/ext_images/free.gif)
Yusim K Kesmir C Gaschen B Addo MM Altfeld M Brunak S Chigaev A Detours V Korber BT 《Journal of virology》2002,76(17):8757-8768
16.
17.
Violin M Forbici F Cozzi-Lepri A Velleca R Bertoli A Riva C Giannella S Manconi PE Lazzarin A Pasquinucci S Tacconi L Carnevale G Mazzotta F Bonazzi L Montroni M Chirianni A Capobianchi M Ippolito G Moroni M Perno CF D'Arminio-Monforte A;I.CO.N.A. Study Group. Italian Cohort of Antiretroviral Naive patients 《Journal of biological regulators and homeostatic agents》2002,16(1):37-43
18.
19.