共查询到20条相似文献,搜索用时 15 毫秒
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Glycogen synthase kinase 3beta (GSK3beta) regulates differentiation and proliferation in neural stem cells from the rat subventricular zone 总被引:1,自引:0,他引:1
Maurer MH Brömme JO Feldmann RE Järve A Sabouri F Bürgers HF Schelshorn DW Krüger C Schneider A Kuschinsky W 《Journal of proteome research》2007,6(3):1198-1208
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Yongliang Zhang Kristi L. Helke Sergio G. Coelho Julio C. Valencia Vincent J. Hearing Shaoli Sun Bei Liu Zihai Li 《Pigment cell & melanoma research》2014,27(1):82-89
Through a process known as melanogenesis, melanocyte produces melanin in specialized organelles termed melanosomes, which regulates pigmentation of the skin, eyes, and hair. Gp96 is a constitutively expressed heat shock protein in the endoplasmic reticulum whose expression is further upregulated upon ultraviolet irradiation. However, the roles and mechanisms of this chaperone in pigmentation biology are unknown. In this study, we found that knockdown of gp96 by RNA interference significantly perturbed melanin synthesis and blocked late melanosome maturation. Gp96 knockdown did not impair the expression of tyrosinase, an essential enzyme in melanin synthesis, but compromised its catalytic activity and melanosome translocation. Further, mice with melanocyte‐specific deletion of gp96 displayed decreased pigmentation. A mechanistic study revealed that the defect in melanogenesis can be rescued by activation of the canonical Wnt pathway, consistent with the critical roles of gp96 in chaperoning Wnt‐coreceptor LRP6. Thus, this work uncovered the essential role of gp96 in regulating melanogenesis. 相似文献
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Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling 总被引:4,自引:0,他引:4
Choi H Ahn S Lee BG Chang I Hwang JS 《Pigment cell research / sponsored by the European Society for Pigment Cell Research and the International Pigment Cell Society》2005,18(6):439-446
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