共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
Wnt/β‐Catenin Signaling Activates Expression of the Bone‐Related Transcription Factor RUNX2 in Select Human Osteosarcoma Cell Types 下载免费PDF全文
Oscar A. Vega Claudia M.J. Lucero Hector F. Araya Sofia Jerez Julio C. Tapia Marcelo Antonelli Flavio Salazar‐Onfray Facundo Las Heras Roman Thaler Scott M. Riester Gary S. Stein Andre J. van Wijnen Mario A. Galindo 《Journal of cellular biochemistry》2017,118(11):3662-3674
3.
4.
5.
6.
Progeny From Irradiated Colorectal Cancer Cells Acquire an EMT‐Like Phenotype and Activate Wnt/β‐Catenin Pathway 下载免费PDF全文
Lilian Gonçalves dos Reis Bastos Priscila Guimarães de Marcondes Julio Cesar Madureira de‐Freitas‐Junior Fernanda Leve André Luiz Mencalha Waldemir Fernandes de Souza Wallace Martins de Araujo Marcelo Neves Tanaka Eliana Saul Furquim Werneck Abdelhay José Andrés Morgado‐Díaz 《Journal of cellular biochemistry》2014,115(12):2175-2187
7.
Therapeutic Potential of Targeting Wnt/β‐Catenin Pathway in Treatment of Colorectal Cancer: Rational and Progress 下载免费PDF全文
Afsane Bahrami Forouzan Amerizadeh Soodabeh ShahidSales Majid Khazaei Majid Ghayour‐Mobarhan Hamid Reza Sadeghnia Mina Maftouh Seyed Mahdi Hassanian Amir Avan 《Journal of cellular biochemistry》2017,118(8):1979-1983
8.
9.
10.
11.
IRS1/β‐Catenin Axis Is Activated and Induces MYC Expression in Acute Lymphoblastic Leukemia Cells 下载免费PDF全文
Jaqueline Cristina Fernandes Ana Paula Nunes Rodrigues Alves João Agostinho Machado‐Neto Renata Scopim‐Ribeiro Bruna Alves Fenerich Fernanda Borges da Silva Belinda Pinto Simões Eduardo Magalhães Rego Fabiola Traina 《Journal of cellular biochemistry》2017,118(7):1774-1781
12.
Mei‐Ying Shao Ran Cheng Feng‐Ming Wang Hui Yang Li Cheng Tao Hu 《Cell biology international》2011,35(2):105-109
TGF‐β1 (transforming growth factor‐β1) plays a central role in regulating proliferation, migration and differentiation of dental pulp cells during the repair process after tooth injury. Our previous study showed that p38 mitogen‐activated protein kinase may act downstream of TGF‐β1 signalling to effect the differentiation of dental pulp cells. However, the molecular mechanisms that trigger and regulate the process remain to be elucidated. TGF‐β1 interacts with signalling pathways such as Wnt/β‐catenin and Rho to induce diverse biological effects. TGF‐β1 activates β‐catenin signalling, increases β‐catenin nuclear translocation and interacts with LEF/TCF to regulate gene expression. Morphologic changes in response to TGF‐β1 are associated with activation of Rho GTPases, but are abrogated by inhibitors of Rho‐associated kinase, a major downstream target of Rho. These results suggest that the Wnt/β‐catenin and Rho pathways may mediate the downstream events of TGF‐β1 signalling. 相似文献
13.
14.
RAR‐Related Orphan Receptor Gamma (ROR‐γ) Mediates Epithelial‐Mesenchymal Transition Of Hepatocytes During Hepatic Fibrosis 下载免费PDF全文
Sung Min Kim Jung Eun Choi Wonhee Hur Jung‐Hee Kim Sung Woo Hong Eun Byul Lee Joon Ho Lee Tian Zhu Li Pil Soo Sung Seung Kew Yoon 《Journal of cellular biochemistry》2017,118(8):2026-2036
The epithelial‐mesenchymal transition (EMT) is involved in many different types of cellular behavior, including liver fibrosis. In this report, we studied a novel function of RAR‐related orphan receptor gamma (ROR‐γ) in hepatocyte EMT during liver fibrosis. To induce EMT in vitro, primary hepatocytes and FL83B cells were treated with TGF‐β1. Expression of ROR‐γ was analyzed by Western blot in the fibrotic mouse livers and human livers with cirrhosis. To verify the role of ROR‐γ in hepatocyte EMT, we silenced ROR‐γ in FL83B cells using a lentiviral short hairpin RNA (shRNA) vector. The therapeutic effect of ROR‐γ silencing was investigated in a mouse model of TAA‐induced fibrosis by hydrodynamic injection of plasmids. ROR‐γ expression was elevated in hepatocyte cells treated with TGF‐β1, and ROR‐γ protein levels were elevated in the fibrotic mouse livers and human livers with cirrhosis. Knockdown of ROR‐γ resulted in the attenuation of TGF‐β1‐induced EMT in hepatocytes. Strikingly, ROR‐γ bound to ROR‐specific DNA response elements (ROREs) in the promoter region of TGF‐β type I receptor (Tgfbr1) and Smad2, resulting in the downregulation of Tgfbr1 and Smad2 after silencing of ROR‐γ. Therapeutic delivery of shRNA against ROR‐γ attenuated hepatocyte EMT and ameliorated liver fibrosis in a mouse model of TAA‐induced liver fibrosis. Overall, our results suggest that ROR‐γ regulates TGF‐β‐induced EMT in hepatocytes during liver fibrosis. We suggest that ROR‐γ may become a potential therapeutic target in treating liver fibrosis. J. Cell. Biochem. 118: 2026–2036, 2017. © 2016 The Authors. Journal of Cellular Biochemistry Published by Wiley Periodicals Inc. 相似文献
15.
16.
17.
Peng Zhou Xinyu Zhang Mengqi Guo Rong Guo Lei Wang Zihao Zhang Zongwei Lin Mei Dong Hongyan Dai Xiaoping Ji Huixia Lu 《Journal of cellular and molecular medicine》2019,23(10):7088-7098
Vascular calcification (VC) is a pathological process underpinning major cardiovascular conditions and has attracted public attention due to its high morbidity and mortality. Chronic kidney disease (CKD) is a common disease related to VC. Ginsenoside Rb1 (Rb1) has been reported to protect the cardiovascular system against vascular diseases, yet its role in VC and the underlying mechanisms remain unclear. In this study, we established a CKD‐associated VC rat model and a β‐glycerophosphate (β‐GP)‐induced vascular smooth muscle cell (VSMC) calcification model to investigate the effects of Rb1 on VC. Our results demonstrated that Rb1 ameliorated calcium deposition and VSMC osteogenic transdifferentiation both in vivo and in vitro. Rb1 treatment inhibited the Wnt/β‐catenin pathway by activating peroxisome proliferator‐activated receptor‐γ (PPAR‐γ), and confocal microscopy was used to show that Rb1 inhibited β‐catenin nuclear translocation in VSMCs. Furthermore, SKL2001, an agonist of the Wnt/β‐catenin pathway, compromised the vascular protective effect of Rb1. GW9662, a PPAR‐γ antagonist, reversed Rb1's inhibitory effect on β‐catenin. These results indicate that Rb1 exerted anticalcific properties through PPAR‐γ/Wnt/β‐catenin axis, which provides new insights into the potential theraputics of VC. 相似文献
18.
19.