共查询到20条相似文献,搜索用时 15 毫秒
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Regulation of Laminin γ2 Expression by CDX2 in Colonic Epithelial Cells Is Impaired During Active Inflammation 下载免费PDF全文
Mehmet Coskun Christoffer Soendergaard Steffen Joergensen Katja Dahlgaard Lene Buhl Riis Ole Haagen Nielsen Albin Sandelin Jesper Thorvald Troelsen 《Journal of cellular biochemistry》2017,118(2):298-307
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Statins Modulate Cyclooxygenase‐2 and Microsomal Prostaglandin E Synthase‐1 in Human Hepatic Myofibroblasts 下载免费PDF全文
Charbel A. Mouawad May F. Mrad Ghewa A. El‐Achkar Ali Abdul‐Sater Georges M. Nemer Christophe Creminon Sophie Lotersztajn Aïda Habib 《Journal of cellular biochemistry》2016,117(5):1176-1186
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Anti‐Inflammatory and Anti‐Oxidant Effects of p‐Chloro‐phenyl‐selenoesterol on TNBS‐Induced Inflammatory Bowel Disease in Mice 下载免费PDF全文
Micheli Stéfani Zarzecki Vandreza Cardoso Bortolotto Márcia Rósula Poetini Stífani Machado Araujo Mariane Trindade de Paula Silvane Souza Roman Cristiano Spiazzi Franciele Weber Santos Cibin Oscar Endrigo Dorneles Rodrigues Cristiano Ricardo Jesse Marina Prigol 《Journal of cellular biochemistry》2017,118(4):709-717
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miR‐124 Negatively Regulates Osteogenic Differentiation and In vivo Bone Formation of Mesenchymal Stem Cells 下载免费PDF全文
Abdul S. Qadir Soyoun Um Heesu Lee Kyunghwa Baek Byoung Moo Seo Gene Lee Gwan‐Shik Kim Kyung Mi Woo Hyun‐Mo Ryoo Jeong‐Hwa Baek 《Journal of cellular biochemistry》2015,116(5):730-742
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Adam S. Raymond Brooke Elder Michael Ensslin Barry D. Shur 《Molecular reproduction and development》2010,77(6):550-563
SED1/MFG‐E8, herein referred to as SED1, is a bimotif adhesive protein with ascribed functions in a range of cell–cell interactions, including sperm‐egg binding. In the male reproductive tract, SED1 is secreted by the initial segment of the epididymis, where it coats sperm and subsequently facilitates binding to the egg zona pellucida. We have recently reported that SED1‐null epididymides show an unexpected incidence of spermatic granulomas, reflecting breakdown of the epithelium and a consequent autoimmune response against sperm antigens. However, spermatic granulomas are most often manifest in the distal segments of the epididymis, whereas the bulk of SED1 is expressed in the proximal epididymis. In some models, the presence of granulomas in the distal epididymis is associated with an underlying defect in the maintenance of luminal fluid homeostasis. Herein, we report that SED1‐null epididymal fluid is both hypo‐osmotic and alkaline, relative to wildtype epididymal fluid. Furthermore, the SED1‐null epididymal epithelium exhibits various hallmarks of disrupted fluid reabsorption and pH regulation, including altered morphology of clear cells, increased intracellular vesicles, and apical distribution of VATPase. Results indicate that the SED1‐null epididymal pathologies are not the secondary consequences of defective testes or efferent ducts or of improper epididymal differentiation, unlike that seen in other epididymal models. The expression and distribution of various ion exchangers, channels, and enzymes that mediate fluid transport and pH regulation are examined in wildtype and SED1‐null epididymides, and models to account for how SED1 functions in luminal fluid dynamics are discussed. Mol. Reprod. Dev. 77: 550–563, 2010. © 2010 Wiley‐Liss, Inc. 相似文献
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Anti‐Inflammatory Effect of Ascochlorin in LPS‐Stimulated RAW 264.7 Macrophage Cells Is Accompanied With the Down‐Regulation of iNOS,COX‐2 and Proinflammatory Cytokines Through NF‐κB,ERK1/2, and p38 Signaling Pathway 下载免费PDF全文
Sook‐Hyun Lee Choong‐Hwan Kwak Sung‐Kyun Lee Sun‐Hyung Ha Junyoung Park Tae‐Wook Chung Ki‐Tae Ha Suk‐Jong Suh Young‐Chae Chang Hyeun Wook Chang Young‐Choon Lee Bong‐Seok Kang Junji Magae Cheorl‐Ho Kim 《Journal of cellular biochemistry》2016,117(4):978-987