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Transcriptional profiling implicates novel interactions between abiotic stress and hormonal responses in Thellungiella, a close relative of Arabidopsis 总被引:8,自引:0,他引:8
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Wong CE Li Y Labbe A Guevara D Nuin P Whitty B Diaz C Golding GB Gray GR Weretilnyk EA Griffith M Moffatt BA 《Plant physiology》2006,140(4):1437-1450
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Shelley A. Phelan David R. Beier David C. Higgins Beverly Paigen 《Mammalian genome》2002,13(10):548-553
Previously, we demonstrated that Ath1 is a quantitative trait locus for aortic fatty streak formation, located on Chromosome
(chr) 1, with susceptibility in C57BL/6J mice and resistance in C3H/HeJ and BALB/cJ mice fed an atherogenic diet. In this
study, we find an atherosclerosis susceptibility locus in the same region of Chr 1 by constructing two congenic strains with
the resistance phenotype transferred from different resistant strains, PERA/EiJ or SPRETUS/EiJ. By backcrossing one congenic
strain to C57BL/6J and testing recombinant animals, we reduced the distance of the atherosclerosis susceptibility region to
2.3 cM between D1Mit14 and D1Mit10. Further testing of nine recombinant animals showed that eight of the nine were consistent
with a further narrowing between D1Mit159 and D1Mit398 a distance of 0.66 cM. This region encompasses a number of potential
candidate genes including the thiol-specific antioxidant gene Aop2, also known as peroxiredoxin 5 (Prdx5). AOP2 is capable
of reducing hydroperoxides and lipid peroxides in the cell. To investigate Aop2 as a potential candidate, we mapped Aop2 in
our backcross and localized it to the atherosclerosis susceptibility interval. We determined that Aop2 is highly expressed
in atherosclerosis-related tissues including liver and heart. We also found an inverse correlation between Aop2 mRNA in liver
and atherosclerosis phenotype for strains C57BL/6 and the resistant congenic derived from SPRETUS/EiJ. Since LDL oxidation
has been implicated in the pathogenesis of this disease, and AOP2 possesses antioxidant activity, we suggest the role of Aop2
in atherosclerosis susceptibility needs to be further explored. 相似文献