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The phytophagous insects of the Tephritidae family commonly referred to as “true fruit flies” offer different case histories
of successful invasions. Mankind has played an important role in altering the distributions of some of the more polyphagous
and oligophagous species. However, the question arises why only a few species have become major invaders. The understanding
of traits underlying adaptation in different environments is a major topic in invasion biology. Being generalists or specialists,
along the K–r gradient of the growth curve, make a difference in term of food resources exploitation and interspecies competition and displacement.
The species of the genus Ceratitis are good examples of r-strategists. The genetic and biological data of the most notorious Ceratitis species, the Mediterranean fruit fly Ceratitis capitata (medfly), are reviewed to investigate the traits and behaviours that make the medfly an important invader. It can be learnt
from medfly, that invasions in a modern global trade network tend to be due to multiple introductions. This fact allows a
maintenance or enhancement of genetic variability in the adventive populations, which in turn increases their potential invasiveness.
Our current knowledge of the medfly genome opens the way for future studies on functional genomics. 相似文献
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Bernadette Murgue 《Microbes and infection / Institut Pasteur》2010,12(2):113-118
Severe dengue has been recognised for more than 200 years, but attempts to define, categorize and explain the condition have hotly contested for more than four decades. Resolution of this controversy may provide new insights for the management of patients. 相似文献
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DSB repair: the yeast paradigm 总被引:1,自引:0,他引:1
Genome stability is of primary importance for the survival and proper functioning of all organisms. Double-strand breaks (DSBs) arise spontaneously during growth, or can be created by external insults. In response to even a single DSB, organisms must trigger a series of events to promote repair of the DNA damage in order to survive and restore chromosomal integrity. In doing so, cells must regulate a fine balance between potentially competing DSB repair pathways. These are generally classified as either homologous recombination (HR) or non-homologous end joining (NHEJ). The yeast Saccharomyces cerevisiae is an ideal model organism for studying these repair processes. Indeed, much of what we know today on the mechanisms of repair in eukaryotes come from studies carried out in budding yeast. Many of the proteins involved in the various repair pathways have been isolated and the details of their mode of action are currently being unraveled at the molecular level. In this review, we focus on exciting new work eminating from yeast research that provides fresh insights into the DSB repair process. This recent work supplements and complements the wealth of classical genetic research that has been performed in yeast systems over the years. Given the conservation of the repair mechanisms and genes throughout evolution, these studies have profound implications for other eukaryotic organisms. 相似文献
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Aim Three paradigm patterns of post‐glacial dispersal are known for terrestrial species in Europe. However, the possibility of a fourth arises with the Italian and the Balkan lineages expanding to central Europe and the Iberian one being trapped by the Pyrenees. We test this hypothesis by analysing the molecular biogeography of the Marbled White butterfly. Location Twelve populations distributed over a major part of the European range of Melanargia galathea and M. lachesis. Methods We studied 18 allozyme loci of 403 individuals from 12 populations. Butterflies were sampled in the field, frozen in liquid nitrogen and stored under these conditions until analysis. We used cellulose acetate plates for allozyme electrophoresis. Results We detected three major genetic lineages within the M. galathea/lachesis complex. The M. lachesis sample from the southern Pyrenees was strongly genetically differentiated from M. galathea (FCT: 0.312). Melanargia galathea splits into two major genetic lineages (FCT: 0.115), which both were found in post‐glacially invaded regions. The further differentiation within these lineages was comparably low (FSC: 0.028). The genetic diversity within populations was high compared with other butterfly species. Main conclusions Our findings support the existence of a fourth pattern with only the Iberian lineage not contributing considerably to the post‐glacial colonization of central Europe. Preliminary studies in other butterfly species of dry grasslands support the importance of this pattern possibly representing a fourth paradigm. The high genetic diversity within populations might be one reason for the recently observed expansions at the northern distribution limits. 相似文献
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Most of our knowledge about the mechanisms of segmentation in arthropods comes from work on Drosophila melanogaster. In recent years it has become clear that this mechanism is far from universal, and different arthropod groups have distinct modes of segmentation that operate through divergent genetic mechanisms. We review recent data from a range of arthropods, identifying which features of the D. melanogaster segmentation cascade are present in the different groups, and discuss the evolutionary implications of their conserved and divergent aspects. A model is emerging, although slowly, for the way that arthropod segmentation mechanisms have evolved. 相似文献
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Proteome--the protein complement of a genome--has become the protein renaissance and a key research tool in the post-genomic era. The basic technology involves the routine usage of gel electrophoresis and spectrometry procedures for deciphering the primary protein sequence/structure as well as knowing certain unique post-translational modifications that a particular protein has undergone to perform a specific function in the cell. However, the recent advancements in protein analysis have ushered this science to provide deeper, bigger and more valuable perspectives regarding performance of subtle protein-protein interactions. Applications of this branch of molecular biology are as vast as the subject is and include clinical diagnostics, pharmaceutical and biotechnological industries. The 21st century hails the use of products, procedures and advancements of this science as finer touches required for the grooming of fast-paced technology. 相似文献
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Multimeric glycotherapeutics: New paradigm 总被引:3,自引:0,他引:3
The general principle of anti-adhesion therapy is the inhibition of microorganism adhesion to the host cell with the help of a soluble receptor analog. Despite an evident attractiveness of the concept and its long existence, the therapeutics of the post-antibiotic era have not yet appeared. This can be explained by the contradictoriness of requirements for anti-adhesion drugs: to be efficient a drug must be multivalent, i.e. large molecule, but to obtain FDA approval it should be a small molecule. A way to overcome this contradiction is self-assembly of glycopeptides. The carbohydrate part of glycopeptide is responsible for binding with the lectin of microorganisms, whereas a simple peptide part is responsible for an association to the so-called tectomers. Depending on the structure, tectomers are formed either spontaneously or upon promotion of a microorganism. In particular, sialopeptide, which is capable of converting to a tectomer only in the presence of the influenza virus, has been obtained. Thus, the new strategy of anti-adhesion therapy can be formulated as follows: (1) identification of oligosaccharide-receptor for a particular virus (bacteria); (2) optimization of the peptide part; (3) conventional trials. The expected advantages of this strategy are the following: (i) no polymer; (ii) a virion completely covered with a tectomer, i.e. blocking is both complete and irreversible; (iii) rapid and rational lead identification and optimization; (iv) minimum side effects; (v) potential for microorganism resistance to natural receptor is lower than in the case of mimetics. Published in 2004. 相似文献
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Oudejans CB van Dijk M Oosterkamp M Lachmeijer A Blankenstein MA 《Human genetics》2007,120(5):607-612
Segregation of preeclampsia into early-onset, placental and late-onset, maternal subtypes along with the acknowledgement of
the contribution of epigenetics in placentally expressed genes proved to be a key first step in the identification of essential
gene variants associated with preeclampsia. Application of this insight to other populations and related pregnancy-induced
syndromes, such as HELLP, and acknowledgment of the features shared between chromosomal loci associated with preeclampsia
in different populations provide the rationale for new strategies for the identification of susceptibility genes and for new
and more effective diagnostic strategies.
Electronic supplementary material Supplementary material is available in the online version of this article at and is accessible for authorized users. 相似文献
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Comparative analysis of the complete sequences of seven bacterial and three archaeal genomes leads to the first generalizations of emerging genome-based microbiology. Protein sequences are, generally, highly conserved, with ∼70% of the gene products in bacteria and archaea containing ancient conserved regions. In contrast, there is little conservation of genome organization, except for a few essential operons. The most striking conclusions derived by comparison of multiple genomes from phylogenetically distant species are that the number of universally conserved gene families is very small and that multiple events of horizontal gene transfer and genome fusion are major forces in evolution. 相似文献
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Biomolecular motors: the F1-ATPase paradigm 总被引:2,自引:0,他引:2
The realization that many essential functions of living cells are performed by nanoscale motors consisting of protein complexes has given rise to an intense effort to understand their mechanisms. Considerable progress has been made in the past two years by a combination of biophysical techniques and theoretical analysis. Single-molecule studies have played a spectacular role for a variety of motors including kinesin, myosin, and polymerases. The understanding of F(1)-ATPase, the smallest biomolecular rotary motor, has made particular progress by the interplay of experimental and theoretical studies; the latter have provided information not available from experiment. 相似文献
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In vitro expansion of GGC:GCC repeats: identification of the preferred strand of expansion. 总被引:2,自引:1,他引:1 下载免费PDF全文
J Ji N J Clegg K R Peterson A L Jackson C D Laird L A Loeb 《Nucleic acids research》1996,24(14):2835-2840
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Manipulation of parasitoid size using the temperature-size rule: fitness consequences 总被引:1,自引:0,他引:1
The phenotypic effects of rearing temperature on several fitness components of the koinobiont parasitoid, Aphidius colemani, were examined. Temperatures experienced during development induced a plastic linear response in the dry and fat masses of
the immature stage and a non-linear response in the growth rate as well as in the size of adults. We investigated if the phenotypic
morphometrical plasticity exhibited by parasitoids reared at different temperatures can induce variations in fitness-related
traits in females. We did not find any difference in immature (pupal) mortality in accordance to rearing temperature. However,
when examining adult longevity, we found an inverse linear relation with developmental temperature, confirming the usual rule
that larger and fatter wasps live longer than smaller ones. The pattern of female fecundity was non-linear; wasps that developed
at high and low temperatures were less productive. We suggest that when development is short, the accumulated reserves are
not adequate to support both fecundity and survival. By manipulating adult size through changes in the rearing temperature,
we showed that the usual shape of the size/fitness function is not always linear as expected. Developmental temperature induced
a plasticity in energy reserves which affected the functional constraints between survival and reproduction. 相似文献