Transmembrane dimers of type 1 receptors sample alternate configurations: MD simulations using coarse grain Martini 3 versus AlphaFold2 Multimer

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The C2 and PH domains of CAPS constitute an effective PI(4,5)P2-binding unit essential for Ca2+-regulated exocytosis

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Structural and Functional Impact of SRP54 Mutations Causing Severe Congenital Neutropenia

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Predictable cholesterol binding sites in GPCRs lack consensus motifs

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Structure of the ancient TRPY1 channel from Saccharomyces cerevisiae reveals mechanisms of modulation by lipids and calcium

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Filopodium-derived vesicles produced by MIM enhance the migration of recipient cells

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Polycomb Group Proteins Regulate Chromatin Architecture in Mouse Oocytes and Early Embryos

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The ZMYND8-regulated mevalonate pathway endows YAP-high intestinal cancer with metabolic vulnerability

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Allosteric Activation of PI3Kα Results in Dynamic Access to Catalytically Competent Conformations

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Structure Determination from Lipidic Cubic Phase Embedded Microcrystals by MicroED

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Structure and thermodynamics of transient protein-protein complexes by chemometric decomposition of SAXS datasets

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Autophosphorylation transforms DNA-PK from protecting to processing DNA ends

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The structure of an Hsp90-immunophilin complex reveals cochaperone recognition of the client maturation state

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The Mettl3 epitranscriptomic writer amplifies p53 stress responses

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Su(var)2-10 and the SUMO Pathway Link piRNA-Guided Target Recognition to Chromatin Silencing

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Glucose starvation induces autophagy via ULK1-mediated activation of PIKfyve in an AMPK-dependent manner

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HMCES Functions in the Alternative End-Joining Pathway of the DNA DSB Repair during Class Switch Recombination in B Cells

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Directed Differentiation of Notochord-like and Nucleus Pulposus-like Cells Using Human Pluripotent Stem Cells

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TRIP12 ubiquitination of glucocerebrosidase contributes to neurodegeneration in Parkinson’s disease

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Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers

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