Vps37a regulates hepatic glucose production by controlling glucagon receptor localization to endosomes

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PPP6C negatively regulates oncogenic ERK signaling through dephosphorylation of MEK

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Sensory circuitry controls cytosolic calcium-mediated phytochrome B phototransduction

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Glial-secreted Netrins regulate Robo1/Rac1-Cdc42 signaling threshold levels during Drosophila asymmetric neural stem/progenitor cell division

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Endocardium-to-coronary artery differentiation during heart development and regeneration involves sequential roles of Bmp2 and Cxcl12/Cxcr4

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Excessive R-loops trigger an inflammatory cascade leading to increased HSPC production

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A gap-junction-mediated,calcium-signaling network controls blood progenitor fate decisions in hematopoiesis

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Synergistic interaction of gut microbiota enhances the growth of nematode through neuroendocrine signaling

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Receptor-associated independent cAMP nanodomains mediate spatiotemporal specificity of GPCR signaling

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Proteasome stress in skeletal muscle mounts a long-range protective response that delays retinal and brain aging

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C. elegans Males Integrate Food Signals and Biological Sex to Modulate State-Dependent Chemosensation and Behavioral Prioritization

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Injury primes mutation-bearing astrocytes for dedifferentiation in later life

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Symmetric Arginine Dimethylation Is Selectively Required for mRNA Splicing and the Initiation of Type I and Type III Interferon Signaling

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Nod factor receptor complex phosphorylates GmGEF2 to stimulate ROP signaling during nodulation

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A Bartonella Effector Acts as Signaling Hub for Intrinsic STAT3 Activation to Trigger Anti-inflammatory Responses

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BMP-gated cell-cycle progression drives anoikis during mesenchymal collective migration

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KIF3B promotes a PI3K signaling gradient causing changes in a Shh protein gradient and suppressing polydactyly in mice

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Transient Primary Cilia Mediate Robust Hedgehog Pathway-Dependent Cell Cycle Control

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Structure-guided optimization of light-activated chimeric G-protein-coupled receptors

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Specialized endothelial tip cells guide neuroretina vascularization and blood-retina-barrier formation

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