共查询到20条相似文献,搜索用时 15 毫秒
1.
2.
3.
4.
5.
6.
7.
8.
9.
10.
11.
12.
《BMJ (Clinical research ed.)》1961,2(5244):119-120,121
13.
14.
15.
16.
《BMJ (Clinical research ed.)》1958,2(5103):1047-1048
17.
18.
Jeschke P Benet-Buchholz J Harder A Etzel W Schindler M Thielking G 《Bioorganic & medicinal chemistry letters》2003,13(19):3285-3288
The (S,S,S,R,S,R)-configurated cyclohexadepsipeptides (CHDPs) represent novel enniatin derivatives with strong in vivo activity against the parasitic nematode Haemonchus contortus Rudolphi in sheep. 2D NMR spectroscopic analysis revealed for the major conformation the asymmetric conformer, containing a cis-amide bond between C(alpha) protons of neighbouring 2-hydroxy-(S)-carboxylic acid and N-methyl-(S)-amino acid. The absolute configuration of the novel CHDPs was determined by X-ray crystallography. A correlation between the major conformer and its anthelmintic activity was found. Here, we report on a simple total synthetic pathway for this particular type of CHDPs. 相似文献
19.
20.