共查询到7条相似文献,搜索用时 15 毫秒
1.
New Cytotoxic Saponins from Lysimachia davurica Ledeb. 总被引:2,自引:0,他引:2
Jing-Kui Tian Zhong-Mei Zou Li-Zhen Xu Shi-Lin Yang 《植物学报(英文版)》2006,48(2):232-235
To investigate the saponins from whole plants of Lysimachia davurica Ledeb., two new saponins named davuricoside I (compound 1) and E (compound 2) were isolated. Their chemical structures were elucidated as 3β, 16α, 28, 29-tetrihydroxy-olean-12-en-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 1) and 3β, 16α, 29-trihydroxy-13, 28-epoxy-oleanane-3-O-β-D-glucopyranosyl-(1→2)-β-D-glucuronopyranoside (compound 2) on the basis of their one- and two-dimensional nuclear magnetic resonance and mass spectrometry data, and chemical methods. Compound 1 showed significant cytotoxic activity against human A2780 cells. 相似文献
2.
Tribulus terrestris is a valuable herb known for its application in the folk medicine in many parts of the world. Furostanol and spirostanol
saponins of tigogenin, neotigogenin, gitogenin, neogitogenin, hecogenin, neohecogenin, diosgenin, chlorogenin, ruscogenin
and sarsasapogenin type are frequently found in this plant. Four sulphated saponins of tigogenin and diosgenin type are also
isolated. Extracts and steroidal saponins have been found to possess various pharmacological activities. Preparations based
on the saponin fraction of T. terrestris are used for treatment of infertility and libido disorders in men and women, as well as for treatment of cardiac diseases.
Food supplements containing T. terrestris extracts are on sale in USA and Europe with claim of a general stimulating action.
In this review the steroidal saponins found in T. terrestris are presented, covering the literature up to 2004. The data reveal clear difference in the saponin composition of samples
from this plant species collected from different geographical regions. A comprehensive account on the biological activity
of extracts and individual saponins is also included. 相似文献
3.
Gui-Yan Liu Shuang-Cheng Ma Jian Zheng Ji Zhang Rui-Chao Lin 《植物学报(英文版)》2007,49(2):196-201
Two new triterpenoid saponins, hederagenin 3-O-α-L-arabinopyranosyl-(1→〉2)-α-L-arabinopyranoside named akeboside La (compound 1), oleanolic acid 3-O-α-L-arabinopyranosyl-(1→〉2)-β-D-glucopyranoside named akeboside Lb (compound 2), along with five known saponins, oleanolic acid 3-O-α-L-rhamnopyranosyl-(1→〉2)-α-L- arabinopyranoside (compound 3), hederagenin 3-O-α-L-rhamnopyranosyl-(1→〉2)-α-L-arabinopyranoside (compound 4), oleanolic acid 3-O-β-D-xylopyranosyl-(1→〉3)-α-L-rhamnopyranosyl-(1→〉2)-α-L-arabinopyranoside (compound 5), 3-O-α-L-rhamnopyranosyl-(1→〉2)-α-L-arabinopyranosyl oleanolic acid 28-O-α-L-rhamnopyranosyl-(1→〉4)-α-D- glucopyranosyl-(1→〉6)-β-D-glucopyranoside (compound 6), 3-O-α-L-rhamnopyranosyl-(1→〉2)-α-L-arabinopyranosyl hederagenin 28-α-L-rhamnopyranosyl-(1→〉4)-β-D-glucopyranosyl-(1→〉6)-β-D-glucopyranoside (compound 7) were isolated from the n-butanol part of the 80% ethanol extracts of the dried stems of Akebia quinata (Thunb.) Decne. Compound 5 was isolated from plants of genus Akebia for the first time. The structures were elucidated on the basis of physicochemical properties and spectral data. 相似文献
4.
Tun-Hai Xu Ya-Juan Xu Dong Han Hong-Feng Zhao Sheng-Xu Xie Dong-Ming Xu 《植物学报(英文版)》2007,49(2):202-206
To investigate saponins from the roots of Pulsatilla cernua (Thunb.) Bercht. et Opiz., two new compounds together with five known trlterpenold saponins were isolated. The structures of the two new trlterpenoid saponins, named cernuasides A and B, were elucidated as 3-O-[β-D-xylopyranosyl(1-)2)]-[α-L-rhamnopyranosyl(1-)4)]-α-L- arablnopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester (compound 1) and 3-O-[α-L-arabinopyranosyl(1→)3)]- [α-L-rhamnopyranosyl (1→)2)]-α-L-arabinopyranosyl hederagenin 28-O-β-D-glucopyranosyl ester (compound 2) by 1D, 2D-NMR techniques, ESIMS analysis, as well as chemical methods. 相似文献
5.
Saponins are secondary plant compounds. They have a triterpenoid or steroidal backbone. Sugars are attached to one or more points of this structure, forming chains that can be branched. This appearance leads to amphiphilic properties giving saponins the ability to interact with both lipophilic and hydrophilic structures. The surfactant behavior lets them lower the surface tension in aqueous solutions and form micelles when reaching the critical micelle concentration (cmc). It also lets them interact with biologic membrane layers that usually consist of phospholipids and cholesterol. This action may perturb the membrane and its function leading to membrane perforation or complete lysis. Thus saponins are also known for their cytotoxicity and membranolytic, respectively hemolytic features. In our studies we wanted to answer the question if there is a correlation between the unspecific detergent behavior when lowering the surface tension and the ability to perforate cell membranes and to act cytotoxic. Do saponins showing a considerable reduction in the surface tension also reveal an evident cytotoxicity or/and a marked cell membrane perforation?We tested a variety of saponins with distinct structures. The reduction in the surface tension and the cmc were analyzed on a tensiometer using the Wilhelmy plate method. The general cytotoxicity was determined in a cell model by DNA quantification. The cell membrane toxicity or membrane perforation was explored in a cell model by quantification of the leakage of the intracellular enzyme lactate dehydrogenase (LDH).The experiments revealed a correlation between the membrane toxicity and the reduction in surface tension. 相似文献
6.
Sobolewska Danuta Galanty Agnieszka Grabowska Karolina Makowska-Wąs Justyna Wróbel-Biedrawa Dagmara Podolak Irma 《Phytochemistry Reviews》2020,19(1):139-189
Phytochemistry Reviews - Steroidal saponins are a group of glycosides widely distributed among monocotyledonous families. They exert a wide spectrum of biological effects including cytotoxic and... 相似文献
7.
Podolak Irma Grabowska Karolina Sobolewska Danuta Wróbel-Biedrawa Dagmara Makowska-Wąs Justyna Galanty Agnieszka 《Phytochemistry Reviews》2023,22(1):113-167
Phytochemistry Reviews - Saponins make up an important group of natural glycosidic compounds which are distinguished by triterpene or steroidal aglycone. Although widely distributed in terrestrial... 相似文献