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1.
P. Viau P. FrankenB. Padovani P.-M. Koulibaly J. BenolielM. Razzouk J. Darcourt 《Médecine Nucléaire》2011,35(3):117-125
Purpose
V/P-SPECT lung scan can be combined with computerized tomography (CT) from hybrid camera. We investigated if CT data could be use only with perfusion scans for the diagnosis of acute pulmonary embolism (PE).Patients and methods
In a retrospective study, 75 consecutives patients, referred for suspicion of PE, underwent SPECT ventilation and perfusion scans coupled with a CT on Symbia T2. The perfusion images (P-SPECT) were classified as normal or abnormal with systematized (segmental and sub-segmental) or not systematized perfusion abnormalities. The ventilation images (V-SPECT) were considered as normal or abnormal in light of perfusion defects. The same was done for CT images. Correlations between V-SPECT and CT were studied.Results
Hence, 28 patients had a normal P-SPECT and did not have PE. Patients (47) had an abnormal P-SPECT (among them, 16 turned out to have PE and 31 did not). There were 192 perfusion abnormalities of which 81 were segmental and 81 sub-segmental. Corresponding to these abnormalities, V-SPECT and CT were concordant in 83 % of the cases. When not-concordant, V-SPECT abnormalities with normal CT were found in 14 % of the cases and CT abnormalities with normal V-SPECT were found in 3 % of the cases. According to the EANM guidelines for PE diagnosis, sensitivity was 88 % and specificity 93 % with V/P-SPECT and 100 % and 83 % respectively with CT/P-SPECT (p = NS).Conclusion
V/P-SPECT remains slightly more specific for the diagnosis of PE. However, this study demonstrates that CT/P-SPECT obtained with hybrid camera could be used for PE diagnosis with performances similar to V/P-SPECT. If these results would be confirmed on larger populations, this could lead to a significant reduction of scanning time which would improve patient comfort and reduce the camera load. 相似文献2.
Anne S Rasmussen Henrik Lauridsen Christoffer Laustsen Bjarke G Jensen Steen F Pedersen Lars Uhrenholt Lene WT Boel Niels Uldbjerg Tobias Wang Michael Pedersen 《BMC physiology》2010,10(1):3
Background
In biomedical sciences, ex vivo angiography is a practical mean to elucidate vascular structures three-dimensionally with simultaneous estimation of intravascular volume. The objectives of this study were to develop a magnetic resonance (MR) method for ex vivo angiography and to compare the findings with computed tomography (CT). To demonstrate the usefulness of this method, examples are provided from four different tissues and species: the human placenta, a rice field eel, a porcine heart and a turtle. 相似文献3.
Jeanne A. M. C. Dirks Petra F. G. Wolffs Nicole H. T. M. Dukers-Muijrers Antoinette A. T. P. Brink Arjen G. C. L. Speksnijder Christian J. P. A. Hoebe 《PloS one》2015,10(3)
Objectives
If the Chlamydia trachomatis (CT) bacterial load is higher in high-risk populations than in the general population, this negatively affects the efficacy of CT screening incentives. In the largest retrospective study to date, we investigated the CT load in specimens collected from 2 cohorts: (1) attendants of a sexually transmitted infection (STI)-clinic and (2) participants of the Dutch population-based screening (PBS).Methods
CT load was determined using quantitative PCR in CT-positive male urine and female cervicovaginal swabs. CT loads were converted into tertiles. Using multinominal logistic regression, independent association of cohort, symptoms, risk behaviour and human cell count on load were assessed.Results
CT loads were determined in 889 CT-positives from PBS (n = 529; 71.8% female) and STI-clinics (n = 360; 61.7% female). In men, STI-clinic-cohort, human cell count and urethral discharge were positively associated with CT load. In women, PBS-cohort and cell count were positively associated with CT load. Both cohorts had the same range in CT load.Conclusions
The general population has a similar range of bacterial CT load as a high-risk population, but a different distribution for cohort and gender, highlighting the relevance of population-based CT-screening. When CT loads are similar, possibly the chances of transmission and sequelae are too. 相似文献4.
Irmler IM Opfermann T Gebhardt P Gajda M Bräuer R Saluz HP Kamradt T 《Arthritis research & therapy》2010,12(6):R203
Introduction
The purpose of this work was to establish and validate combined small animal positron emission tomography - computed tomography (PET/CT) as a new in vivo imaging method for visualisation and quantification of joint inflammation. 相似文献5.
Raja S Payyavula Benjamin A Babst Matthew P Nelsen Scott A Harding Chung-Jui Tsai 《BMC plant biology》2009,9(1):151
Background
Phenylpropanoid-derived phenolic glycosides (PGs) and condensed tannins (CTs) comprise large, multi-purpose non-structural carbon sinks in Populus. A negative correlation between PG and CT concentrations has been observed in several studies. However, the molecular mechanism underlying the relationship is not known. 相似文献6.
Carolina C Otoni Sheila C Rahal Luiz C Vulcano Sérgio M Ribeiro Khadije Hette Tatiana Giordano Danuta P Doiche Renée L Amorim 《Acta veterinaria Scandinavica》2010,52(1):20
Background
Accurate early diagnosis of lung metastases is important for establishing therapeutic measures. Therefore, the present study aimed to compare survey thoracic radiographs and computerized tomography (CT) scans to specifically identify lung metastases in female dogs with mammary tumors. 相似文献7.
Rishein Gupta Pragya Srivastava Harsh Vardhan Sudha Salhan Aruna Mittal 《Reproductive biology and endocrinology : RB&E》2009,7(1):38-18
Background
With an increase in the number of putative inclusion membrane proteins (incs) in chlamydial genomes, there is a need for understanding their contribution in host-pathogen interactions. Thus in this study we determined the host mucosal and peripheral immune responses to incs (IncB and IncC) of Chlamydia trachomatis (CT). 相似文献8.
Marc Kelliny Philippe Maeder Stefano Binaghi Marc Levivier Luca Regli Reto Meuli 《BMC neurology》2011,11(1):8
Background
To identify patients with spontaneous subarachnoid hemorrhage for whom CT angiography alone can exclude ruptured aneurysms. 相似文献9.
Rishein Gupta Harsh Vardhan Pragya Srivastava Sudha Salhan Aruna Mittal 《Reproductive biology and endocrinology : RB&E》2009,7(1):84-13
Background
Chlamydial Inclusion membrane proteins (Incs), are involved in biochemical interactions with host cells and infecting Chlamydiae. We have previously reported the role of two Chlamydia trachomatis (CT) Incs, namely IncB and IncC in generating host immunity in CT infected women. Emerging data shows involvement of Inc stimulated CD4 positive T cells in aiding host immunity in infected fertile and infertile women through the secretion of interferon gamma. However the lack of data on the intra-cytokine interplay to these Incs in infected cell milieu prompted us to investigate further. 相似文献10.
Background
Creatine (Cr) is synthesized by a two-step mechanism involving arginine:glycine amidinotransferase (AGAT) and guanidinoacetate methyltransferase (GAMT), and is taken up by cells through a specific Cr transporter, CT1. Recently, genetic defects of this pathway have been described, that lead to Cr deficiency, neurological symptoms in early infancy and severe neurodevelopmental delay. To investigate the involvement of Cr synthesis and uptake pathways during embryonic development, we determined the spatiotemporal expression of AGAT, GAMT and CT1 during the rat embryogenesis, at the mRNA and protein level. 相似文献11.
Karen M Moody Lawrence B Schonberger Ryan A Maddox Wen-Quan Zou Laura Cracco Ignazio Cali 《BMC neurology》2011,11(1):136
Background
Sporadic fatal insomnia (sFI) and fatal familial insomnia (FFI) are rare human prion diseases. 相似文献12.
Ralph Brandenberger Irina Khrebtukova R Scott Thies Takumi Miura Cai Jingli Raj Puri Tom Vasicek Jane Lebkowski Mahendra Rao 《BMC developmental biology》2004,4(1):10
Background
Pooled human embryonic stem cells (hESC) cell lines were profiled to obtain a comprehensive list of genes common to undifferentiated human embryonic stem cells. 相似文献13.
M Gehrmann S Stangl A Kirschner GA Foulds W Sievert BT Doss A Walch AG Pockley G Multhoff 《PloS one》2012,7(7):e41341
Background
We have previously reported that human recombinant granzyme B (grB) mediates apoptosis in membrane heat shock protein 70 (Hsp70)-positive tumor cells in a perforin-independent manner.Methodology/Principal Findings
Optical imaging of uptake kinetics revealed co-localization of grB with recycling endosomes (Rab9/11) as early as 5 min after internalization, with late endosomes (Rab7) after 30 min, and the lysosomal compartment (LAMP1/2) after 60 to 120 min. Active caspase-3-mediated apoptosis was induced in mouse CT26 monolayer cells and 3D tumor spheroids, but not in normal mouse endothelial cells. Granzyme B selectively reduced the proportion of membrane Hsp70-positive cells in CT26 tumor spheroids. Consecutive i.v. injections of recombinant human grB into mice bearing membrane Hsp70-positive CT26 tumors resulted in significant tumor suppression, and a detailed inspection of normal mouse organs revealed that the administration of anti-tumoral concentrations of grB elicited no clinicopathological changes.Conclusions/Significance
These findings support the future clinical evaluation of human grB as a potential adjuvant therapeutic agent, especially for treating immunosuppressed patients that bear membrane Hsp70-positive tumors. 相似文献14.
Mohan G Perilli E Kuliwaba JS Humphries JM Parkinson IH Fazzalari NL 《Arthritis research & therapy》2011,13(6):R210
Introduction
Osteoarthritis (OA) is a complex, multifactorial joint disease affecting both the cartilage and the subchondral bone. Animal models of OA aid in the understanding of the pathogenesis of OA and testing suitable drugs for OA treatment. In this study we characterized the temporal changes in the tibial subchondral bone architecture in a rat model of low-dose monosodium iodoacetate (MIA)-induced OA using in vivo micro-computed tomography (CT). 相似文献15.
Aim
To investigate the rate of persistence or/and recurrence of follicular cell-derived thyroid cancer with elevated serum antithyroglobulin antibody (TgAb) one year after ablative therapy. We also evaluated the predictive factors of persistence or/and recurrence and the clinical impact of PET/CT with FDG.Methods
This retrospective study involved 154 TgAb+ patients. PET/CT was performed in 22 patients with a pejorative anatomo-clinical type. The results of the PET/CT were compared with histology and clinical follow-up.Results
In 23 cases, thyroglobulin (Tg) was positive (14% of TgAb+ Tg+) while in other 131 cases, stimulated Tg was negative (86% of TgAb+ Tg−). Twenty-nine patients (18%) were finally diagnosed with persistent or recurrent disease during follow-up. Independent predictive factors were: age higher than 60 years, Tg+, increase of TgAb concentration in the first year following surgery, and T3/T4/N1 status. PET/CT showed sensitivity of 66% and specificity of 90%. Positivity of PET/CT was significantly associated with a poor prognosis.Discussion and conclusion
There is no significant association between persistence of TgAb and persistent/recurrent disease when stimulated Tg is negative. An increase of TgAb concentration in the first year of follow-up is an important prognostic indicator. PET/CT with FDG seems to be very useful in the therapeutic management of differentiated thyroid cancer, especially for the patients with pejorative anatomo-clinical types. 相似文献16.
Background
Only one spliceosomal-type intron has previously been identified in the unicellular eukaryotic parasite, Giardia lamblia (a diplomonad). This intron is only 35 nucleotides in length and is unusual in possessing a non-canonical 5' intron boundary sequence, CT, instead of GT. 相似文献17.
X. Poullias M. GuernouS. Hapdey A. HitzelA. Salles P. VeraA. Edet-Sanson 《Médecine Nucléaire》2011,35(3):96-104
Purpose
To assess dual-tracer imaging of hybrid SPECT/CT (S/CT) compared to planar scintigraphy (S/PL) and ultrasounds (US), in preoperative localization hyperparathyroidism.Methods
Dual tracer S/CT, S/PL and US for preoperative localization were performed in 99 patients with hyperparathyroidism. Patients with single-gland and multiple gland disease (MGD) were evaluated. For S/PL and S/CT, 15 MBq of 123I were given and 2 hours later, 555 MBq/kg of 99mTc-MIBI was injected. Images were acquired simultaneously using appropriate windows in S/PL and S/CT, then compared to US. Thus, the predicted positions were compared to the intraoperative findings and abnormal parathyroid glands were measured.Results
Seventy-five patients underwent invasive surgery, which served as standard. Sixty-seven adenomas and 17 MGD were found on 70 patients. Sensitivity for US, S/PL and S/CT was respectively 69, 82 and 83%; and specificity was 96, 91 and 93% with an overall kappa-coefficient of 0.64, 0.73 and 0.76. US, S/PL and S/CT were correlated with the size of abnormal glands even if US remains the most accurate measuring technique. S/CT was able to predict the true position of the abnormal gland in 80% of cases.Conclusion
Dual-isotope planar imaging and S/CT were statistically significantly superior to US imaging in sensitivity. The addition of CT to SPECT further improves parathyroid adenoma localization and predicts the size, which can help for mini-invasive surgery. 相似文献18.
Autocrine regulation of human sperm motility by tachykinins 总被引:1,自引:0,他引:1
Francisco M Pinto Cristina G Ravina Nerea Subiran Antonio Cejudo-Román Manuel Fernández-Sánchez Jon Irazusta Nicolas Garrido Luz Candenas 《Reproductive biology and endocrinology : RB&E》2010,8(1):104
Background
We examined the presence and function of tachykinins and the tachykinin-degrading enzymes neprilysin (NEP) and neprilysin-2 (NEP2) in human spermatozoa. 相似文献19.
Michael Alper Randal Meyer Chris Dekkers Diego Ezcurra Joan Schertz Eduardo Kelly 《Reproductive biology and endocrinology : RB&E》2008,6(1):31
Background
The current study was designed to determine if follitropin alfa (recombinant human follicle-stimulating hormone; r-hFSH) and lutropin alfa (recombinant human luteinizing hormone; r-hLH) biopotencies were unchanged by reconstituting in sterile water for injection and mixing prior to injection. 相似文献20.
Jian Guo Andrew V Schally Marta Zarandi Jozsef Varga Peter CK Leung 《Reproductive biology and endocrinology : RB&E》2010,8(1):54