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A Sequence of the CIS Gene Promoter Interacts Preferentially with Two Associated STAT5A Dimers: a Distinct Biochemical Difference between STAT5A and STAT5B 总被引:5,自引:0,他引:5
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Frdrique Verdier Raquel Rabionet Fabrice Gouilleux Christian Beisenherz-Huss Paule Varlet Odile Muller Patrick Mayeux Catherine Lacombe Sylvie Gisselbrecht Stany Chretien 《Molecular and cellular biology》1998,18(10):5852-5860
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Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification 总被引:1,自引:0,他引:1
Nelson EA Walker SR Alvarez JV Frank DA 《The Journal of biological chemistry》2004,279(52):54724-54730
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Cytokine receptor common beta subunit-mediated STAT5 activation confers NF-kappa B activation in murine proB cell line Ba/F3 cells. 总被引:4,自引:0,他引:4
Tetsuya Nakamura Rika Ouchida Tsunenori Kodama Toshiyuki Kawashima Yuichi Makino Noritada Yoshikawa Sumiko Watanabe Chikao Morimoto Toshio Kitamura Hirotoshi Tanaka 《The Journal of biological chemistry》2002,277(8):6254-6265
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Litherland SA Grebe KM Belkin NS Paek E Elf J Atkinson M Morel L Clare-Salzler MJ McDuffie M 《Journal of immunology (Baltimore, Md. : 1950)》2005,175(7):4561-4565
Unstimulated monocytes of at-risk/type 1 diabetic humans and macrophages of the NOD mouse have markedly elevated autocrine GM-CSF production and persistent STAT5 phosphorylation. We analyzed the relationship between GM-CSF production and persistent STAT5 phosphorylation in NOD macrophages using reciprocal congenic mouse strains containing either diabetes-susceptible NOD (B6.NODC11), or diabetes-resistant C57L (NOD.LC11) loci on chromosome 11. These intervals contain the gene for GM-CSF (Csf2; 53.8 Mb) and those for STAT3, STAT5A, and STAT5B (Stat3, Stat5a, and Stat5b; 100.4-100.6 Mb). High GM-CSF production and persistent STAT5 phosphorylation in unactivated NOD macrophages can be linked to a region (44.9-55.7 Mb) containing the Csf2 gene, but not the Stat3/5a/5b genes. This locus, provisionally called Idd4.3, is upstream of the previously described Idd4.1 and Idd4.2 loci. Idd4.3 encodes an abundance of cytokine genes that use STAT5 in their macrophage activation signaling and contributes approximately 50% of the NOD.LC11 resistance to diabetes. 相似文献
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