bantam miRNA Promotes Systemic Growth by Connecting Insulin Signaling and Ecdysone Production

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Highlights? bantam is required in ecdysone-producing cells to promote body growth ? bantam inhibits ecdysone biosynthesis ? Insulin signaling regulates ecdysone production by repressing bantam activity ? Both the systemic and tissue-autonomous activities of bantam promote organ growth     

Role of the Mad2 Dimerization Interface in the Spindle Assembly Checkpoint Independent of Kinetochores

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Highlights? Mad2 overexpression activates the SAC independently from Mad1 in budding yeast ? Mad2 dimerization surface is required for the SAC independently from Mad1 ? Mad2 dimerization downstream of kinetochores is negligible for the SAC ? Mad2 dimerization surface interacts with Mad3 and is required for MCC stability     

The WW Domain Protein Kibra Acts Upstream of Hippo in Drosophila

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Highlights? The WW domain protein Kibra is a Hippo signalling component ? Kibra restricts organ size via Yorkie and acts upstream of Hippo and Merlin ? Kibra synergizes with Expanded and binds to Merlin     

The Centrosome Regulates the Rab11- Dependent Recycling Endosome Pathway at Appendages of the Mother Centriole

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Highlights? Endosome-proteins localize to centrosomes independent of membranes ? Rab11 and its modulators localize to mother centriole appendages ? Mother centriole appendages regulate membrane recycling through Rab11     

Characterization and In Vivo Pharmacological Rescue of a Wnt2-Gata6 Pathway Required for Cardiac Inflow Tract Development

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Highlights? Wnt2 is required for atrial and inflow tract morphogenesis ? Wnt2 regulates expansion of secondary heart field progenitors ? Defects in Wnt2^?/? mutants can be rescued using Wnt signaling agonists ? Wnt2 cooperates with Gata6 to regulate cardiac inflow tract development     

Stage-Specific Roles for Tet1 and Tet2 in DNA Demethylation in Primordial Germ Cells

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Highlights? PGCs differentiated from ESCs undergo genome-wide DNA demethylation ? Tet1 and Tet2 do not regulate genome-wide DNA demethylation in PGCs ? Tet1 and Tet2 regulate locus-specific demethylation in PGCs     

Latent Enhancers Activated by Stimulation in Differentiated Cells

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Highlights? Latent enhancers are regulatory elements unmarked and unbound in differentiated cells ? Stimulus-dependent TFs co-opt lineage-determining TFs to activate latent enhancers ? Latent enhancers may confer short-term memory of environmental exposure ? Environmental stimulation qualitatively alters the pre-existing enhancer repertoire     

Moderation of Arabidopsis Root Stemness by CLAVATA1 and ARABIDOPSIS CRINKLY4 Receptor Kinase Complexes

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Highlights? CLV1 receptor kinase regulates stemness in Arabidopsis root and shoot meristems ? CLV1 and ACR4 form homo- and heteromeric complexes as shown by a novel FRET assay ? CLV1/ACR4 complexes differ in composition between plasma membrane and plasmodesmata ? CLV1/ACR4 complexes regulate distal root meristem maintenance     

p38 MAPK controls prothrombin expression by regulated RNA 3' end processing

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Highlights? External signals regulate 3′ end mRNA processing through p38 MAPK activation ? The mechanism is controlled by a competitive mRNP formation in the 3′UTR ? The mechanism is activated by acute phase stress and inflammation ? The prototypic thrombin links the mechanism to blood coagulation and tumor spread     

Sustained PU.1 Levels Balance Cell-Cycle Regulators to Prevent Exhaustion of Adult Hematopoietic Stem Cells

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Highlights? PU.1 prevents hematopoietic stem cell (HSC) exhaustion ? PU.1 is a master regulator of cell-cycle genes in HSCs ? PU.1 binding mediates chromosome looping in HSCs ? Positive autoregulation via a ?14 kb enhancer sustains PU.1 levels in HSCs     

Loss of Rb Cooperates with Ras to Drive Oncogenic Growth in Mammalian Cells

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Highlights? Oncogenic Ras drives weak growth through the PI3K canonical growth pathway ? A novel E2F-independent role for the Rb family in cell biogenesis ? Ras and loss of Rb synergize to give robust and sustained cell growth ? PI3K pathway is crucial for sustained growth, acting to maintain nutrient uptake     

SIP1 Mediates Cell-Fate Decisions between Neuroectoderm and Mesendoderm in Human Pluripotent Stem Cells

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Highlights? Smad-interacting protein 1 (SIP1) regulates hESC differentiation ? SIP1 upregulation promotes neuroectodermal differentiation ? SIP1 inhibits mesendodermal and endodermal differentiation ? SMAD2/3 and NANOG/OCT4/SOX2 cooperatively regulate SIP1 expression     

JAGGED Controls Growth Anisotropy and Coordination between Cell Size and Cell Cycle during Plant Organogenesis

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Highlights? JAGGED (JAG) is required for growth of initiating floral organs in Arabidopsis ? JAG decouples cell cycle from cell growth during organ emergence ? JAG promotes fast, anisotropic growth when floral organs emerge from the meristem ? JAG directly represses meristem identity genes     

Trachea-Derived Dpp Controls Adult Midgut Homeostasis in Drosophila

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Highlights? Trachea-derived Dpp/Bmp is required for midgut homeostasis ? Dpp expressed in tracheal cells reach intestinal cells through visceral muscles ? Dpp signaling is activated in enterocytes (ECs) in the Drosophila adult midgut ? Dpp signaling stabilizes ECs to restrict intestinal stem cell proliferation     

A three-state model of telomere control over human proliferative boundaries

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Highlights? Human telomeres are protected from the DDR by a higher-order structure. ? Intermediate-state telomeres are susceptible to a DDR and regulate senescence. ? Uncapped-state telomeres are susceptible to fusions and induce crisis. ? Intermediate-state telomeres regulate the prolonged mitosis checkpoint. ? Telomeres may serve as epigenetic sensors of cellular stress.     

Viral-mediated noisy gene expression reveals biphasic E2f1 response to MYC

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Highlights? Gene expression noise is an efficient means to probe dose responses ? Variability in MYC reveals biphasic E2f1 dose response ? Modeling predicts serum attenuates E2F repression by MYC ? Biphasic expression underlies discrimination of aberrant levels of growth signaling