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1.
The implantation of a bipolar partial hip endoprosthesis is a treatment of choice for displaced medial femoral neck fracture. We present an experimental study which asses and compare biomechanical and clinical status through period before and after hip fracture and implantation of bipolar partial hip endoprosthesis. This study encompassed 75 patients who suffered from an acute medial femoral neck fracture and were treated with the implantation of a bipolar partial hip endoprosthesis. Their biomechanical status (stress distribution on the hip joint weight bearing area) and clinical status (Harris Hip Score) were estimated for the time prior to the injury and assessed at the follow-up examination that was, on average, carried out 40 months after the operation. Despite ageing, the observed Harris Hip Score at the follow-up examination was higher than that estimated prior to the injury (77.9 > 69.6; p = 0.006). Similarly, the hip stress distribution was reduced (2.7 MPa < 2.3 MPa; p = 0.001). While this reduction can be attributed to a loss of weight due to late ageing, the principal improvement came from the operative treatment and corresponding restoration of the biomechanical properties of the hip joint. The implantation of a bipolar partial hip endoprosthesis for patients with displaced medial femoral neck fractures improves the biomechanical and clinical features of the hip, what should have on mind during making decision about treatment.  相似文献   

2.
We retrospectively analyzed 1334 patients who were implanted standard gamma interlocking nails® (SGN) to stabilize trochanteric femoral fractures over the years 1992–1998. Reoperation to remove the nails was performed in 37 patients, in 9 of them purely because of pain. Three out of these 9 patients with removed SGN suffered femoral neck fractures in the early postoperative course after having been mobilized to full weight-bearing capacity. This complication was not observed with other implant systems and, considering the notoriously high complication rate of femoral neck fractures, severely reduces the value of the SGN concept per se. These findings in combination with other known shortcomings of SGNs prompted us to conduct an experimental study on the fracture force of excavated femurs addressing the hypothesis that the specific design of the SGN is responsible for the occurrence of fatigue fractures of the femoral neck. Eighteen matched pairs of fresh human cadaveric proximal femurs, which were treated by insertion and removal of (i) SGNs or (ii) dynamic hip screws® (DHS) or (iii) by excavation in the absence of an implant, were subjected to incremental loading cycles and compared to the untreated contralateral femurs. Overall, the fracture force was found to be significantly lower among the treated than among the untreated bones. However, the fracture force required after removal of the DHS system was still significantly higher than for SGN or excavation alone. In this way, our findings demonstrate that removing relatively big implants such as SGN can cause serious complications such as femoral neck fractures. We therefore recommend to leave this type of device in place even after fracture healing except in cases of deep and chronic infection.  相似文献   

3.
OBJECTIVE--To study the mortality and morbidity associated with proximal femoral fractures with reference to fracture type (intracapsular and extracapsular). DESIGN--Consecutive prospective study with 12 month follow ups. SETTING--Two British trauma receiving centres. PATIENTS--1000 consecutive acute proximal femoral fractures (fractured necks of femur) in 972 patients. RESULTS--Significantly higher mortality at one year was seen in patients with extracapsular fractures (188/490; 38%) than in those with intracapsular fractures (147/510; 29%; p < 0.01). Greater morbidity was experienced during the study period by patients with extracapsular fractures, who were less mobile and less independent at the time of their injury. CONCLUSIONS--The rise in average age of presentation with proximal femoral fracture is associated with a persistently high mortality (33%) and morbidity, greater in patients with an extracapsular fracture. Comparison with other studies, principally from outside Britain, is difficult, but despite advancing standards of care the mortality and morbidity of femoral neck fractures remains high, placing an ever increasing burden on the health service.  相似文献   

4.
A prospective study of fractures of the femoral neck was conducted over 12 months in order to ascertain the relevance of generalised osteoporosis as determined by metacarpal morphometry. A series of some 200 women sustaining a fracture of the femoral neck after minor trauma had bone mass measurements similar to those of a control population of normal women, and 16% were not osteoporotic. A history of previous fractures was documented in one third of the women, but this was unrelated to the presence or severity of osteoporosis, although over half of the fractures had occurred within the previous four years. Trochanteric fractures were seen more commonly in severely osteoporotic women (p less than 0.005), whereas cervical fractures predominated in those who were not osteoporotic. These findings support the hypothesis that postural instability is the major determinant for femoral neck fracture and that generalised osteoporosis, rather than being a prerequisite for fracture, merely determines the type of fracture sustained.  相似文献   

5.
目的:分析股骨颈短缩的发生率、对骨折愈合造成的影响以及造成颈短缩的影响因素。方法:选择在我院行闭合复位空心钉内固定术治疗并成功获得随访信息的老年股骨颈骨折患者106例作为研究对象。于术后1、3、6、12个月对患者进行门诊随访,记录患者的髋关节Harris评分、骨折愈合情况以及颈短缩的发生率,并将患者分为短缩组和无短缩组,对两组患者的骨折愈合率与髋关节Harris评分进行对比,并分析空心钉内固定术后颈短缩发生的危险因素。结果:短缩组43例,未短缩组63例。短缩组中骨折愈合率93.02%;未短缩组中骨折愈合率93.65%,两组骨折愈合率的差异无统计学意义(P>0.05)。短缩组中术后髋关节Harris评分为(74.58±7.85)分;未短缩组中术后髋关节Harris评分为(85.69±11.34)分,短缩组Harris评分低于未短缩组,差异有统计学意义(P<0.05)。颈短缩的发生与年龄、性别、骨折类型、骨密度值及骨折复位质量密切相关(P<0.05),与受伤至手术时间、置入方式、负重时间、住院时间无明显的相关性(P>0.05)。颈短缩的发生与骨密度值和骨折复位质量相关性最大,骨折类型与年龄次之,性别的相关性相对较小。结论:空心钉内固定治疗股骨颈骨折并发颈短缩的发生率较高,颈短缩会影响髋关节的功能,但不影响骨折的愈合。骨密度、骨折复位质量、骨折类型、年龄以及性别是颈短缩的独立影响因素。  相似文献   

6.
摘要 目的:探讨血清微小核糖核酸(miR)-203a、miR-31-5p、miR-19b-1-5p水平与股骨颈骨折患者术后骨折延迟愈合的关系及对术后骨折延迟愈合的预测价值。方法:选择2020年1月~2022年10月在徐州医科大学附属医院行内固定治疗的292例新鲜股骨颈骨折患者为研究对象。于术后4周复查时,检测患者血清miR-203a、miR-31-5p、miR-19b-1-5p水平;并根据其骨折愈合情况分为延迟组(n=36)和愈合组(n=256)。采用多因素Logistic回归分析股骨颈骨折患者术后骨折延迟愈合的影响因素。采用受试者工作特征(ROC)曲线分析血清miR-203a、miR-31-5p、miR-19b-1-5p对股骨颈骨折患者术后骨折延迟愈合的预测价值。结果:术后4个月复查时,骨折延迟愈合发生率为12.33%。两组年龄、吸烟史、合并糖尿病组间比较,差异有统计学意义(P<0.05)。愈合组血清miR-203a、miR-31-5p、miR-19b-1-5p水平均高于延迟组(P<0.05)。多因素Logistic回归分析结果显示,年龄≥60岁、合并糖尿病、血清miR-203a、miR-31-5p、miR-19b-1-5p水平降低是股骨颈骨折患者术后骨折延迟愈合的独立危险因素(P<0.05)。ROC曲线结果显示,三者联合检测的曲线下面积(AUC)(0.95CI)为0.841(0.738~0.936),高于各指标单独应用时的AUC,三者联合检测的灵敏度和特异度亦高于单一指标检测。结论:血清miR-203a、miR-31-5p、miR-19b-1-5p在股骨颈骨折术后骨折延迟愈合患者中呈低表达,是骨折延迟愈合的独立危险因素,三者联合检测对股骨颈骨折患者骨折延迟愈合具有较高的预测价值。  相似文献   

7.
Results of recent imaging studies and theoretical models suggest that the superior femoral neck is a location of local weakness due to an age-related thinning of the cortex, and thus the site of hip fracture initiation. The purpose of this study was to experimentally determine the spatial and temporal characteristics of the macroscopic failure process during a simulated hip fracture that would occur as a result of a sideways fall. Twelve fresh frozen human cadaveric femora were used in this study. The femora were fractured in an apparatus designed to simulate a fall on the greater trochanter. Image sequences of the surface events related to the fractures were captured using two high-speed video cameras at 9111 Hz. The videos were analyzed with respect to time and load to determine the location and sequence of these events occurring in the proximal femur. The mean failure load was 4032 N (SD 370 N). The first surface events were identified in the superior femoral neck in eleven of the twelve specimens. Nine of these specimens fractured in a clear two-step process that initiated with a failure in the superior femoral neck, followed by a failure in the inferior femoral neck. This cadaveric model of hip fracture empirically confirms hypotheses that suggested that hip fractures initiate with a failure in the superior femoral neck where stresses are primarily compressive during a sideways fall impact, followed by a failure in the inferior neck where stresses are primarily tensile. Our results confirm the superolateral neck of the femur as an important region of interest for future hip fracture screening, prevention and treatment research.  相似文献   

8.
目的:探讨全髋关节置换术与人工股骨头置换术治疗老年股骨颈骨折的疗效。方法:选择在我院的82例行手术置换治疗的老年股骨颈骨折患者,随机分为观察组和对照组,每组41例。观察组采用全髋关节置换术,而对照组实施人工股骨头置换术。观察并比较两组患者的手术时间、术中出血量、血压、术后引流及髋关节功能等。结果:观察组手术时间、术中出血量及收缩压均显著高于对照组,差异具有统计学意义(P<0.05);术后引流量及并发症的发生率,两组比较无显著性差异(P>0.05)。观察组患者术后Harris评分为(93.25±4.51),对照组患者Harris评分为(82.76±3.82),观察组显著优于对照组,差异具有统计学意义(P<0.05)。结论:与人工股骨头置换术相比,全髋关节置换术用于治疗老年股骨颈骨折具有创伤小,恢复快的临床效果,患者术后髋关节功能恢复情况良好,值得在临床推广应用。  相似文献   

9.
目的 探讨犬自体髂骨骨膜游离移植治疗股骨颈骨折的效果。方法 选用毕格犬 7只 ,共 14个髋关节 ,制成股骨颈骨折模型 ,骨折经螺钉固定后 ,取髂骨骨膜移植于骨折处。于术后 1个月和 3个月X线拍片并取髋关节标本观察。结果 术后 1个月 :X线见骨折线模糊 ;肉眼观察 :移植的骨膜与股骨颈生长在一起 ;镜下观察 :骨膜内毛细血管大量增生 ,大量类骨质及软骨细胞生成。术后 3个月 :X线见骨折愈合 ;肉眼观察 :骨膜移植处有大量骨组织生长 ,填满了骨折端 ;镜下 :骨膜内血管网非常丰富 ,大量骨细胞生成 ,新生骨小梁深入到股骨颈原有骨小梁中并与之融合。结论 犬自体髂骨骨膜游离移植可以成活和成骨 ,能重建股骨颈血运 ,促进骨折愈合。  相似文献   

10.
Elderly frequently present variable degrees of osteopenia, sarcopenia, and neuromotor control degradation. Severely osteoporotic patients sometime fracture their femoral neck when falling. Is it possible that such fractures might occur without any fall, but rather spontaneously while the patient is performing normal movements such as level walking? The aim of this study was to verify if such spontaneous fractures are biomechanically possible, and in such case, which conditions of osteoporosis, sarcopenia, and neuromotor degradation could produce them. To the purpose, a probabilistic multiscale body-organ model validated against controlled experiments was used to predict the risk of spontaneous fractures in a population of 80-years old women, with normal weight and musculoskeletal anatomy, and variable degree of osteopenia, sarcopenia, and neuromotor control degradation. A multi-body inverse dynamics sub-model, coupled to a probabilistic neuromuscular sub-model, and to a femur finite element sub-model, formed the multiscale model, which was run within a Monte Carlo stochastic scheme, where the various parameters were varied randomly according to well defined distributions. The model predicted that neither extreme osteoporosis, nor extreme neuromotor degradation alone are sufficient to predict spontaneous fractures. However, when the two factors are combined an incidence of 0.4% of spontaneous fractures is predicted for the simulated population, which is consistent with clinical reports. When the model represented only severely osteoporotic patients, the incidence of spontaneous fractures increased to 29%. Thus, is biomechanically possible that spontaneous femoral neck fractures occur during level walking, due to a combination of severe osteoporosis and severe neuromotor degradation.  相似文献   

11.
目的:探究人工髋关节置换术治疗高龄患者股骨粗隆间骨折的临床疗效。方法:选择40例高龄股骨粗隆间骨折患者并将其随机分为两组,观察组给予人工髋关节置换术治疗,对照组经股骨近端髓内钉内固定术治疗。观察比较两组L2-4椎体骨密度、疼痛程度、髋关节功能恢复情况及Harris评分。结果:治疗后,两组L2-4椎体骨密度均显著高于治疗前(P0.05),且观察组显著高于对照组(P0.05);观察组疼痛比例较治疗前明显降低(P0.05),且显著低于对照组(P0.05);观察组髋关节恢复优良率为95.0%,显著高于对照组(70.0%,P0.05);两组Harris评分均显著高于治疗前(P0.05),且观察组显著高于对照组(P0.05)。结论:采用人工髋关节置换术治疗高龄股骨粗隆间骨折的疗效明显优于经股骨近端髓内钉内固定术治疗,其可有效促进髋关节功能恢复,减轻患者疼痛。  相似文献   

12.
目的:研究分析急诊闭合复位和切开复位空心钉治疗股骨颈骨折的疗效。方法:选取2013年6月至2014年6月期间于我院接受治疗的92例急诊股骨颈骨折患者,将所有患者(按随机数字表法)均分为观察组(n=46)和对照组(n=46)。观察组患者采取切开复位空心钉治疗法进行治疗,对照组则采取闭合复位空心钉治疗法进行诊疗。比较两组患者术中术后情况、随访中髋关节功能Harris评分以及相关术后并发症情况。结果:观察组患者所需的手术时间、术中出血量、伤口长度明显多于对照组[(61.43±5.34)min、(30.54±4.27)m L、(6.43±0.56)cm比(46.54±3.26)min、(16.43±2.43)m L、(1.83±0.44)cm](P0.05)。观察组的髋关节功能Harris评分优良率显著高于对照组[82.61%(38/46)比50.00%(23/46)](P0.05)。两组患者的骨折不愈合率比较无显著性差异(P0.05),观察组的股骨头坏死率显著低于对照组[2.17%(1/46)比13.04%(6/46)](P0.05)。结论:应用切开复位空心钉治疗股骨颈骨折患者的方法更佳,其临床治疗效果更好且患者股骨头发生缺血坏死的几率也更低。  相似文献   

13.
Load applicator (platen) geometry used for axial load to failure testing of the femoral neck varies between studies and the biomechanical consequences are unknown. The purpose of this study was to determine if load application with a flat versus a conical platen results in differing fracture mechanics. Femurs were aligned in 25° of adduction and an axial compressive force was applied to the femoral heads at a rate of 6 mm/min until failure. Load application with the conical platen resulted in an average ultimate failure load, stiffness, and energy to failure of 9067 N, 4033 N/mm, and 12.12 J, respectively. Load application with the flat platen resulted in a significant (p<0.05) reduction in ultimate failure load (7620 N) and stiffness (2924 N/mm). Energy to failure (12.30 J) was not significantly different (p=0.893). Different fracture patterns were observed for the two platens and the conical platen produced fractures more similar to clinical observations. Use of a flat platen underestimates the strength and stiffness of the femoral neck and inaccurately predicts the associated fracture pattern. These findings must be considered when interpreting the results of prior biomechanical studies on femoral neck fracture and for the development of future femoral neck fracture models.  相似文献   

14.
In a review of subcapital fractures due to metastases in the femoral neck it was found that in the majority of cases pain in the region of the hip developed a few days prior to fracture. While the majority of subcapital fractures are sustained as the result of a single incident of trauma, in cases with metastases trabecular stress fractures occur in increasing numbers until finally femoral neck fracture occurs. It would seem that once a critical number of trabecular stress fractures has been reached the patient develops pain. Immediate radiologic examination should be performed, and if there is evidence of bone destruction approaching 50% of the cortex, prophylactic hip pinning is strongly indicated.  相似文献   

15.
目的:探究骨密度与老年髋部骨折股骨近端三维有限元模型密度的关系。方法:选取8 例老年髋部骨折,其中4 例股骨颈骨 折,4 例股骨转子间骨折;左侧肢体3 例,右侧肢体5 例。分别测定腰椎骨密度和双侧髋关节CT 资料,运用Mimics软件和abaqus 软件对健侧股骨近端进行重建和计算出该模型的密度。结果:股骨转子间骨折组腰椎骨密度为(-4.05± 0.24) g/cm2,三维有限元模 型密度为[(1.15± 0.02)× 106],均低于股骨颈骨折组的(-3.15± 0.54) g/cm2,[(1.34± 0.06)× 106],两组比较差异均有统计学意义(均 P<0.05)。腰椎的骨密度与三维有限元模型密度成线性正相关(r=0.881,P=0.004)。结论:骨密度与老年髋部骨折股骨近端三维有限 元模型密度成线性正相关的关系,可为进一步用有限元分析法探讨老年髋部骨折部位与骨密度的关系提供理论依据。  相似文献   

16.
Fragility fractures, including neck of femur fractures, result from reductions in the amount, quality and architecture of bone. The aim of this study was to compare the cancellous bone structure, and static indices of bone turnover, in female patients who had sustained fragility fracture at the femoral neck, with age-matched females without fragility fracture. Bone samples were taken from the intertrochanteric region of the proximal femur of female patients undergoing hip arthroplasty surgery for a subcapital fragility fracture of the femoral neck (#NOF) or from age-matched female control individuals at routine autopsy. The histomorphometric data, which were normally distributed, indicated no difference between the mean values for any of the structural parameters in control and fracture samples. In particular, the BV/TV values were not different and did not change significantly with age in these cohorts of individuals aged >65 years. The static indices of bone turnover, eroded surface (ES/BS) and osteoid surface (OS/BS), were positively correlated with age in the >65-year-old control group (p<0.05 and p<0.03, respectively). The median values for these indices were not different between the fracture and control groups. However, both the median and the range of OS/BS values were increased for >65-year-old controls compared with a group of younger females aged <65 years, suggesting an increase in bone formation in older females in the proximal femur after 65 years of age. When the data were further interrogated, a reduction in the percentage osteoid surface to eroded surface quotient (OS/ES) was found for the fracture group compared with the age-matched control group. These data indicate that perturbations in bone formation and/or resorption surface are potentially important in producing bone in the proximal femur with increased propensity to fracture. These data also support the concept that trabecular bone modeling may be a factor influencing bone strength in addition to bone mass.  相似文献   

17.
目的:探讨血府逐瘀汤对股骨颈骨折术后患者转化生长因子β(TGF-β)、血管内皮生长因子(VEGF)、骨形成蛋白-2(BMP-2)表达的影响。方法:选择2014年2月至2014年8月于我院接受治疗的股骨颈骨折患者80例,随机分为实验组和对照组。对照组行常规治疗方案,实验组在常规治疗基础上加用血府逐瘀汤。观察并比较两组患者治疗前后自觉疼痛程度及骨折处骨组织TGF-β、VEGF及BMP-2表达的变化。结果:治疗后,两组患者harris评分均高于治疗前,实验组显著高于对照组(P0.05)。两组患者的骨折处骨组织TGF-β、VEGF、BMP-2水平均高于治疗前,实验组高于对照组,差异均有统计学意义(P0.05)。结论:血府逐瘀汤能有效提高股骨颈骨折患者骨折处骨组织TGF-β、VEGF、BMP-2的表达,促进股骨颈骨折的恢复,值得临床应用和推广。  相似文献   

18.
OBJECTIVE--To investigate the utility of risk factors such as bone mineral density, lifestyle, and postural stability in the prediction of osteoporotic fractures. DESIGN--Longitudinal, epidemiological, and population based survey. SETTING--City of Dubbo, New South Wales. SUBJECTS--All residents of Dubbo aged > or = 60 on 1 January 1989. MAIN OUTCOME MEASURE--Incidence of fracture for individual subjects. RESULTS--The overall incidence of atraumatic fractures in men and women was 1.9% and 3.1% per annum respectively. The predominant sites of fracture were hip (18.9%), distal radius (18.5%), ribs and humerus (11.9% in each case), and ankle and foot (9.1% and 6.6% respectively). Major predictors of fractures in men and women were femoral neck bone mineral density, body sway, and quadriceps strength. Age, years since menopause, height, weight, and lifestyle factors were also correlated with bone mineral density and body sway and hence were indirect risk factors for fracture. Discriminant function analysis correctly identified 96% and 93% (sensitivities 88% and 81%) of men and women, respectively, who subsequently developed atraumatic fractures. Predictions based on this model indicated that a woman with a bone mineral density in the lowest quartile in the hip together with high body sway had a 8.4% probability of fracture per annum. This represented an almost 14-fold increase in risk of fracture compared with a woman in the highest bone mineral density quartile with low postural sway. An individual with all three predictors in the "highest risk" quartile had a 13.1% risk of fracture per annum. CONCLUSIONS--Bone mineral density, body sway, and muscle strength are independent and powerful synergistic predictors of fracture incidence.  相似文献   

19.
《Endocrine practice》2013,19(6):989-994
ObjectiveAtypical femoral fractures and osteoporosis of the jaw have been associated with prolonged bisphosphonate therapy for postmenopausal osteoporosis. American Association of Clinical Endocrinologists guidelines suggest a drug holiday after 4 to 5 years of bisphosphonate treatment for moderate-risk patients and 10 years for high-risk patients, but there are minimal data on safe holiday durations. A recent U.S. Food and Drug Administration perspective suggests a treatment duration of 3 to 5 years. Our aim was to describe a group of patients on drug holiday and identify fracture risk.MethodsA retrospective chart review was conducted of 209 patients who started a bisphosphonate drug holiday between 2005 and 2010. Collected data included bone mineral density (BMD), markers of bone turnover, vitamin D status, and clinical and radiographic reports of fractures.ResultsEleven of 209 patients (5.2%) developed a fracture. Their mean age was 69.36 years (±15.58), and the mean lumbar spine and femoral neck T-scores were −2.225 (±1.779) and −2.137 (±0.950), respectively. All patients had a significant increase in bone-specific alkaline phosphatase at 6 months, which was more pronounced in the fracture group (3.0 ± 0.6083 μg/L vs. 1.16 ± 1.9267 μg/L). Over 4 years, there was no significant change in mean lumbar spine BMD for the entire cohort, but there was a statistically significant decline in the femoral neck BMD at year 2 (−0.0084 ± 0.03 gm/cm2).ConclusionThe current practice of initiating BP holidays needs further evaluation, particularly in the real-world setting. Elderly patients and those with very low BMD warrant close follow-up during a drug holiday. A fracture, early significant rise in bone turnover markers, and/or a decline in BMD should warrant resumption of osteoporosis therapy. (Endocr Pract. 2013;19:989-994)  相似文献   

20.
目的:探讨手术时机的选择对股骨颈骨折患者行关节置换术后髋关节功能的影响,为临床骨科手术提供参考。方法:回顾性 分析117 例在我院接受关节置换术的股骨颈骨折患者的临床资料。根据手术时机不同,将患者分为急诊组和择期组,比较两组手 术效果,评价患者术后髋关节功能。结果:急诊组患者的手术时间、术中出血量及住院时间均优于择期手术的患者,差异有统计学 意义(P<0.01);两组患者术后并发症的发生率无显著差异(P>0.05);术后1 个月,急诊组患者的Harris 评分高于择期组,差异有统 计学意义(P<0.01);术后3 个月,两组Harris评分无统计学差异(P>0.05)。结论:股骨颈骨折患者行急诊手术不但缩短手术时间、 降低术中出血量,而且术后对患者的髋关节功能影响较小,有利于恢复。  相似文献   

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